메뉴 건너뛰기




Volumn 13, Issue 2, 2015, Pages 129-137

Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders

Author keywords

Anxiety disorders; Clinicaltrials; Depression; Omega 3 (N 3) polyunsaturated fatty acids (PUFA); Psychotic disorders

Indexed keywords

ALPHA INTERFERON; OMEGA 3 FATTY ACID;

EID: 84939504822     PISSN: 17381088     EISSN: 20934327     Source Type: Journal    
DOI: 10.9758/cpn.2015.13.2.129     Document Type: Review
Times cited : (88)

References (100)
  • 2
    • 34548430156 scopus 로고    scopus 로고
    • Most people with mental illness are not treated
    • Thornicroft G. Most people with mental illness are not treated. Lancet 2007;370:807-808.
    • (2007) Lancet , vol.370 , pp. 807-808
    • Thornicroft, G.1
  • 3
    • 84886307623 scopus 로고    scopus 로고
    • Do we need to consider ethno-cultural variation in the use of atypical antipsychotics for Asian patients with major depressive disorder
    • Han C, Pae CU. Do we need to consider ethno-cultural variation in the use of atypical antipsychotics for Asian patients with major depressive disorder? CNS Drugs 2013;27 Suppl 1:S47-S51.
    • (2013) CNS Drugs , vol.27 , pp. S47-S51
    • Han, C.1    Pae, C.U.2
  • 4
    • 84878258617 scopus 로고    scopus 로고
    • Urbanisation, urbanicity, and health: A systematic review of the reliability and validity of urbanicity scales
    • Cyril S, Oldroyd JC, Renzaho A. Urbanisation, urbanicity, and health: a systematic review of the reliability and validity of urbanicity scales. BMC Public Health 2013;13:513.
    • (2013) BMC Public Health , vol.13 , pp. 513
    • Cyril, S.1    Oldroyd, J.C.2    Renzaho, A.3
  • 5
    • 45749151055 scopus 로고    scopus 로고
    • Brain foods: The effects of nutrients on brain function
    • Gómez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci 2008;9:568-578.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 568-578
    • Gómez-Pinilla, F.1
  • 6
    • 84887641056 scopus 로고    scopus 로고
    • Omega-3 polyunsaturated fatty acids for major depressive disorder
    • Su KP, Wang SM, Pae CU. Omega-3 polyunsaturated fatty acids for major depressive disorder. Expert Opin Investig Drugs 2013;22:1519-1534.
    • (2013) Expert Opin Investig Drugs , vol.22 , pp. 1519-1534
    • Su, K.P.1    Wang, S.M.2    Pae, C.U.3
  • 7
    • 84905224875 scopus 로고    scopus 로고
    • Food for thought: Dietary changes in essential fatty acid ratios and the increase in autism spectrum disorders
    • van Elst K, Bruining H, Birtoli B, Terreaux C, Buitelaar JK, Kas MJ. Food for thought: dietary changes in essential fatty acid ratios and the increase in autism spectrum disorders. Neurosci Biobehav Rev 2014;45:369-378.
    • (2014) Neurosci Biobehav Rev , vol.45 , pp. 369-378
    • Van Elst, K.1    Bruining, H.2    Birtoli, B.3    Terreaux, C.4    Buitelaar, J.K.5    Kas, M.J.6
  • 8
    • 84882301131 scopus 로고    scopus 로고
    • Randomized placebo-controlled trials of omega-3 polyunsaturated fatty acids in psychiatric disorders: A review of the current literature
    • Politi P, Rocchetti M, Emanuele E, Rondanelli M, Barale F. Randomized placebo-controlled trials of omega-3 polyunsaturated fatty acids in psychiatric disorders: a review of the current literature. Curr Drug Discov Technol 2013;10: 245-253.
    • (2013) Curr Drug Discov Technol , vol.10 , pp. 245-253
    • Politi, P.1    Rocchetti, M.2    Emanuele, E.3    Rondanelli, M.4    Barale, F.5
  • 10
    • 84882361203 scopus 로고    scopus 로고
    • Long-chain omega-3 fatty acid deficiency in mood disorders: Rationale for treatment and prevention
    • McNamara RK. Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention. Curr Drug Discov Technol 2013;10:233-244.
    • (2013) Curr Drug Discov Technol , vol.10 , pp. 233-244
    • McNamara, R.K.1
  • 12
    • 84866513402 scopus 로고    scopus 로고
    • A meta-analytic review of polyunsaturated fatty acid compositions in dementia
    • Lin PY, Chiu CC, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in dementia. J Clin Psychiatry 2012;73:1245-1254.
    • (2012) J Clin Psychiatry , vol.73 , pp. 1245-1254
    • Lin, P.Y.1    Chiu, C.C.2    Huang, S.Y.3    Su, K.P.4
  • 13
    • 76849103507 scopus 로고    scopus 로고
    • Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels
    • Su KP, Huang SY, Peng CY, Lai HC, Huang CL, Chen YC, et al. Phospholipase A2 and cyclooxygenase 2 genes influence the risk of interferon-alpha-induced depression by regulating polyunsaturated fatty acids levels. Biol Psychiatry 2010;67:550-557.
    • (2010) Biol Psychiatry , vol.67 , pp. 550-557
    • Su, K.P.1    Huang, S.Y.2    Peng, C.Y.3    Lai, H.C.4    Huang, C.L.5    Chen, Y.C.6
  • 14
    • 77954204762 scopus 로고    scopus 로고
    • A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression
    • Lin PY, Huang SY, Su KP. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol Psychiatry 2010;68:140-147.
    • (2010) Biol Psychiatry , vol.68 , pp. 140-147
    • Lin, P.Y.1    Huang, S.Y.2    Su, K.P.3
  • 15
    • 44849092681 scopus 로고    scopus 로고
    • Omega-3 fatty acids for major depressive disorder during pregnancy: Results from a randomized, doubleblind, placebo-controlled trial
    • Su KP, Huang SY, Chiu TH, Huang KC, Huang CL, Chang HC, et al. Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, doubleblind, placebo-controlled trial. J Clin Psychiatry 2008;69: 644-651.
    • (2008) J Clin Psychiatry , vol.69 , pp. 644-651
    • Su, K.P.1    Huang, S.Y.2    Chiu, T.H.3    Huang, K.C.4    Huang, C.L.5    Chang, H.C.6
  • 16
    • 46049113360 scopus 로고    scopus 로고
    • Mind-body interface: The role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression
    • Su KP. Mind-body interface: the role of n-3 fatty acids in psychoneuroimmunology, somatic presentation, and medical illness comorbidity of depression. Asia Pac J Clin Nutr 2008;17 Suppl 1:151-157.
    • (2008) Asia Pac J Clin Nutr , vol.17 , pp. 151-157
    • Su, K.P.1
  • 17
    • 34548315737 scopus 로고    scopus 로고
    • A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids
    • Lin PY, Su KP. A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids. J Clin Psychiatry 2007;68:1056-1061.
    • (2007) J Clin Psychiatry , vol.68 , pp. 1056-1061
    • Lin, P.Y.1    Su, K.P.2
  • 18
    • 59149104081 scopus 로고    scopus 로고
    • Biological mechanism of antidepressant effect of omega-3 fatty acids: How does fish oil act as a 'mind-body interface
    • Su KP. Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a 'mind-body interface'? Neurosignals 2009;17:144-152.
    • (2009) Neurosignals , vol.17 , pp. 144-152
    • Su, K.P.1
  • 20
    • 84862764317 scopus 로고    scopus 로고
    • Inflammation in psychopathology of depression: Clinical, biological, and therapeutic implications
    • Su KP. Inflammation in psychopathology of depression: clinical, biological, and therapeutic implications. Bio-Medicine 2012;2:68-74.
    • (2012) Bio-Medicine , vol.2 , pp. 68-74
    • Su, K.P.1
  • 21
    • 78651292670 scopus 로고    scopus 로고
    • Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: Implications of antidepressant effects for -3 fatty acids
    • Lu DY, Tsao YY, Leung YM, Su KP. Docosahexaenoic acid suppresses neuroinflammatory responses and induces heme oxygenase-1 expression in BV-2 microglia: implications of antidepressant effects for -3 fatty acids. Neuropsychopharmacology 2010;35:2238-2248.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 2238-2248
    • Lu, D.Y.1    Tsao, Y.Y.2    Leung, Y.M.3    Su, K.P.4
  • 22
    • 84897524503 scopus 로고    scopus 로고
    • Prevention: Before the break
    • Solis M. Prevention: Before the break. Nature 2014;508: S12-S13.
    • (2014) Nature , vol.508 , pp. S12-S13
    • Solis, M.1
  • 23
    • 0037137299 scopus 로고    scopus 로고
    • American Heart Association, nutrition committee,fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    • Kris-Etherton PM, Harris WS, Appel LJ; American Heart Association, Nutrition Committee. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002;106:2747-2757.
    • (2002) Circulation , vol.106 , pp. 2747-2757
    • Kris-Etherton, P.M.1    Harris, W.S.2    Appel, L.J.3
  • 24
    • 79954592668 scopus 로고    scopus 로고
    • (Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: From antioxidants to kinase inhibitors
    • Maes M, Leonard B, Fernandez A, Kubera M, Nowak G, Veerhuis R, et al. (Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: from antioxidants to kinase inhibitors. Prog Neuropsychopharmacol Biol Psychiatry 2011;35:659-663.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 659-663
    • Maes, M.1    Leonard, B.2    Fernandez, A.3    Kubera, M.4    Nowak, G.5    Veerhuis, R.6
  • 25
    • 0032542958 scopus 로고    scopus 로고
    • Fish consumption and major depression
    • Hibbeln JR. Fish consumption and major depression. Lancet 1998;351:1213.
    • (1998) Lancet , vol.351 , pp. 1213
    • Hibbeln, J.R.1
  • 26
    • 33746813253 scopus 로고    scopus 로고
    • Healthy intakes of n-3 and n-6 fatty acids: Estimations considering worldwide diversity
    • Hibbeln JR, Nieminen LR, Blasbalg TL, Riggs JA, Lands WE. Healthy intakes of n-3 and n-6 fatty acids: estimations considering worldwide diversity. Am J Clin Nutr 2006;83(6 Suppl):1483S-1493S.
    • (2006) Am J Clin Nutr , vol.83 , Issue.6 , pp. 1483S-1493S
    • Hibbeln, J.R.1    Nieminen, L.R.2    Blasbalg, T.L.3    Riggs, J.A.4    Lands, W.E.5
  • 27
    • 0037668364 scopus 로고    scopus 로고
    • Cross-national comparisons of seafood consumption and rates of bipolar disorders
    • Noaghiul S, Hibbeln JR. Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am J Psychiatry 2003;160:2222-2227.
    • (2003) Am J Psychiatry , vol.160 , pp. 2222-2227
    • Noaghiul, S.1    Hibbeln, J.R.2
  • 28
    • 34250163939 scopus 로고    scopus 로고
    • Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder
    • McNamara RK, Hahn CG, Jandacek R, Rider T, Tso P, Stanford KE, et al. Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder. Biol Psychiatry 2007;62:17-24.
    • (2007) Biol Psychiatry , vol.62 , pp. 17-24
    • McNamara, R.K.1    Hahn, C.G.2    Jandacek, R.3    Rider, T.4    Tso, P.5    Stanford, K.E.6
  • 29
    • 84885860989 scopus 로고    scopus 로고
    • Abnormalities in the fatty acid composition of the postmortem entorhinal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder
    • Hamazaki K, Hamazaki T, Inadera H. Abnormalities in the fatty acid composition of the postmortem entorhinal cortex of patients with schizophrenia, bipolar disorder, and major depressive disorder. Psychiatry Res 2013;210:346-350.
    • (2013) Psychiatry Res , vol.210 , pp. 346-350
    • Hamazaki, K.1    Hamazaki, T.2    Inadera, H.3
  • 30
    • 84863483992 scopus 로고    scopus 로고
    • Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, and major depressive disorder
    • Hamazaki K, Hamazaki T, Inadera H. Fatty acid composition in the postmortem amygdala of patients with schizophrenia, bipolar disorder, and major depressive disorder. J Psychiatr Res 2012;46:1024-1028.
    • (2012) J Psychiatr Res , vol.46 , pp. 1024-1028
    • Hamazaki, K.1    Hamazaki, T.2    Inadera, H.3
  • 31
    • 0141989942 scopus 로고    scopus 로고
    • Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: Further evidence that lowered n-PUFAs are related to major depression
    • De Vriese SR, Christophe AB, Maes M. Lowered serum n-3 polyunsaturated fatty acid (PUFA) levels predict the occurrence of postpartum depression: further evidence that lowered n-PUFAs are related to major depression. Life Sci 2003;73:3181-3187.
    • (2003) Life Sci , vol.73 , pp. 3181-3187
    • De Vriese, S.R.1    Christophe, A.B.2    Maes, M.3
  • 32
    • 31344470083 scopus 로고    scopus 로고
    • Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder
    • Green P, Hermesh H, Monselise A, Marom S, Presburger G, Weizman A. Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder. Eur Neuropsychopharmacol 2006;16:107-113.
    • (2006) Eur Neuropsychopharmacol , vol.16 , pp. 107-113
    • Green, P.1    Hermesh, H.2    Monselise, A.3    Marom, S.4    Presburger, G.5    Weizman, A.6
  • 33
    • 0037830953 scopus 로고    scopus 로고
    • Plasma fatty acid composition and depression are associated in the elderly: The Rotterdam study
    • Tiemeier H, van Tuijl HR, Hofman A, Kiliaan AJ, Breteler MM. Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study. Am J Clin Nutr 2003;78:40-46.
    • (2003) Am J Clin Nutr , vol.78 , pp. 40-46
    • Tiemeier, H.1    Van Tuijl, H.R.2    Hofman, A.3    Kiliaan, A.J.4    Breteler, M.M.5
  • 34
    • 1942488899 scopus 로고    scopus 로고
    • Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes
    • Frasure-Smith N, Lespérance F, Julien P. Major depression is associated with lower omega-3 fatty acid levels in patients with recent acute coronary syndromes. Biol Psychiatry 2004;55:891-896.
    • (2004) Biol Psychiatry , vol.55 , pp. 891-896
    • Frasure-Smith, N.1    Lespérance, F.2    Julien, P.3
  • 36
    • 77956267481 scopus 로고    scopus 로고
    • Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder
    • McNamara RK, Jandacek R, Rider T, Tso P, Dwivedi Y, Pandey GN. Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder. J Affect Disord 2010;126:303-311.
    • (2010) J Affect Disord , vol.126 , pp. 303-311
    • McNamara, R.K.1    Jandacek, R.2    Rider, T.3    Tso, P.4    Dwivedi, Y.5    Pandey, G.N.6
  • 37
    • 0344628598 scopus 로고    scopus 로고
    • Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients
    • Ranjekar PK, Hinge A, Hegde MV, Ghate M, Kale A, Sitasawad S, et al. Decreased antioxidant enzymes and membrane essential polyunsaturated fatty acids in schizophrenic and bipolar mood disorder patients. Psychiatry Res 2003;121:109-122.
    • (2003) Psychiatry Res , vol.121 , pp. 109-122
    • Ranjekar, P.K.1    Hinge, A.2    Hegde, M.V.3    Ghate, M.4    Kale, A.5    Sitasawad, S.6
  • 38
    • 35748982627 scopus 로고    scopus 로고
    • Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania
    • Sublette ME, Bosetti F, DeMar JC, Ma K, Bell JM, Fagin-Jones S, et al. Plasma free polyunsaturated fatty acid levels are associated with symptom severity in acute mania. Bipolar Disord 2007;9:759-765.
    • (2007) Bipolar Disord , vol.9 , pp. 759-765
    • Sublette, M.E.1    Bosetti, F.2    DeMar, J.C.3    Ma, K.4    Bell, J.M.5    Fagin-Jones, S.6
  • 39
    • 55349128872 scopus 로고    scopus 로고
    • Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder
    • Clayton EH, Hanstock TL, Hirneth SJ, Kable CJ, Garg ML, Hazell PL. Long-chain omega-3 polyunsaturated fatty acids in the blood of children and adolescents with juvenile bipolar disorder. Lipids 2008;43:1031-1038.
    • (2008) Lipids , vol.43 , pp. 1031-1038
    • Clayton, E.H.1    Hanstock, T.L.2    Hirneth, S.J.3    Kable, C.J.4    Garg, M.L.5    Hazell, P.L.6
  • 40
    • 0942266344 scopus 로고    scopus 로고
    • Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients
    • Sobczak S, Honig A, Christophe A, Maes M, Helsdingen RW, De Vriese SA, et al. Lower high-density lipoprotein cholesterol and increased omega-6 polyunsaturated fatty acids in first-degree relatives of bipolar patients. Psychol Med 2004;34:103-112.
    • (2004) Psychol Med , vol.34 , pp. 103-112
    • Sobczak, S.1    Honig, A.2    Christophe, A.3    Maes, M.4    Helsdingen, R.W.5    De Vriese, S.A.6
  • 42
    • 0034222026 scopus 로고    scopus 로고
    • Are omega3 fatty acids beneficial in depression but not mania
    • Su KP, Shen WW, Huang SY. Are omega3 fatty acids beneficial in depression but not mania? Arch Gen Psychiatry 2000;57:716-717.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 716-717
    • Su, K.P.1    Shen, W.W.2    Huang, S.Y.3
  • 43
    • 21744433505 scopus 로고    scopus 로고
    • Omega-3 eicosapentaenoic acid in bipolar depression: Report of a small open-label study
    • Osher Y, Bersudsky Y, Belmaker RH. Omega-3 eicosapentaenoic acid in bipolar depression: report of a small open-label study. J Clin Psychiatry 2005;66:726-729.
    • (2005) J Clin Psychiatry , vol.66 , pp. 726-729
    • Osher, Y.1    Bersudsky, Y.2    Belmaker, R.H.3
  • 44
    • 15244350377 scopus 로고    scopus 로고
    • Omega-3 fatty acids decreased irritability of patients with bipolar disorder in an add-on, open label study
    • Sagduyu K, Dokucu ME, Eddy BA, Craigen G, Baldassano CF, Yildiz A. Omega-3 fatty acids decreased irritability of patients with bipolar disorder in an add-on, open label study. Nutr J 2005;4:6.
    • (2005) Nutr J , vol.4 , pp. 6
    • Sagduyu, K.1    Dokucu, M.E.2    Eddy, B.A.3    Craigen, G.4    Baldassano, C.F.5    Yildiz, A.6
  • 45
    • 29644443167 scopus 로고    scopus 로고
    • Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: Randomised doubleblind placebo-controlled study
    • Frangou S, Lewis M, McCrone P. Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised doubleblind placebo-controlled study. Br J Psychiatry 2006;188: 46-50.
    • (2006) Br J Psychiatry , vol.188 , pp. 46-50
    • Frangou, S.1    Lewis, M.2    McCrone, P.3
  • 46
    • 68549113124 scopus 로고    scopus 로고
    • Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation
    • Clayton EH, Hanstock TL, Hirneth SJ, Kable CJ, Garg ML, Hazell PL. Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation. Eur J Clin Nutr 2009;63:1037-1040.
    • (2009) Eur J Clin Nutr , vol.63 , pp. 1037-1040
    • Clayton, E.H.1    Hanstock, T.L.2    Hirneth, S.J.3    Kable, C.J.4    Garg, M.L.5    Hazell, P.L.6
  • 47
    • 34447564983 scopus 로고    scopus 로고
    • Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder
    • Frangou S, Lewis M, Wollard J, Simmons A. Preliminary in vivo evidence of increased N-acetyl-aspartate following eicosapentanoic acid treatment in patients with bipolar disorder. J Psychopharmacol 2007;21:435-439.
    • (2007) J Psychopharmacol , vol.21 , pp. 435-439
    • Frangou, S.1    Lewis, M.2    Wollard, J.3    Simmons, A.4
  • 48
    • 33750483012 scopus 로고    scopus 로고
    • Double-blind, randomized, placebocontrolled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    • Keck PE Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, et al. Double-blind, randomized, placebocontrolled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder. Biol Psychiatry 2006;60:1020-1022.
    • (2006) Biol Psychiatry , vol.60 , pp. 1020-1022
    • Keck, P.E.1    Mintz, J.2    McElroy, S.L.3    Freeman, M.P.4    Suppes, T.5    Frye, M.A.6
  • 50
    • 77953775769 scopus 로고    scopus 로고
    • Complementary and alternative medicine for major depressive disorder: A meta-analysis of patient characteristics, placebo-response rates, and treatment outcomes relative to standard antidepressants
    • Freeman MP, Mischoulon D, Tedeschini E, Goodness T, Cohen LS, Fava M, et al. Complementary and alternative medicine for major depressive disorder: a meta-analysis of patient characteristics, placebo-response rates, and treatment outcomes relative to standard antidepressants. J Clin Psychiatry 2010;71:682-688.
    • (2010) J Clin Psychiatry , vol.71 , pp. 682-688
    • Freeman, M.P.1    Mischoulon, D.2    Tedeschini, E.3    Goodness, T.4    Cohen, L.S.5    Fava, M.6
  • 51
    • 84555220604 scopus 로고    scopus 로고
    • Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression
    • Sublette ME, Ellis SP, Geant AL, Mann JJ. Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression. J Clin Psychiatry 2011;72:1577-1584.
    • (2011) J Clin Psychiatry , vol.72 , pp. 1577-1584
    • Sublette, M.E.1    Ellis, S.P.2    Geant, A.L.3    Mann, J.J.4
  • 52
    • 84870065602 scopus 로고    scopus 로고
    • Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: A critique of Bloch and Hannestad and updated metaanalysis
    • Martins JG, Bentsen H, Puri BK. Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated metaanalysis. Mol Psychiatry 2012;17:1144-1149.
    • (2012) Mol Psychiatry , vol.17 , pp. 1144-1149
    • Martins, J.G.1    Bentsen, H.2    Puri, B.K.3
  • 53
    • 84870061968 scopus 로고    scopus 로고
    • Are omega-3 fatty acids antidepressants or just mood-improving agents? the effect depends upon diagnosis, supplement preparation, and severity of depression
    • Lin PY, Mischoulon D, Freeman MP, Matsuoka Y, Hibbeln J, Belmaker RH, et al. Are omega-3 fatty acids antidepressants or just mood-improving agents? The effect depends upon diagnosis, supplement preparation, and severity of depression. Mol Psychiatry 2012;17:1161-1163.
    • (2012) Mol Psychiatry , vol.17 , pp. 1161-1163
    • Lin, P.Y.1    Mischoulon, D.2    Freeman, M.P.3    Matsuoka, Y.4    Hibbeln, J.5    Belmaker, R.H.6
  • 56
    • 85047698720 scopus 로고    scopus 로고
    • Omega-3 treatment of childhood depression: A controlled, double-blind pilot study
    • Nemets H, Nemets B, Apter A, Bracha Z, Belmaker RH. Omega-3 treatment of childhood depression: a controlled, double-blind pilot study. Am J Psychiatry 2006;163:1098-1100.
    • (2006) Am J Psychiatry , vol.163 , pp. 1098-1100
    • Nemets, H.1    Nemets, B.2    Apter, A.3    Bracha, Z.4    Belmaker, R.H.5
  • 57
    • 0036790628 scopus 로고    scopus 로고
    • A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs
    • Peet M, Horrobin DF. A dose-ranging study of the effects of ethyl-eicosapentaenoate in patients with ongoing depression despite apparently adequate treatment with standard drugs. Arch Gen Psychiatry 2002;59:913-919.
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 913-919
    • Peet, M.1    Horrobin, D.F.2
  • 58
    • 0036190807 scopus 로고    scopus 로고
    • Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder
    • Nemets B, Stahl Z, Belmaker RH. Addition of omega-3 fatty acid to maintenance medication treatment for recurrent unipolar depressive disorder. Am J Psychiatry 2002;159:477-479.
    • (2002) Am J Psychiatry , vol.159 , pp. 477-479
    • Nemets, B.1    Stahl, Z.2    Belmaker, R.H.3
  • 59
    • 0042850504 scopus 로고    scopus 로고
    • Omega-3 fatty acids in major depressive disorder,a preliminary doubleblind, placebo-controlled trial
    • Su KP, Huang SY, Chiu CC, Shen WW. Omega-3 fatty acids in major depressive disorder. A preliminary doubleblind, placebo-controlled trial. Eur Neuropsychopharmacol 2003;13:267-271.
    • (2003) Eur Neuropsychopharmacol , vol.13 , pp. 267-271
    • Su, K.P.1    Huang, S.Y.2    Chiu, C.C.3    Shen, W.W.4
  • 60
    • 84950170862 scopus 로고    scopus 로고
    • Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A 6-month randomised controlled trial
    • Sinn N, Milte CM, Street SJ, Buckley JD, Coates AM, Petkov J, et al. Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: a 6-month randomised controlled trial. Br J Nutr 2012; 107:1682-1693.
    • (2012) Br J Nutr , vol.107 , pp. 1682-1693
    • Sinn, N.1    Milte, C.M.2    Street, S.J.3    Buckley, J.D.4    Coates, A.M.5    Petkov, J.6
  • 61
    • 39049148835 scopus 로고    scopus 로고
    • Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder
    • Jazayeri S, Tehrani-Doost M, Keshavarz SA, Hosseini M, Djazayery A, Amini H, et al. Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Aust N Z J Psychiatry 2008;42:192-198.
    • (2008) Aust N Z J Psychiatry , vol.42 , pp. 192-198
    • Jazayeri, S.1    Tehrani-Doost, M.2    Keshavarz, S.A.3    Hosseini, M.4    Djazayery, A.5    Amini, H.6
  • 62
    • 77749291973 scopus 로고    scopus 로고
    • Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood
    • Appleton KM, Rogers PJ, Ness AR. Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood. Am J Clin Nutr 2010;91:757-770.
    • (2010) Am J Clin Nutr , vol.91 , pp. 757-770
    • Appleton, K.M.1    Rogers, P.J.2    Ness, A.R.3
  • 63
    • 38049182755 scopus 로고    scopus 로고
    • No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: A randomised controlled trial
    • Rogers PJ, Appleton KM, Kessler D, Peters TJ, Gunnell D, Hayward RC, et al. No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. Br J Nutr 2008;99:421-431.
    • (2008) Br J Nutr , vol.99 , pp. 421-431
    • Rogers, P.J.1    Appleton, K.M.2    Kessler, D.3    Peters, T.J.4    Gunnell, D.5    Hayward, R.C.6
  • 64
    • 84870062132 scopus 로고    scopus 로고
    • Omega-3 fatty acids for the treatment of depression: Systematic review and meta-analysis
    • Bloch MH, Hannestad J. Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis. Mol Psychiatry 2012;17:1272-1282.
    • (2012) Mol Psychiatry , vol.17 , pp. 1272-1282
    • Bloch, M.H.1    Hannestad, J.2
  • 65
    • 38049125124 scopus 로고    scopus 로고
    • N-3 Fatty acids and mood: The devil is in the detail
    • Richardson AJ. n-3 Fatty acids and mood: the devil is in the detail. Br J Nutr 2008;99:221-223.
    • (2008) Br J Nutr , vol.99 , pp. 221-223
    • Richardson, A.J.1
  • 66
    • 13444254125 scopus 로고    scopus 로고
    • Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats
    • Carlezon WA Jr, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry 2005;57:343-350.
    • (2005) Biol Psychiatry , vol.57 , pp. 343-350
    • Carlezon, W.A.1    Mague, S.D.2    Parow, A.M.3    Stoll, A.L.4    Cohen, B.M.5    Renshaw, P.F.6
  • 68
    • 58149385209 scopus 로고    scopus 로고
    • Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: Effects of chronic ethyl-eicosapentaenoate treatment
    • Song C, Zhang XY, Manku M. Increased phospholipase A2 activity and inflammatory response but decreased nerve growth factor expression in the olfactory bulbectomized rat model of depression: effects of chronic ethyl-eicosapentaenoate treatment. J Neurosci 2009;29:14-22.
    • (2009) J Neurosci , vol.29 , pp. 14-22
    • Song, C.1    Zhang, X.Y.2    Manku, M.3
  • 69
  • 70
    • 84875660794 scopus 로고    scopus 로고
    • Interferon induces nitric oxide synthase expression and haem oxygenase-1 downregulation in microglia: Implications of cellular mechanism of IFN -induced depression
    • Lu DY, Leung YM, Su KP. Interferon induces nitric oxide synthase expression and haem oxygenase-1 downregulation in microglia: implications of cellular mechanism of IFN -induced depression. Int J Neuropsychopharmacol 2013;16:433-444.
    • (2013) Int J Neuropsychopharmacol , vol.16 , pp. 433-444
    • Lu, D.Y.1    Leung, Y.M.2    Su, K.P.3
  • 71
    • 31444441701 scopus 로고    scopus 로고
    • New approaches to antidepressant drug discovery: Beyond monoamines
    • Berton O, Nestler EJ. New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 2006;7:137-151.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 137-151
    • Berton, O.1    Nestler, E.J.2
  • 73
    • 84922681351 scopus 로고    scopus 로고
    • Omega-3 fatty acids in the prevention of interferonalpha-induced depression: Results from a randomized, controlled trial
    • Su KP, Lai HC, Yang HT, Su WP, Peng CY, Chang JP, et al. Omega-3 fatty acids in the prevention of interferonalpha-induced depression: results from a randomized, controlled trial. Biol Psychiatry 2014;76:559-566.
    • (2014) Biol Psychiatry , vol.76 , pp. 559-566
    • Su, K.P.1    Lai, H.C.2    Yang, H.T.3    Su, W.P.4    Peng, C.Y.5    Chang, J.P.6
  • 74
    • 13744265417 scopus 로고    scopus 로고
    • Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: A population-based cohort study
    • Dalton SO, Johansen C, Mellemkjaer L, Nørgard B, Sørensen HT, Olsen JH. Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding: a population-based cohort study. Arch Intern Med 2003;163:59-64.
    • (2003) Arch Intern Med , vol.163 , pp. 59-64
    • Dalton, S.O.1    Johansen, C.2    Mellemkjaer, L.3    Nørgard, B.4    Sørensen, H.T.5    Olsen, J.H.6
  • 78
    • 34247504755 scopus 로고    scopus 로고
    • A randomized trial of paroxetine to prevent interferon-alpha-induced depression in patients with hepatitis C
    • Morasco BJ, Rifai MA, Loftis JM, Indest DW, Moles JK, Hauser P. A randomized trial of paroxetine to prevent interferon-alpha-induced depression in patients with hepatitis C. J Affect Disord 2007;103:83-90.
    • (2007) J Affect Disord , vol.103 , pp. 83-90
    • Morasco, B.J.1    Rifai, M.A.2    Loftis, J.M.3    Indest, D.W.4    Moles, J.K.5    Hauser, P.6
  • 79
    • 34250694821 scopus 로고    scopus 로고
    • Manic episode associated with citalopram therapy for interferoninduced depression in a patient with chronic hepatitis C infection
    • Wu PL, Liao KF, Peng CY, Pariante CM, Su KP. Manic episode associated with citalopram therapy for interferoninduced depression in a patient with chronic hepatitis C infection. Gen Hosp Psychiatry 2007;29:374-376.
    • (2007) Gen Hosp Psychiatry , vol.29 , pp. 374-376
    • Wu, P.L.1    Liao, K.F.2    Peng, C.Y.3    Pariante, C.M.4    Su, K.P.5
  • 80
    • 33847054767 scopus 로고    scopus 로고
    • Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: Involved with PLA2 activity and corticosterone secretion
    • Song C, Li X, Kang Z, Kadotomi Y. Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion. Neuropsychopharmacology 2007;32:736-744.
    • (2007) Neuropsychopharmacology , vol.32 , pp. 736-744
    • Song, C.1    Li, X.2    Kang, Z.3    Kadotomi, Y.4
  • 81
    • 0242322439 scopus 로고    scopus 로고
    • Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats
    • Song C, Li X, Leonard BE, Horrobin DF. Effects of dietary n-3 or n-6 fatty acids on interleukin-1beta-induced anxiety, stress, and inflammatory responses in rats. J Lipid Res 2003;44:1984-1991.
    • (2003) J Lipid Res , vol.44 , pp. 1984-1991
    • Song, C.1    Li, X.2    Leonard, B.E.3    Horrobin, D.F.4
  • 82
    • 1542285471 scopus 로고    scopus 로고
    • A placebo-controlled cross-over trial of adjunctive EPA in OCD
    • Fux M, Benjamin J, Nemets B. A placebo-controlled cross-over trial of adjunctive EPA in OCD. J Psychiatr Res 2004;38:323-325.
    • (2004) J Psychiatr Res , vol.38 , pp. 323-325
    • Fux, M.1    Benjamin, J.2    Nemets, B.3
  • 83
    • 50149114198 scopus 로고    scopus 로고
    • Possible deleterious effects of adjunctive omega-3 fatty acids in post-traumatic stress disorder patients
    • Zeev K, Michael M, Ram K, Hagit C. Possible deleterious effects of adjunctive omega-3 fatty acids in post-traumatic stress disorder patients. Neuropsychiatr Dis Treat 2005; 1:187-190.
    • (2005) Neuropsychiatr Dis Treat , vol.1 , pp. 187-190
    • Zeev, K.1    Michael, M.2    Ram, K.3    Hagit, C.4
  • 84
    • 38749137406 scopus 로고    scopus 로고
    • Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers
    • Buydens-Branchey L, Branchey M, Hibbeln JR. Associations between increases in plasma n-3 polyunsaturated fatty acids following supplementation and decreases in anger and anxiety in substance abusers. Prog Neuropsychopharmacol Biol Psychiatry 2008;32:568-575.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 568-575
    • Buydens-Branchey, L.1    Branchey, M.2    Hibbeln, J.R.3
  • 85
    • 84875775482 scopus 로고    scopus 로고
    • Effects of n-3 polyunsaturated fatty acids on depressive symptoms, anxiety and emotional state in patients with acute myocardial infarction
    • Haberka M, Mizia-Stec K, Mizia M, Gieszczyk K, Chmiel A, Sitnik-Warchulska K, et al. Effects of n-3 polyunsaturated fatty acids on depressive symptoms, anxiety and emotional state in patients with acute myocardial infarction. Pharmacol Rep 2013;65:59-68.
    • (2013) Pharmacol Rep , vol.65 , pp. 59-68
    • Haberka, M.1    Mizia-Stec, K.2    Mizia, M.3    Gieszczyk, K.4    Chmiel, A.5    Sitnik-Warchulska, K.6
  • 86
    • 80053907743 scopus 로고    scopus 로고
    • Omega-3 supplementation lowers inflammation and anxiety in medical students: A randomized controlled trial
    • Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun 2011;25:1725-1734.
    • (2011) Brain Behav Immun , vol.25 , pp. 1725-1734
    • Kiecolt-Glaser, J.K.1    Belury, M.A.2    Andridge, R.3    Malarkey, W.B.4    Glaser, R.5
  • 87
    • 77952124303 scopus 로고    scopus 로고
    • Omega-3 fatty acids for secondary prevention of posttraumatic stress disorder after accidental injury: An open-label pilot study
    • Matsuoka Y, Nishi D, Yonemoto N, Hamazaki K, Hashimoto K, Hamazaki T. Omega-3 fatty acids for secondary prevention of posttraumatic stress disorder after accidental injury: an open-label pilot study. J Clin Psychopharmacol 2010;30:217-219.
    • (2010) J Clin Psychopharmacol , vol.30 , pp. 217-219
    • Matsuoka, Y.1    Nishi, D.2    Yonemoto, N.3    Hamazaki, K.4    Hashimoto, K.5    Hamazaki, T.6
  • 88
    • 84864413985 scopus 로고    scopus 로고
    • Fish oil for attenuating posttraumatic stress symptoms among rescue workers after the great east Japan earthquake: A randomized controlled trial
    • Nishi D, Koido Y, Nakaya N, Sone T, Noguchi H, Hamazaki K, et al. Fish oil for attenuating posttraumatic stress symptoms among rescue workers after the great east Japan earthquake: a randomized controlled trial. Psychother Psychosom 2012;81:315-317.
    • (2012) Psychother Psychosom , vol.81 , pp. 315-317
    • Nishi, D.1    Koido, Y.2    Nakaya, N.3    Sone, T.4    Noguchi, H.5    Hamazaki, K.6
  • 89
    • 0028670265 scopus 로고
    • Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats
    • Delion S, Chalon S, Hérault J, Guilloteau D, Besnard JC, Durand G. Chronic dietary alpha-linolenic acid deficiency alters dopaminergic and serotoninergic neurotransmission in rats. J Nutr 1994;124:2466-2476.
    • (1994) J Nutr , vol.124 , pp. 2466-2476
    • Delion, S.1    Chalon, S.2    Hérault, J.3    Guilloteau, D.4    Besnard, J.C.5    Durand, G.6
  • 90
    • 0035173850 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids and cerebral function: Focus on monoaminergic neurotransmission
    • Chalon S, Vancassel S, Zimmer L, Guilloteau D, Durand G. Polyunsaturated fatty acids and cerebral function: focus on monoaminergic neurotransmission. Lipids 2001;36: 937-944.
    • (2001) Lipids , vol.36 , pp. 937-944
    • Chalon, S.1    Vancassel, S.2    Zimmer, L.3    Guilloteau, D.4    Durand, G.5
  • 91
    • 0029661960 scopus 로고    scopus 로고
    • 5-hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism
    • Berg KA, Maayani S, Clarke WP. 5-hydroxytryptamine2C receptor activation inhibits 5-hydroxytryptamine1B-like receptor function via arachidonic acid metabolism. Mol Pharmacol 1996;50:1017-1023.
    • (1996) Mol Pharmacol , vol.50 , pp. 1017-1023
    • Berg, K.A.1    Maayani, S.2    Clarke, W.P.3
  • 92
    • 0000587671 scopus 로고
    • The serotonin hypothesis of major depression
    • Bloom FE, Kupfer DJ, editors,New York:Raven Press
    • Maes M, Meltzer HYM. The serotonin hypothesis of major depression. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology, the Fourth Generation of Progress. New York:Raven Press;1995. p. 933-941.
    • (1995) Psychopharmacology, the Fourth Generation of Progress , pp. 933-941
    • Maes, M.1    Meltzer, H.Y.M.2
  • 93
    • 0018114827 scopus 로고
    • Brain cortex phospholipids liposomes effects on CSF HVA, 5-HIAA and on prolactin and somatotropin secretion in man
    • Nizzo MC, Tegos S, Gallamini A, Toffano G, Polleri A, Massarotti M. Brain cortex phospholipids liposomes effects on CSF HVA, 5-HIAA and on prolactin and somatotropin secretion in man. J Neural Transm 1978;43:93-102.
    • (1978) J Neural Transm , vol.43 , pp. 93-102
    • Nizzo, M.C.1    Tegos, S.2    Gallamini, A.3    Toffano, G.4    Polleri, A.5    Massarotti, M.6
  • 94
    • 0033232499 scopus 로고    scopus 로고
    • Neural plasticity to stress and antidepressant treatment
    • Duman RS, Malberg J, Thome J. Neural plasticity to stress and antidepressant treatment. Biol Psychiatry 1999;46: 1181-1191.
    • (1999) Biol Psychiatry , vol.46 , pp. 1181-1191
    • Duman, R.S.1    Malberg, J.2    Thome, J.3
  • 95
    • 0042528720 scopus 로고    scopus 로고
    • Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    • Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 2003;301:805-809.
    • (2003) Science , vol.301 , pp. 805-809
    • Santarelli, L.1    Saxe, M.2    Gross, C.3    Surget, A.4    Battaglia, F.5    Dulawa, S.6
  • 97
    • 33646138943 scopus 로고    scopus 로고
    • Docosahexaenoic acid promotes neurogenesis in vitro and in vivo
    • Kawakita E, Hashimoto M, Shido O. Docosahexaenoic acid promotes neurogenesis in vitro and in vivo. Neuroscience 2006;139:991-997.
    • (2006) Neuroscience , vol.139 , pp. 991-997
    • Kawakita, E.1    Hashimoto, M.2    Shido, O.3
  • 98
    • 70350066366 scopus 로고    scopus 로고
    • Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: A versatile potential therapy for stroke
    • Blondeau N, Nguemeni C, Debruyne DN, Piens M, Wu X, Pan H, et al. Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke. Neuropsychopharmacology 2009;34:2548-2559.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 2548-2559
    • Blondeau, N.1    Nguemeni, C.2    Debruyne, D.N.3    Piens, M.4    Wu, X.5    Pan, H.6
  • 99
    • 58249127595 scopus 로고    scopus 로고
    • PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus
    • Venna VR, Deplanque D, Allet C, Belarbi K, Hamdane M, Bordet R. PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus. Psychoneuroendocrinology 2009;34:199-211.
    • (2009) Psychoneuroendocrinology , vol.34 , pp. 199-211
    • Venna, V.R.1    Deplanque, D.2    Allet, C.3    Belarbi, K.4    Hamdane, M.5    Bordet, R.6
  • 100
    • 7244240590 scopus 로고    scopus 로고
    • Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats
    • Wu A, Ying Z, Gomez-Pinilla F. Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats. J Neurotrauma 2004;21:1457-1467.
    • (2004) J Neurotrauma , vol.21 , pp. 1457-1467
    • Wu, A.1    Ying, Z.2    Gomez-Pinilla, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.