Lipopolysaccharide induces autophagic cell death through the PERK-dependent branch of the unfolded protein response in human alveolar epithelial A549 cells

Cellular Physiology and Biochemistry

Volumn 36, Issue 6, 2015, Pages 2403-2417

  Li, Shaoying ^a,c   Guo, Liang ^a   Qian, Pin ^a   Zhao, Yunfeng ^b   Liu, Ao ^c   Ji, Fuyun ^a   Chen, Liutong ^a   Wu, Xueling ^a,d   Qian, Guisheng ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b Gongli Hospital Pudong New Area   (China)

^c KUNMING GENERAL HOSPITAL   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Autophagy; Endoplasmic reticulum stress; LPS; PERK; Unfolded protein response

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; LIPOPOLYSACCHARIDE; POLYMYXIN B; PROTEIN KINASE; PROTEIN PERK; RAPAMYCIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ATF4 PROTEIN, HUMAN; ATF6 PROTEIN, HUMAN; DNA BINDING PROTEIN; ERN1 PROTEIN, HUMAN; INITIATION FACTOR 2; PERK KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1R15A PROTEIN, HUMAN; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTORS; RIBONUCLEASE; TRANSCRIPTION FACTOR;

A549 CELL LINE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; UNFOLDED PROTEIN RESPONSE; DRUG EFFECTS; EPITHELIUM CELL; LUNG ALVEOLUS; METABOLISM; PATHOLOGY; TUMOR CELL LINE; ULTRASTRUCTURE;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; EPITHELIAL CELLS; EUKARYOTIC INITIATION FACTOR-2; HUMANS; LIPOPOLYSACCHARIDES; PROTEIN PHOSPHATASE 1; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ALVEOLI; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE;

EID: 84939608732     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000430202     Document Type: Article

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