The effect of drug and EUDRAGIT® S 100 miscibility in solid dispersions on the drug and polymer dissolution rate

International Journal of Pharmaceutics

Volumn 494, Issue 1, 2015, Pages 9-16

  Higashi, Kenjirou ^a   Hayashi, Hiroki ^a   Yamamoto, Keiji ^a   Moribe, Kunikazu ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Amorphous solid dispersion; Dissolution rate; Evaporative light scattering detector; Miscibility; Powder X ray diffraction; Solid state NMR

Indexed keywords

EUDRAGIT; GLIBENCLAMIDE; PHENYTOIN; WATER; EXCIPIENT; METHYLMETHACRYLATE-METHACRYLIC ACID COPOLYMER; POLYMER; POLYMETHACRYLIC ACID DERIVATIVE;

ANALYTIC METHOD; ARTICLE; CLINICAL EVALUATION; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; DISSOLUTION; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MISCIBILITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RELAXATION TIME; SOLID DISPERSION; SOLID STATE; SPRAY DRYING; X RAY DIFFRACTION; CHEMISTRY; DESICCATION; DRUG FORMULATION; DRUG STABILITY; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DESICCATION; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; GLYBURIDE; PHENYTOIN; POLYMERS; POLYMETHACRYLIC ACIDS; SOLUBILITY; X-RAY DIFFRACTION;

EID: 84939559450     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.08.007     Document Type: Article

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