Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 23, 2006, Pages 8668-8673

  Pillai, Bindu ^a   Cherney, Maia M ^a   Diaper, Christopher M ^a   Sutherland, Andrew ^b   Blanchard, John S ^c   Vederas, John C ^a   James, Michael M G ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Racemase; Stereochemical mechanism

Indexed keywords

ALPHA AMINO ACID; AZIRIDINE DERIVATIVE; AZIRIDINODIAMINOPIMELATE; CYSTEINE; DEXTRO AMINO ACID; DIAMINOPIMELATE EPIMERASE; DIAMINOPIMELIC ACID; DISULFIDE; EPIMERASE; HYDROGEN; PYRIDOXAL 5 PHOSPHATE; RACEMASE; THIOL; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BACTERIAL CELL WALL; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HAEMOPHILUS INFLUENZAE; ISOMER; NONHUMAN; PKA; PRIORITY JOURNAL; PROTON TRANSPORT; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

AMINO ACID ISOMERASES; AMINO ACIDS; ANTI-BACTERIAL AGENTS; AZIRIDINES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HAEMOPHILUS INFLUENZAE; HYDROGEN BONDING; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIDOXAL PHOSPHATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); HAEMOPHILUS INFLUENZAE; TRYPANOSOMA CRUZI;

EID: 33745029007     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0602537103     Document Type: Article

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