Synthesis and biological evaluation of 2- and 7-substituted 9-deazaadenosine analogues

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 1, 2005, Pages 45-62

  Liu, Mao Chin ^a   Luo, Mei Zhen ^a   Mozdziesz, Diane E ^a   Sartorelli, Alan C ^a  

^a YALE CANCER CENTER   (United States)

Author keywords

2 and 7 substituted 9 deazaadenosines; C Glucosylation; Cytotoxic activity; New synthetic method for 9 deazaadenosine analogues

Indexed keywords

2,4 DICHLORO 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 5 (3 METHOXYBENZYL) 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 5 (4 METHYLBENZYL) 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 5 BENZYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 5 CYCLOPROPYLMETHYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 5 METHYL 7 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 5 METHYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 7 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 CHLORO 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 FLUORO 5 BENZYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 2 FLUORO 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 5 4 (METHYLBENZYL) 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 5 BENZYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 5 CYCLOPROPYLMETHYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 5 METHYL 7 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 5 METHYL 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; 4 AMINO 7 (2 DEOXY BETA DEXTRO RIBOFURANOSYL) 5H PYRROLO[3,2 D]PYRIMIDINE; 4 CHLORO 2 FLUORO 7 BETA DEXTRO RIBOFURANOSYL 5H PYRROLO[3,2 D]PYRIMIDINE; ADENOSINE DERIVATIVE; UNCLASSIFIED DRUG;

AMMONOLYSIS; ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CATALYSIS; CHLORINATION; CONTROLLED STUDY; CYTOTOXICITY; DEPROTECTION REACTION; DIAZOTIZATION; DRUG ACTIVITY; DRUG SYNTHESIS; GLYCOSYLATION; HUMAN; HUMAN CELL; HYDROGENATION; IC 50; LEUKEMIA L 1210; LEUKEMIA P 388; LYMPHATIC LEUKEMIA; MELANOMA B16; MOUSE; NONHUMAN;

ANTINEOPLASTIC AGENTS; HUMANS; INHIBITORY CONCENTRATION 50; LEUKEMIA, EXPERIMENTAL; MELANOMA; PURINE NUCLEOSIDES; TUBERCIDIN; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 13144285694     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200046784     Document Type: Article

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