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Volumn 46, Issue 7, 2011, Pages 2770-2785
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The new 5- or 6-azapyrimidine and cyanuric acid derivatives of l-ascorbic acid bearing the free C-5 hydroxy or C-4 amino group at the ethylenic spacer: CD-spectral absolute configuration determination and biological activity evaluations
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b,c
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Author keywords
Cell cycle analysis; Circular dichroism; Cytostatic activity evaluation; l ascorbic acid; Pyrimidine and cyanuric acid derivatives; X ray diffraction
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Indexed keywords
1 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 1H PYRIMIDINE 2,4 DIONE;
1 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 5 FLUORO 1H PYRIMIDINE 2,4 DIONE;
1 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 5 METHYL 1H PYRIMIDINE 2,4 DIONE;
1 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] [1,3,5]TRIAZINANE 2,4,6 TRIONE;
1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) 2 HYDROXY ETHYL] [1,3,5]TRIAZINANE 2,4,6 TRIONE;
1 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] [1,3,5]TRIAZINANE 2,4,6 TRIONE;
1 [2 (3,4 DIHYDROXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] [1,3,5]TRIAZINANE 2,4,6 TRIONE;
2 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 2H [1,2,4]TRIAZINE 3,5 DIONE;
2 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) 2 HYDROXY ETHYL] 2H [1,2,4]TRIAZINE 3,5 DIONE;
2 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 2H [1,2,4]TRIAZINE 3,5 DIONE;
2,3 DI O BENZYL 4,5 DIDEHYDRO 5,6 DIDEOXY LEVO ASCORBIC ACID;
4 AMINO 1 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 1H [1,3,5]TRIAZIN 2 ONE;
4 AMINO 1 [2 (2 AMINO 3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) ETHYL] 1H PYRIMIDIN 2 ONE;
4 AMINO 1 [2 (3 BENZYLOXY 4 HYDROXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 1H [1,3,5]TRIAZIN 2 ONE;
4 AMINO 1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) 2 HYDROXY ETHYL] 1H [1,3,5]TRIAZIN 2 ONE;
4 AMINO 1 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL 1H [1,3,5]TRIAZIN 2 ONE;
4 AMINO 1 [2 (3,4 DIHYDROXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 1H PYRIMIDIN 2 ONE;
4 AMINO 1[2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) 2 HYDROX ETHYL] 1H PYRIMIDIN 2 ONE;
4,5 DIDEHYDRO 5,6 DIDEOXY LEVO ASCORBIC ACID;
ASCORBIC ACID DERIVATIVE;
AZAURACIL;
BENZAMIDE DERIVATIVE;
CYANURIC ACID;
CYTOSINE;
LACTONE;
N [1 [2 (3,4 BIS BENZYLOXY 5 OXO 2,5 DIHYDRO FURAN 2 YL) 2 HYDROXY ETHYL] 2 OXO 1,2 DIHYDRO PYRIMIDIN 4 YL] BENZAMIDE;
N [1 [2 (3,4 BIS BENZYLOXY 5 OXO 5H FURAN 2 YLIDENE) ETHYL] 2 OXO 1,2 DIHYDRO PYRIMIDIN 4 YL] BENZAMIDE;
PYRIMIDINE DERIVATIVE;
TRIAZINE DERIVATIVE;
UNCLASSIFIED DRUG;
URACIL;
ASCORBIC ACID;
CYTOSTATIC AGENT;
ARTICLE;
BIOLOGICAL ACTIVITY;
CELL CYCLE ARREST;
CELL CYCLE PROGRESSION;
CELL POPULATION;
CELL STRAIN HEPG2;
CELL STRAIN MCF 7;
CIRCULAR DICHROISM;
CRYSTAL STRUCTURE;
CYTOSTASIS;
CYTOTOXICITY;
ENANTIOMER;
FIBROBLAST;
FLOW CYTOMETRY;
HELA CELL;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
PROTON NUCLEAR MAGNETIC RESONANCE;
RACEMIC MIXTURE;
STEREOCHEMISTRY;
SYNTHESIS;
X RAY CRYSTALLOGRAPHY;
ANALOGS AND DERIVATIVES;
CELL LINE;
DRUG EFFECTS;
HELA CELL LINE;
HEPG2 CELL LINE;
IC50;
MCF 7 CELL LINE;
S PHASE CELL CYCLE CHECKPOINT;
STEREOISOMERISM;
STRUCTURE ACTIVITY RELATION;
ASCORBIC ACID;
CELL LINE;
CRYSTALLOGRAPHY, X-RAY;
CYTOSINE;
CYTOSTATIC AGENTS;
FIBROBLASTS;
HELA CELLS;
HEP G2 CELLS;
HUMANS;
HYDROGEN BONDING;
INHIBITORY CONCENTRATION 50;
MCF-7 CELLS;
S PHASE CELL CYCLE CHECKPOINTS;
STEREOISOMERISM;
STRUCTURE-ACTIVITY RELATIONSHIP;
TRIAZINES;
URACIL;
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EID: 79957446656
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2011.03.066 Document Type: Article |
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Times cited : (14)
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References (43)
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