Bivalent compound 17MN exerts neuroprotection through interaction at multiple sites in a cellular model of Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 47, Issue 4, 2015, Pages 1021-1033

  Liu, Kai ^a   Chojnacki, Jeremy E ^a   Wade, Emily E ^a   Saathoff, John M ^a   Lesnefsky, Edward J ^a   Chen, Qun ^a   Zhang, Shijun ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; Bivalent compound; Calcium; Mitochondria; Multifunctional; Neuroprotection

Indexed keywords

BIVALENT COMPOUND 17MN; CALCIUM; CASPASE 3; NEUROPROTECTIVE AGENT; PROTEIN KINASE; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN KINASE 1; TETRACYCLINE; UNCLASSIFIED DRUG; 17MN COMPOUND; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; CASP3 PROTEIN, HUMAN; CHOLESTEROL; CURCUMIN; PEPTIDE FRAGMENT; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN MITOCHONDRION; CALCIUM MOBILIZATION; CELL DEATH; CELL ORGANELLE; CELL POPULATION; COMPLEX FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NECROPTOSIS; NEUROPROTECTION; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIRATORY CHAIN; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; C57BL MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; HUMAN; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; BRAIN; CALCIUM; CASPASE 3; CELL LINE, TUMOR; CHOLESTEROL; CURCUMIN; ENDOPLASMIC RETICULUM; HUMANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

EID: 84939430198     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150242     Document Type: Article

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