RNAi-mediated replacement of morphine with the nonnarcotic alkaloid reticuline in opium poppy

Nature Biotechnology

Volumn 22, Issue 12, 2004, Pages 1559-1566

  Allen, Robert S ^a   Millgate, Anthony G ^a   Chitty, Julie A ^a   Thisleton, Jennifer ^a   Miller, James A C ^b   Fist, Anthony J ^b   Gerlach, Wayne L ^c   Larkin, Philip J ^a  

^a CSIRO   (Australia)

^b Tasmanian Alkaloids Pty Ltd   (Australia)

^c JOHNSON AND JOHNSON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME KINETICS; GENES; METABOLISM;

FEEDBACK MECHANISM; METABOLIC ENGINEERING; OPIUM POPPY;

RNA;

BENZYLISOQUINOLINE DERIVATIVE; CODEINE; CODEINONE REDUCTASE; MORPHINE; OPIATE; ORIPAVINE; OXIDOREDUCTASE; RETICULINE; RNA; THEBAINE; UNCLASSIFIED DRUG;

ARTICLE; CHIMERA; CONTROLLED STUDY; COR GENE; DEGRADATION KINETICS; DRUG ABUSE; DRUG DESIGN; ENZYME ACTIVITY; FEEDBACK SYSTEM; GENE; GENE CONSTRUCT; GENE SILENCING; METHYLATION; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; PAPAVER SOMNIFERUM; PRIORITY JOURNAL; PRODUCT RECOVERY; RNA ANALYSIS; RNA INTERFERENCE; TRANSCRIPTION REGULATION; TRANSGENIC PLANT;

ALCOHOL OXIDOREDUCTASES; ALKALOIDS; BENZYLISOQUINOLINES; CELLS, CULTURED; GENETIC ENGINEERING; MORPHINE; PAPAVER; PLANTS, GENETICALLY MODIFIED; RNA INTERFERENCE;

PAPAVER; PAPAVER SOMNIFERUM;

EID: 11144352099     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1033     Document Type: Article

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