Synthesis and antiviral activity of 2′-deoxy-2′-fluoro- 2′-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5′-triphosphates

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7094-7098

  Shi, Junxing ^a   Zhou, Longhu ^b,c   Zhang, Hongwang ^b,c   McBrayer, Tamara R ^a   Detorio, Mervi A ^b,c   Johns, Melissa ^b,c   Bassit, Leda ^b,c   Powdrill, Megan H ^d   Whitaker, Tony ^a   Coats, Steven J ^a   Götte, Matthias ^d   Schinazi, Raymond F ^b,c  

^a RFS Pharma LLC   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

7 Deazapurine; Antiviral; HCV; Mitsunobu; Nucleoside; Nucleotide; Prodrug

Indexed keywords

2' DEOXY 2' FLUORO 2' C METHYL 7 DEAZAPURINE NUCLEOSIDE DERIVATIVE; ANTIVIRUS AGENT; NUCLEOSIDE ANALOG; PHOSPHORAMIDIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG SYNTHESIS; HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; NONHUMAN; PHOSPHORYLATION;

AMIDES; ANTIVIRAL AGENTS; CELL LINE; FLUORINE; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NUCLEOSIDES; PHOSPHORIC ACIDS; PRODRUGS; PURINES; VIRUS REPLICATION;

HEPATITIS C VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 80255138638     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.089     Document Type: Article

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