TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations

Nature Communications

Volumn 6, Issue , 2015, Pages

  Hua, Fang ^a   Li, Ke ^a,b   Yu, Jiao Jiao ^a   Lv, Xiao Xi ^a   Yan, Jun ^a   Zhang, Xiao Wei ^a   Sun, Wei ^a   Lin, Heng ^a   Shang, Shuang ^a   Wang, Feng ^a   Cui, Bing ^a   Mu, Rong ^a   Huang, Bo ^c   Jiang, Jian Dong ^a,b   Hu, Zhuo Wei ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^c INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; ONCOPROTEIN; PROTEASOME; PROTEIN P62; SOMATOMEDIN; TRB3 PROTEIN; UNCLASSIFIED DRUG; 3-METHYLADENINE; ADENINE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CELL CYCLE PROTEIN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; LEUPEPTIN; PROTEIN SERINE THREONINE KINASE; REPRESSOR PROTEIN; SEQUESTOSOME 1; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SOMATOMEDIN C; SQSTM1 PROTEIN, HUMAN; TRIB3 PROTEIN, HUMAN; UBIQUITIN;

ANTAGONISM; BIOACCUMULATION; BIODEGRADATION; CANCER; CELL ORGANELLE; DIABETES; METABOLISM; MOLECULAR ANALYSIS; PHOSPHORUS; PROTEIN; RODENT; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CELL PROLIFERATION; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; HUMAN TISSUE; MALE; METASTASIS; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; TUMOR INVASION; TUMOR PROMOTION; UBIQUITINATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL MOTION; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUDE MOUSE; PHYSIOLOGY; TISSUE MICROARRAY;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENINE; ANIMALS; AUTOPHAGY; CELL CYCLE PROTEINS; CELL MOVEMENT; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN-LIKE GROWTH FACTOR I; LEUPEPTINS; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASMS, EXPERIMENTAL; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; REPRESSOR PROTEINS; SEQUESTOSOME-1 PROTEIN; TISSUE ARRAY ANALYSIS; UBIQUITIN;

EID: 84939437075     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8951     Document Type: Article

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