Clozapine induces autophagic cell death in non-small cell lung cancer cells

Cellular Physiology and Biochemistry

Volumn 35, Issue 3, 2015, Pages 945-956

  Yin, Yu Chun ^a   Lin, Chao Cheng ^b   Chen, Tzu Ting ^c   Chen, Jen Yeu ^d   Tsai, Hui Ju ^e,f   Wang, Chia Yu ^a   Chen, Shiow Yi ^a  

^a NATIONAL TAIWAN OCEAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d TAIWAN ADVENTIST HOSPITAL   (Taiwan)

^e NORTHWESTERN UNIVERSITY   (United States)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Antipsychotic; Autophagy; Cell cycle arrest; Clozapine; Lung cancer

Indexed keywords

AUTOPHAGY PROTEIN 7; BAFILOMYCIN A1; CLOZAPINE; PEPTIDE; PROTEIN; PROTEIN P21; PROTEIN P27; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; MACROLIDE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; CANCER CELL LINE; CANCER GROWTH; CANCER INCIDENCE; CANCER PATIENT; CELL CYCLE; CELL CYCLE ARREST; CELL DEATH; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG TARGETING; HUMAN; HUMAN CELL; NON SMALL CELL LUNG CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHIZOPHRENIA; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINT; DRUG EFFECTS; GENETICS; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; AUTOPHAGY; CARCINOMA, NON-SMALL-CELL LUNG; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CLOZAPINE; HUMANS; MACROLIDES; RNA, SMALL INTERFERING; SCHIZOPHRENIA;

EID: 84923088110     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000369751     Document Type: Article

References (45)

1. Winterer G: Why do patients with schizophrenia smoke? Curr Opin Psychiatry 2010;23:112-119.
2. Hecht SS: Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer 2003;3:733-744.
3. Siegel R, Ward E, Brawley O, Jemal A: Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011;61:212-236.
4. Hodgson R, Wildgust HJ, Bushe CJ: Cancer and schizophrenia: Is there a paradox? J Psychopharmacol 2010;24:51-60.
5. Barak Y, Achiron A, Mandel M, Mirecki I, Aizenberg D: Reduced cancer incidence among patients with schizophrenia. Cancer 2005;104:2817-2821.
6. Catts VS, Catts SV, O'Toole BI, Frost AD: Cancer incidence in patients with schizophrenia and their first-degree relatives-a meta-analysis. Acta Psychiatr Scand 2008;117:323-336.
7. Cohen M, Dembling B, Schorling J: The association between schizophrenia and cancer: A population-based mortality study. Schizophr Res 2002;57:139-146.
8. Preti A, Wilson DR: Schizophrenia, cancer and obstetric complications in an evolutionary perspective-an empirically based hypothesis. Psychiatry Investig 2011;8:77-88.
9. Chou FH, Tsai KY, Su CY, Lee CC: The incidence and relative risk factors for developing cancer among patients with schizophrenia: A nine-year follow-up study. Schizophr Res 2011;129:97-103.
10. Bushe CJ, Hodgson R: Schizophrenia and cancer: In 2010 do we understand the connection? Can J Psychiatry 2010;55:761-767.
11. Gil-Ad I, Shtaif B, Levkovitz Y, Dayag M, Zeldich E, Weizman A: Characterization of phenothiazine-induced apoptosis in neuroblastoma and glioma cell lines: Clinical relevance and possible application for brain-derived tumors. J Mol Neurosci 2004;22:189-198.
12. Gil-Ad I, Shtaif B, Levkovitz Y, Nordenberg J, Taler M, Korov I, Weizman A: Phenothiazines induce apoptosis in a b16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth. Oncol Rep 2006;15:107-112.
13. Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH: Chlorpromazine activates p21waf1/cip1 gene transcription via early growth response-1 (egr-1) in c6 glioma cells. Exp Mol Med 2010;42:395-405.
14. Wiklund ED, Catts VS, Catts SV, Ng TF, Whitaker NJ, Brown AJ, Lutze-Mann LH: Cytotoxic effects of antipsychotic drugs implicate cholesterol homeostasis as a novel chemotherapeutic target. Int J Cancer 2010;126:28-40.
15. Zhelev Z, Ohba H, Bakalova R, Hadjimitova V, Ishikawa M, Shinohara Y, Baba Y: Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia. Cancer Chemother Pharmacol 2004;53:267-275.
16. Rubinsztein DC, Marino G, Kroemer G: Autophagy and aging. Cell 2011;146:682-695.
17. Shu CW, Liu PF, Huang CM: High throughput screening for drug discovery of autophagy modulators. Combinatorial chemistry & high throughput screening 2012;15:721-729.
18. Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, Massey DC, Menzies FM, Moreau K, Narayanan U, Renna M, Siddiqi FH, Underwood BR, Winslow AR, Rubinsztein DC: Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 2010;90:1383-1435.
19. Bursch W, Ellinger A, Kienzl H, Torok L, Pandey S, Sikorska M, Walker R, Hermann RS: Active cell death induced by the anti-estrogens tamoxifen and ici 164 384 in human mammary carcinoma cells (mcf-7) in culture: The role of autophagy. Carcinogenesis 1996;17:1595-1607.
20. Ciapparelli A, Dell'Osso L, Bandettini di Poggio A, Carmassi C, Cecconi D, Fenzi M, Chiavacci MC, Bottai M, Ramacciotti CE, Cassano GB: Clozapine in treatment-resistant patients with schizophrenia, schizoaffective disorder, or psychotic bipolar disorder: A naturalistic 48-month follow-up study. J Clin Psychiatry 2003;64:451-458.
21. Veys PA, Wilkes S, Shah S, Noyelle R, Hoffbrand AV: Clinical experience of clozapine-induced neutropenia in the uk. Laboratory investigation using liquid culture systems and immunofluorocytometry. Drug Saf 1992;7:26-32.
22. Martinel Lamas DJ, Croci M, Carabajal E, Crescenti EJ, Sambuco L, Massari NA, Bergoc RM, Rivera ES, Medina VA: Therapeutic potential of histamine h(4) receptor agonists in triple-negative human breast cancer experimental model. Br J Pharmacol 2013;170:188-199.
23. Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH: Annexin v for flow cytometric detection of phosphatidylserine expression on b cells undergoing apoptosis. Blood 1994;84:1415-1420.
24. Moller HJ: Novel antipsychotics in the long-term treatment of schizophrenia. World J Biol Psychiatry 2004;5:9-19.
25. Loeffler S, Fehsel K, Henning U, Fischer J, Agelink M, Kolb-Bachofen V, Klimke A: Increased apoptosis of neutrophils in a case of clozapine-induced agranulocytosis-a case report. Pharmacopsychiatry 2003;36:37-41.
26. Williams DP, Pirmohamed M, Naisbitt DJ, Uetrecht JP, Park BK: Induction of metabolism-dependent and-independent neutrophil apoptosis by clozapine. Mol Pharmacol 2000;58:207-216.
27. Lyons AB: Analysing cell division in vivo and in vitro using flow cytometric measurement of cfse dye dilution. J Immunol Methods 2000;243:147-154.
28. Kimura S, Noda T, Yoshimori T: Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged lc3. Autophagy 2007;3:452-460.
29. Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y: Bafilomycin a1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, h-4-ii-e cells. Cell Struct Funct 1998;23:33-42.
30. Jahreiss L, Menzies FM, Rubinsztein DC: The itinerary of autophagosomes: From peripheral formation to kiss-and-run fusion with lysosomes. Traffic 2008;9:574-587.
31. Nordenberg J, Perlmutter I, Lavie G, Beery E, Uziel O, Morgenstern C, Fenig E, Weizman A: Anti-proliferative activity of haloperidol in b16 mouse and human sk-mel-28 melanoma cell lines. Int J Oncol 2005;27:1097-1103.
32. Shin JH, Park SJ, Kim ES, Jo YK, Hong J, Cho DH: Sertindole, a potent antagonist at dopamine d(2) receptors, induces autophagy by increasing reactive oxygen species in sh-sy5y neuroblastoma cells. Biol Pharm Bull 2012;35:1069-1075.
33. Park J, Chung S, An H, Kim J, Seo J, Kim DH, Yoon SY: Haloperidol and clozapine block formation of autophagolysosomes in rat primary neurons. Neuroscience 2012;209:64-73.
34. Mizushima N, Levine B: Autophagy in mammalian development and differentiation. Nature cell biology 2010;12:823-830.
35. Mitra S, Tsvetkov AS, Finkbeiner S: Protein turnover and inclusion body formation. Autophagy 2009;5:1037-1038.
36. Yang ZJ, Chee CE, Huang S, Sinicrope FA: The role of autophagy in cancer: Therapeutic implications. Mol Cancer Ther 2011;10:1533-1541.
37. Brech A, Ahlquist T, Lothe RA, Stenmark H: Autophagy in tumour suppression and promotion. Mol Oncol 2009;3:366-375.
38. Fleming A, Noda T, Yoshimori T, Rubinsztein DC: Chemical modulators of autophagy as biological probes and potential therapeutics. Nat Chem Biol 2011;7:9-17.
39. Shen HM, Codogno P: Autophagic cell death: Loch ness monster or endangered species? Autophagy 2011;7:457-465.
40. Ge JN, Huang D, Xiao T, Wang Z, Li XL, Xiao H, Tao DD, Gong JP: [effect of starvation-induced autophagy on cell cycle of tumor cells]. Ai Zheng 2008;27:788-794.
41. Tasdemir E, Maiuri MC, Tajeddine N, Vitale I, Criollo A, Vicencio JM, Hickman JA, Geneste O, Kroemer G: Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy. Cell Cycle 2007;6:2263-2267.
42. Contreras-Shannon V, Heart DL, Paredes RM, Navaira E, Catano G, Maffi SK, Walss-Bass C: Clozapine-induced mitochondria alterations and inflammation in brain and insulin-responsive cells. PloS one 2013;8:e59012.
43. Wang JS, Zhu HJ, Markowitz JS, Donovan JL, Yuan HJ, Devane CL: Antipsychotic drugs inhibit the function of breast cancer resistance protein. Basic Clin Pharmacol Toxicol 2008;103:336-341.
44. Ming DS, Heathcote J: Therapeutic drug monitoring of clozapine and norclozapine in human serum using ultra-performance liquid chromatography-tandem mass spectrometry. J Anal Toxicol 2009;33:198-203.
45. Vander Zwaag C, McGee M, McEvoy JP, Freudenreich O, Wilson WH, Cooper TB: Response of patients with treatment-refractory schizophrenia to clozapine within three serum level ranges. Am J Psychiatry 1996;153:1579-1584.