Synthesis and biological evaluation of 2′,3′-didehydro- 2′,3-′dideoxy-9-deazaguanosine, a monophosphate prodrug and two analogues, 2′,3′-dideoxy-9-deazaguanosine and 2′,3′- didehydro-2′,3′-dideoxy-9-deazainosine

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 2, 2005, Pages 135-145

  Liu, Mao Chin ^a   Luo, Mei Zhen ^a   Mozdziesz, Diane E ^a   Dutschman, Ginger E ^a   Gullen, Elizabeth A ^a   Cheng, Yung Chi ^a   Sartorelli, Alan C ^a  

^a YALE CANCER CENTER   (United States)

Author keywords

Anti HIV Activity; C Nucleosides; Cytotoxic Activity; Monophosphate Prodrug; Synthesis of Unsaturated 9 Deazanucleosides

Indexed keywords

2',3' DIDEHYDRO 2',3' DIDEOXY 9 DEAZAGUANOSINE; 2',3' DIDEHYDRO 2',3' DIDEOXY 9 DEAZAINOSINE; 2',3' DIDEOXY 9 DEAZAGUANOSINE; ABACAVIR; CARBOVIR; GUANINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATALYSIS; CYTOTOXICITY; DRUG HYDROLYSIS; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS; HYDROGENATION; LEUKEMIA L 1210; MELANOMA B16;

CELL LINE, TUMOR; DEOXYGUANOSINE; HEMATOLOGIC NEOPLASMS; HIV; HUMANS; INOSINE; PRODRUGS;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 15944378807     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-200051898     Document Type: Article

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