Synthesis and antiviral and cytostatic evaluations of the new c-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4′,5′-didehydro-L- ascorbic acid derivatives

Journal of Medicinal Chemistry

Volumn 50, Issue 17, 2007, Pages 4105-4112

  Gazivoda, Tatjana ^a   Šokčević, Mario ^a   Kralj, Marijeta ^b   Šuman, Lidija ^b   Pavelić, Krešimir ^b   De Clercq, Erik ^c   Andrei, Graciela ^c   Snoeck, Robert ^c   Balzarini, Jan ^c   Mintas, Mladen ^a   Raić Malić, Silvana ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b RUDER BO KOVI INSTITUTE   (Croatia)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 (6 BUTYLFURO[2,3 D]PYRIMIDIN 2 ON 3 YL) 2 (2',3' DI O BENZYL 2' BUTEN 4' OLIDYLIDENE)ETHANE; 1 (6 HEXYLFURO[2,3 D]PYRIMIDIN 2 ON 3 YL) 2 (2',3' DI O BENZYL 2' BUTEN 4' OLIDYLIDENE)ETHANE; 1 [5 (4 BROMOPHENYLETHYN 1'' YL)URACIL 1 YL] 2 (2',3' DI O BENZYL 2' BUTEN 4' OLIDYLIDENE)ETHANE; 1 [5 (4'' PHENYLBUT 1'' YN 1'' YL)URACIL 1 YL] 2 (2',3' DI O BENZYL 2' BUTEN 4' OLIDYLIDENE)ETHANE; 1 [6 (4 BROMOPHENYL)FURO[2,3 D]PYRIMIDIN 2 ON 3 YL] 2 (2',3' DI O BENZYL 2' BUTEN 4' OLIDYLIDENE)ETHANE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; ACICLOVIR; ALKYNE DERIVATIVE; ALKYNYL GROUP; ASCORBIC ACID DERIVATIVE; BICYCLO COMPOUND; CIDOFOVIR; GANCICLOVIR; IODINE DERIVATIVE; PHENYLACETYLENE; PYRIMIDINE DERIVATIVE; RIBAVIRIN; UNCLASSIFIED DRUG; URACIL DERIVATIVE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOSTASIS; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PARAINFLUENZA VIRUS 3; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS; VESICULAR STOMATITIS VIRUS; VIRUS INHIBITION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; ASCORBIC ACID; CELL LINE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICE; PYRIMIDINES; PYRIMIDINONES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34548136091     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070324z     Document Type: Article

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