Autophagy protects against senescence and apoptosis via the ras-mitochondria in high-glucose-induced endothelial cells

Cellular Physiology and Biochemistry

Volumn 33, Issue 4, 2014, Pages 1058-1074

  Chen, Fei ^a   Chen, Bin ^a   Xiao, Fen Qiang ^a   Wu, Yu Tao ^a   Wang, Ri Hong ^a   Sun, Ze Wei ^a   Fu, Guo Sheng ^b   Mou, Yun ^b   Tao, Wu ^a   Hu, Xiao Sheng ^a   Hu, Shen Jiang ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Endothelium; High glucose; Rennin angiotensin; Senescence

Indexed keywords

1 (4 DIMETHYLAMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDRO 1H IMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; BECLIN 1; BENAZEPRIL; BETA GALACTOSIDASE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; GLUCOSE; LC3 PROTEIN; LOSARTAN; PROTEIN; PROTEIN P21; PROTEIN P62; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN II; BIOLOGICAL MARKER; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; CARBONYL 3-CHLOROPHENYLHYDRAZONE; HYDRAZONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL AGING; CELL CYCLE ARREST; CELL PROTECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DNA FRAGMENTATION; ENDOTHELIUM CELL; G2 PHASE CELL CYCLE CHECKPOINT; GLUCOSE BLOOD LEVEL; GLUCOSE INTAKE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL TISSUE; AORTA; DIABETES MELLITUS; ENDOTHELIUM; ENZYME ACTIVATION; ANIMAL; CYTOLOGY; DRUG EFFECTS; METABOLISM; SPRAGUE DAWLEY RAT;

RATTUS;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; APOPTOSIS; AUTOPHAGY; BETA-GALACTOSIDASE; CELL AGING; DNA FRAGMENTATION; ENDOTHELIAL CELLS; GLUCOSE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDRAZONES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ANGIOTENSIN, TYPE 1; RENIN-ANGIOTENSIN SYSTEM;

EID: 84897968510     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000358676     Document Type: Article

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