The importance of G protein-coupled receptor kinase 4 (GRK4) in pathogenesis of salt sensitivity, salt sensitive hypertension and response to antihypertensive treatment

International Journal of Molecular Sciences

Volumn 16, Issue 3, 2015, Pages 5741-5749

  Rayner, Brian ^a   Ramesar, Raj ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Ethnicity; GRK4; Salt sensitivity

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENYLATE CYCLASE; ADRENALIN; ALDOSTERONE; ALPHA ADRENERGIC RECEPTOR; AMLODIPINE; ANGIOTENSIN II; ATENOLOL; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE; DOPAMINE 1 RECEPTOR; DOPAMINE RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 4; LEVODOPA; METOPROLOL; NORADRENALIN; OLIGONUCLEOTIDE; PHENYLALANINE; PROTEIN SERINE KINASE; PROTEIN SERINE THREONINE KINASE; RAMIPRIL; RENIN; SODIUM; TYROSINE; TYROSINE 3 MONOOXYGENASE; ANTIHYPERTENSIVE AGENT; GRK4 PROTEIN, HUMAN;

BIOSYNTHESIS; BLOOD PRESSURE REGULATION; DESENSITIZATION; DISEASE ASSOCIATION; HUMAN; HYPERTENSION; INAPPROPRIATE VASOPRESSIN SECRETION; NATRIURESIS; NEPHROSCLEROSIS; PATHOGENESIS; PLASMA RENIN ACTIVITY; PROTEIN EXPRESSION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM EXCRETION; SODIUM TRANSPORT; VASOCONSTRICTION; ANIMAL; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY;

ANIMALIA; RATTUS;

ANIMALS; ANTIHYPERTENSIVE AGENTS; DISEASE MODELS, ANIMAL; G-PROTEIN-COUPLED RECEPTOR KINASE 4; HUMANS; HYPERTENSION; POLYMORPHISM, SINGLE NUCLEOTIDE; SODIUM;

EID: 84925849228     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms16035741     Document Type: Review

References (24)

1. Weinberger, M.H. Salt sensitivity of blood pressure in humans. Hypertension 1996, 27, 481–490.
2. Luft, F.C.; Grim, C.E.; Higgins, J.T., Jr.; Weinberger, M.H. Differences in response to sodium administration in normotensive white and black subjects.[u1] J. Lab. Clin. Med. 1977, 90, 555–562.
3. Mensah, G.A.; Mokdad, A.H.; Ford, E.S.; Greenlund, K.J.; Croft, J.B. State of disparities in cardiovascular health in the United States. Circulation 2005, 1111, 1233–1241.
4. Redmond, N.; Baer, H.J.; Hicks, L.S. Health behaviors and racial disparity in blood pressure control in the National Health and Nutrition Examination Survey. Hypertension 2011, 57, 383–389.
5. Tu, W.; Eckert, G.J.; Hannon, T.S.; Liu, H.; Pratt, L.M.; Wagner, M.A.; DiMeglio, L.A.; Jung, J.; Pratt, J.H. Racial differences in sensitivity of blood pressure to aldosterone. Hypertension 2014, 63, 1212–1218.
6. Rayner, B.L.; Meyers, J.E.; Opie, L.H.; Trinder, Y.A.; Davidson, J.S. Screening for primary aldosteronism—Normal ranges for aldosterone and renin in three South African groups. S. Afr. Med. J. 2001, 91, 594–599.
7. Bailey, M.A.; Shirley, D.G.; Unwin, R.J. Renal physiology. In Comprehensive Clinical Nephrology, 5th ed.; Johnson, R.J., Feehally, J., Floege, J., Eds.; Elsevier, Sanders: Philadelphia, PA, USA, 2014; Chapter 2, pp. 14–27.
8. Gross, P.; Heduschka, P. Inherited disorders of sodium and water metabolism. In Comprehensive Clinical Nephrology, 5th ed.; Johnson, R.J., Feehally, J., Floege, J., Eds.; Elsevier, Sanders: Philadelphia, PA, USA, 2014; Chapter 49, pp. 579–589.
9. Bochud, M.; Staessen, J.A.; Maillard, M.; Mazeko, M.J.; Kuznetsova, T.; Woodiwiss, A.; Richart, T.; Norton, G.; Thijs, L.; Elston, R. et al. Ethnic differences in proximal and distal tubular sodium reabsorbtion are heritable in black and white populations. J. Hypertens. 2009, 27, 606–612.
10. Aperia, A.C. Intrarenal dopamine: A key signal in the interactive regulation of sodium metabolism. Annu. Rev. Physiol. 2000, 62, 621–647.
11. Jose, P.A.; Eisner, G.M.; Felder, R.A. Dopamine and the kidney: A role in hypertension? Curr. Opin. Nephrol. Hypertens. 2003, 12, 189–194.
12. Jose, P.A.; Eisner, G.M.; Felder, R.A. Role of dopamine receptors in the kidney in the regulation of blood pressure. Curr. Opin. Nephrol. Hypertens. 2002, 11, 87–92.
13. Sanada, H.; Yatabe, J.; Midorikawa, S.; Katoh, T.; Hashimoto, S.; Watanabe, T.; Xu, J.; Luo, Y.; Wang, X.; Zeng, C. et al. Amelioration of genetic hypertension by suppression of renal G protein-coupled receptor kinase type 4 expression. Hypertension 2006, 47, 1131–1139.
14. Felder, R.; Sanada, H.; Xu, J.; Wang, Z.; Watanabe, H.; Asico, L.D.; Wang, W.; Zheng, S.; Yamaguchi, I.; Williams, S.M. et al. G protein-coupled receptor kinase 4 variants in human essential hypertension. Proc. Natl. Acad. Sci. USA 2002, 99, 3872–3877.
15. Chen, K.; Fu, C.; Chen, C.; Liu, L.; Ren, H.; Han, Y.; Yang, J.; He, D.; Zhou, L.; Yang, Z. et al. Role of GRK4 in the Regulation of Arterial AT1 Receptor in Hypertension. Hypertension 2014, 63, 289–296.
16. Zhu, H.; Lu, Y.; Wang, X.; Snieder, H.; Treiber, F.A.; Harshfield, G.A.; Dong, Y. The G protein-coupled receptor kinase 4 gene modulates stress-induced sodium excretion in black normotensive adolescents. Pediatr. Res. 2006, 60, 440–442.
17. Rayner, B.; Musekiwa, A.; Lombard, C.; Ramesar, R. The A142V polymorphism of the G protein-coupled receptor kinase 4 gene predicts natriuretic response to saline challenge in young normotensive lean Black and White South African men. Nephrol. Rev. 2011, 3, e9.
18. Yatabe, Y.; Yatabe, M.S.; Yoneda, M.; Felder, R.A.; Jose, P.A.; Sanada, H. Hypertension-related gene polymorphisms of G-protein-coupled receptor kinase 4 are associated with NT-proBNP concentration in normotensive healthy adults. Int. J. Hypertens. 2012, 2012, doi:10.1155/2012/806810.
19. Sanada, H.; Yatabe, J.; Midorikawa, S.; Hashimoto, S.; Watanabe, T.; Moore, J.H.; Ritchie, M.D.; Williams, S.M.; Pezzullo, J.C.; Sasaki, M. et al. Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin. Chem. 2006, 52, 352–360.
20. Speirs, H.J.L.; Katyk, K.; Kumar, N.N.; Benjafield, A.V.; Wang, W.Y.S.; Morris, B.J. Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension. J. Hypertens. 2004, 22, 931–936.
21. Zhu, H.; Lu, Y.; Wang, X.; Treiber, F.A.; Harshfield, G.A.; Snieder, H.; Dong, Y. The G protein-coupled receptor kinase 4 gene affects blood pressure in young normotensive twins.Am. J. Hypertens. 2006, 19, 61–66.
22. Rayner, B.; Ramesar, R.; Steyn, K.; Levitt, N.; Lombard, C.; Charlton, K. G-protein-coupled receptor kinase 4 (GRK-4) polymorphisms predict blood pressure response to dietary modification in black patients with mild to moderate hypertension. J. Hum. Hypertens. 2011, 26, 334–239.
23. Bhatnagar, V.; O’Connor, D.T.; Brophy, V.H.; Schork, N.J.; Richard, E.; Salem, R.M.; Nievergelt, C.M.; Bakris, G.L.; Middleton, J.P.; Norris, K.C. et al. G-Protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among african americans: Sex-specificity and interactions. Am. J. Hypertens. 2009, 22, 332–338.
24. Vandell, A.G.; Lobmeyer, M.T.; Gawronski, B.E.; Langaee, T.Y.; Gong, Y.; Gums, J.G.; Beitelshees, A.L.; Turner, S.T.; Chapman, A.B.; Cooper-Dehoff, R.M. et al. G protein receptor kinase 4 polymorphisms: β-Blocker Pharmacogenetics and treatment-related outcomes in Hypertension. Hypertension 2012, 60, 957–964.