Dioxygenases catalyzeo-demethylation and O,O-demethylenation with widespread roles in benzylisoquinoline alkaloid metabolism in opium poppy

Journal of Biological Chemistry

Volumn 288, Issue 40, 2013, Pages 28997-29012

  Farrow, Scott C ^a   Facchini, Peter J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLISOQUINOLINE ALKALOIDS; DEALKYLATION; DIOXYGENASES; MORPHINE BIOSYNTHESIS; OPIUM POPPY; PHYSIOLOGICAL FUNCTIONS; PLANT ALKALOIDS; VIRUS-INDUCED GENE SILENCING;

ALKALOIDS; BIOCHEMISTRY; BIOSYNTHESIS; CHEMICAL REACTIONS; ENZYMES; METABOLISM; NITROGEN COMPOUNDS; PHYSIOLOGY; VIRUSES;

METABOLITES;

2 OXOGLUTARIC ACID; BENZO[C]PHENANTHRIDINE DERIVATIVE; BENZYLISOQUINOLINE ALKALOID; BENZYLISOQUINOLINE DERIVATIVE; CODEINE DEMETHYLASE; CYTOCHROME P450; DIOXYGENASE; ENZYME; FUNCTIONAL GROUP; HYDROXYL GROUP; IRON; METHYLENEDIOXY; MORPHINE; OPIATE; PROTOPINE; PROTOPINE ALKALOID; PROTOPINE O DEALKYLASE; RHOEADINE DERIVATIVE; SANGUINARINE; THEBAINE 6 O DEMETHYLASE; UNCLASSIFIED DRUG; ALLOCRYPTOPINE; BERBERINE DERIVATIVE; FORMALDEHYDE;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DEMETHYLATION; DEMETHYLENATION; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE SILENCING; MAMMAL; NONHUMAN; NUCLEOTIDE SEQUENCE; PLANT METABOLISM; PRIORITY JOURNAL; PROTEIN FUNCTION; BIOCATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MASS SPECTROMETRY (MS); METABOLIC REGULATION; METABOLISM; METHYLATION; PAPAVER; PHYLOGENY; PLANT BIOCHEMISTRY; PLANT PHYSIOLOGY; SECONDARY METABOLISM; VIRUS;

DIOXYGENASE; GENE SILENCING; MASS SPECTROMETRY (MS); METABOLIC REGULATION; PLANT BIOCHEMISTRY; PLANT PHYSIOLOGY; SECONDARY METABOLISM;

BENZYLISOQUINOLINES; BERBERINE ALKALOIDS; BIOCATALYSIS; CHROMATOGRAPHY, LIQUID; DIOXYGENASES; FORMALDEHYDE; GENE SILENCING; KINETICS; MASS SPECTROMETRY; METHYLATION; OPIUM; PAPAVER; PHYLOGENY; SUBSTRATE SPECIFICITY; VIRUSES;

EID: 84885147582     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.488585     Document Type: Article

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