Anticancer peptidylarginine deiminase (PAD) inhibitors regulate the autophagy flux and the mammalian target of rapamycin complex 1 activity

Journal of Biological Chemistry

Volumn 287, Issue 31, 2012, Pages 25941-25953

  Wang, Yuji ^a,b   Li, Pingxin ^a   Wang, Shu ^a   Hu, Jing ^a   Chen, Xiangyun Amy ^a   Wu, Jianhui ^a,b   Fisher, Megan ^a   Oshaben, Kira ^a   Zhao, Na ^a   Gu, Ying ^a   Wang, Dong ^c   Chen, Gong ^a   Wang, Yanming ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVERSE EFFECT; ANTI-CANCER REAGENT; AUTOPHAGY; CANCER CELL GROWTH; CANCER CELLS; CANCER GROWTH; CELL CYCLE; COMPLEX 1; COREPRESSORS; GENE EXPRESSION PROFILES; HISTONE DEACETYLASE INHIBITOR; HISTONE MODIFICATION; HUMAN CANCER; MAMMALIAN TARGET; PEPTIDYLARGININE DEIMINASE; SIGNALING PATHWAYS; TUMOR GROWTH; TUMOR SUPPRESSOR GENES;

ANTIBIOTICS; CELL DEATH; DISEASES; ENZYME INHIBITION; LEAD COMPOUNDS; PHOSPHORYLATION; TUMORS;

GENE EXPRESSION;

ANTINEOPLASTIC AGENT; DOXORUBICIN; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PEPTIDYLARGININE DEIMINASE 4; PROTEIN ARGININE DEIMINASE; S6 KINASE; UNCLASSIFIED DRUG; VORINOSTAT; YW 3 56; YW 3 65;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; MACROAUTOPHAGY; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATOR GENE; SARCOMA; SESN2 GENE; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SYNERGISM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONE DEACETYLASE INHIBITORS; HUMANS; HYDROLASES; INHIBITORY CONCENTRATION 50; MICE; NUCLEAR PROTEINS; PROTEINS; SARCOMA; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MAMMALIA;

EID: 84864386137     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.375725     Document Type: Article

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