메뉴 건너뛰기




Volumn 405, Issue 1, 2015, Pages 108-122

The role of folate metabolism in orofacial development and clefting

Author keywords

DHFR; Folate; Orofacial development; Retinoic acid and primary palate; Xenopus

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DIHYDROFOLATE REDUCTASE; FOLIC ACID; BIOLOGICAL MARKER; FOLINIC ACID; METHOTREXATE; MORPHOLINO OLIGONUCLEOTIDE; RETINOIC ACID; RETINOIC ACID RECEPTOR;

EID: 84939272236     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2015.07.001     Document Type: Article
Times cited : (45)

References (66)
  • 1
    • 16244423009 scopus 로고    scopus 로고
    • Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts
    • Andersen S., Heine T., Sneve R., Konig I., Krokan H.E., Epe B., Nilsen H. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis 2005, 26:547-555.
    • (2005) Carcinogenesis , vol.26 , pp. 547-555
    • Andersen, S.1    Heine, T.2    Sneve, R.3    Konig, I.4    Krokan, H.E.5    Epe, B.6    Nilsen, H.7
  • 2
    • 53149105108 scopus 로고    scopus 로고
    • Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet
    • Bagnyukova T.V., Powell C.L., Pavliv O., Tryndyak V.P., Pogribny I.P. Induction of oxidative stress and DNA damage in rat brain by a folate/methyl-deficient diet. Brain Res. 2008, 1237:44-51.
    • (2008) Brain Res. , vol.1237 , pp. 44-51
    • Bagnyukova, T.V.1    Powell, C.L.2    Pavliv, O.3    Tryndyak, V.P.4    Pogribny, I.P.5
  • 3
    • 65349083724 scopus 로고    scopus 로고
    • Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview
    • Beaudin A.E., Stover P.J. Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. Birth Defects Res. A Clin. Mol. Teratol. 2009, 85:274-284.
    • (2009) Birth Defects Res. A Clin. Mol. Teratol. , vol.85 , pp. 274-284
    • Beaudin, A.E.1    Stover, P.J.2
  • 6
    • 0036245188 scopus 로고    scopus 로고
    • Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model
    • Burgoon J.M., Selhub J., Nadeau M., Sadler T.W. Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology 2002, 65:219-227.
    • (2002) Teratology , vol.65 , pp. 219-227
    • Burgoon, J.M.1    Selhub, J.2    Nadeau, M.3    Sadler, T.W.4
  • 7
    • 79960141859 scopus 로고    scopus 로고
    • Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects
    • Chang H., Zhang T., Zhang Z., Bao R., Fu C., Wang Z., Bao Y., Li Y., Wu L., Zheng X., Wu J. Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects. J. Nutr. Biochem. 2011, 22:1172-1177.
    • (2011) J. Nutr. Biochem. , vol.22 , pp. 1172-1177
    • Chang, H.1    Zhang, T.2    Zhang, Z.3    Bao, R.4    Fu, C.5    Wang, Z.6    Bao, Y.7    Li, Y.8    Wu, L.9    Zheng, X.10    Wu, J.11
  • 8
    • 14144251552 scopus 로고    scopus 로고
    • Folate supplementation increases genomic DNA methylation in the liver of elder rats
    • Choi S.W., Friso S., Keyes M.K., Mason J.B. Folate supplementation increases genomic DNA methylation in the liver of elder rats. Br. J. Nutr. 2005, 93:31-35.
    • (2005) Br. J. Nutr. , vol.93 , pp. 31-35
    • Choi, S.W.1    Friso, S.2    Keyes, M.K.3    Mason, J.B.4
  • 9
    • 41849147191 scopus 로고    scopus 로고
    • Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines
    • Crott J.W., Liu Z., Keyes M.K., Choi S.W., Jang H., Moyer M.P., Mason J.B. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling and folate uptake in human colonic epithelial cell lines. J. Nutr. Biochem. 2008, 19:328-335.
    • (2008) J. Nutr. Biochem. , vol.19 , pp. 328-335
    • Crott, J.W.1    Liu, Z.2    Keyes, M.K.3    Choi, S.W.4    Jang, H.5    Moyer, M.P.6    Mason, J.B.7
  • 10
    • 78651073326 scopus 로고    scopus 로고
    • Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network
    • de Croze N., Maczkowiak F., Monsoro-Burq A.H. Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network. Proc. Natl. Acad. Sci. USA 2011, 108:155-160.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 155-160
    • de Croze, N.1    Maczkowiak, F.2    Monsoro-Burq, A.H.3
  • 11
    • 84871612518 scopus 로고    scopus 로고
    • Protocol for the single cell gel electrophoresis/comet assay for rapid genotoxicity assessment
    • India
    • Dhawan, A., Bajpayee, M., Pandey, A.K., D., P., Protocol for the single cell gel electrophoresis/comet assay for rapid genotoxicity assessment. Indian Institute of Toxicology Research, India, 2009.
    • (2009) Indian Institute of Toxicology Research
    • Dhawan, A.1    Bajpayee, M.2    Pandey, A.K.D.P.3
  • 12
    • 33745236662 scopus 로고    scopus 로고
    • Development of the primary mouth in Xenopus laevis
    • Dickinson A.J., Sive H. Development of the primary mouth in Xenopus laevis. Dev. Biol. 2006, 295:700-713.
    • (2006) Dev. Biol. , vol.295 , pp. 700-713
    • Dickinson, A.J.1    Sive, H.2
  • 13
    • 67449113924 scopus 로고    scopus 로고
    • The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth
    • Dickinson A.J., Sive H.L. The Wnt antagonists Frzb-1 and Crescent locally regulate basement membrane dissolution in the developing primary mouth. Development 2009, 136:1071-1081.
    • (2009) Development , vol.136 , pp. 1071-1081
    • Dickinson, A.J.1    Sive, H.L.2
  • 14
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35:495-516.
    • (2007) Toxicol. Pathol. , vol.35 , pp. 495-516
    • Elmore, S.1
  • 18
    • 84867866595 scopus 로고    scopus 로고
    • Folic acid supplementation and pregnancy: more than just neural tube defect prevention
    • Greenberg J.A., Bell S.J., Guan Y., Yu Y.H. Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Rev. Obstet. Gynecol. 2011, 4:52-59.
    • (2011) Rev. Obstet. Gynecol. , vol.4 , pp. 52-59
    • Greenberg, J.A.1    Bell, S.J.2    Guan, Y.3    Yu, Y.H.4
  • 19
    • 84887212565 scopus 로고    scopus 로고
    • Relationship between neural crest cells and cranial mesoderm during head muscle development
    • Grenier J., Teillet M.A., Grifone R., Kelly R.G., Duprez D. Relationship between neural crest cells and cranial mesoderm during head muscle development. PLoS One 2009, 4:e4381.
    • (2009) PLoS One , vol.4 , pp. e4381
    • Grenier, J.1    Teillet, M.A.2    Grifone, R.3    Kelly, R.G.4    Duprez, D.5
  • 20
    • 0036089964 scopus 로고    scopus 로고
    • Involvement of DNA mismatch repair in folate deficiency-induced apoptosis small star, filled
    • Gu L., Wu J., Qiu L., Jennings C.D., Li G.M. Involvement of DNA mismatch repair in folate deficiency-induced apoptosis small star, filled. J. Nutr. Biochem. 2002, 13:355-363.
    • (2002) J. Nutr. Biochem. , vol.13 , pp. 355-363
    • Gu, L.1    Wu, J.2    Qiu, L.3    Jennings, C.D.4    Li, G.M.5
  • 21
    • 0035962664 scopus 로고    scopus 로고
    • Histone H3 phosphorylation and cell division
    • Hans F., Dimitrov S. Histone H3 phosphorylation and cell division. Oncogene 2001, 20:3021-3027.
    • (2001) Oncogene , vol.20 , pp. 3021-3027
    • Hans, F.1    Dimitrov, S.2
  • 22
    • 0041833480 scopus 로고    scopus 로고
    • Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine
    • Ho P.I., Ashline D., Dhitavat S., Ortiz D., Collins S.C., Shea T.B., Rogers E. Folate deprivation induces neurodegeneration: roles of oxidative stress and increased homocysteine. Neurobiol. Dis. 2003, 14:32-42.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 32-42
    • Ho, P.I.1    Ashline, D.2    Dhitavat, S.3    Ortiz, D.4    Collins, S.C.5    Shea, T.B.6    Rogers, E.7
  • 24
    • 84904798025 scopus 로고    scopus 로고
    • The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling
    • Jacox L., Sindelka R., Chen J., Rothman A., Dickinson A., Sive H. The extreme anterior domain is an essential craniofacial organizer acting through Kinin-Kallikrein signaling. Cell Rep. 2014, 8:596-609.
    • (2014) Cell Rep. , vol.8 , pp. 596-609
    • Jacox, L.1    Sindelka, R.2    Chen, J.3    Rothman, A.4    Dickinson, A.5    Sive, H.6
  • 26
    • 84908127255 scopus 로고    scopus 로고
    • Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish--implication in neural tube defects and Alzheimer's diseases
    • Kao T.T., Chu C.Y., Lee G.H., Hsiao T.H., Cheng N.W., Chang N.S., Chen B.H., Fu T.F. Folate deficiency-induced oxidative stress contributes to neuropathy in young and aged zebrafish--implication in neural tube defects and Alzheimer's diseases. Neurobiol. Dis. 2014, 71:234-244.
    • (2014) Neurobiol. Dis. , vol.71 , pp. 234-244
    • Kao, T.T.1    Chu, C.Y.2    Lee, G.H.3    Hsiao, T.H.4    Cheng, N.W.5    Chang, N.S.6    Chen, B.H.7    Fu, T.F.8
  • 27
    • 84859436519 scopus 로고    scopus 로고
    • Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes
    • Kennedy A.E., Dickinson A.J. Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes. Dev. Biol. 2012, 365:229-240.
    • (2012) Dev. Biol. , vol.365 , pp. 229-240
    • Kennedy, A.E.1    Dickinson, A.J.2
  • 28
    • 84911384626 scopus 로고    scopus 로고
    • Quantification of orofacial phenotypes in Xenopus
    • Kennedy A.E., Dickinson A.J. Quantification of orofacial phenotypes in Xenopus. J. Vis. Exp. 2014, e52062.
    • (2014) J. Vis. Exp. , pp. e52062
    • Kennedy, A.E.1    Dickinson, A.J.2
  • 29
    • 84899471544 scopus 로고    scopus 로고
    • Quantitative analysis of orofacial development and median clefts in Xenopus laevis
    • Kennedy A.E., Dickinson A.J. Quantitative analysis of orofacial development and median clefts in Xenopus laevis. Anat. Rec. (Hoboken) 2014, 297:834-855.
    • (2014) Anat. Rec. (Hoboken) , vol.297 , pp. 834-855
    • Kennedy, A.E.1    Dickinson, A.J.2
  • 31
    • 0141888296 scopus 로고    scopus 로고
    • Folate deficiency, mismatch repair-dependent apoptosis, and human disease
    • Li G.M., Presnell S.R., Gu L. Folate deficiency, mismatch repair-dependent apoptosis, and human disease. J. Nutr. Biochem. 2003, 14:568-575.
    • (2003) J. Nutr. Biochem. , vol.14 , pp. 568-575
    • Li, G.M.1    Presnell, S.R.2    Gu, L.3
  • 32
    • 80655132048 scopus 로고    scopus 로고
    • Xenopus reduced folate carrier regulates neural crest development epigenetically
    • Li J., Shi Y., Sun J., Zhang Y., Mao B. Xenopus reduced folate carrier regulates neural crest development epigenetically. PLoS One 2011, 6:e27198.
    • (2011) PLoS One , vol.6 , pp. e27198
    • Li, J.1    Shi, Y.2    Sun, J.3    Zhang, Y.4    Mao, B.5
  • 33
    • 0033808685 scopus 로고    scopus 로고
    • Folic acid: nutritional biochemistry, molecular biology, and role in disease processes
    • Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol. Genet. Metab. 2000, 71:121-138.
    • (2000) Mol. Genet. Metab. , vol.71 , pp. 121-138
    • Lucock, M.1
  • 34
    • 77953658106 scopus 로고    scopus 로고
    • Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2
    • Martin S.A., McCarthy A., Barber L.J., Burgess D.J., Parry S., Lord C.J., Ashworth A. Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2. EMBO Mol. Med. 2009, 1:323-337.
    • (2009) EMBO Mol. Med. , vol.1 , pp. 323-337
    • Martin, S.A.1    McCarthy, A.2    Barber, L.J.3    Burgess, D.J.4    Parry, S.5    Lord, C.J.6    Ashworth, A.7
  • 35
    • 80052232047 scopus 로고    scopus 로고
    • Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival
    • Marean A., Graf A., Zhang Y., Niswander L. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum. Mol. Genet. 2011, 20:3678-3683.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3678-3683
    • Marean, A.1    Graf, A.2    Zhang, Y.3    Niswander, L.4
  • 36
    • 84892541873 scopus 로고    scopus 로고
    • Evidence of the involvement of the DHFR gene in nonsyndromic cleft lip with or without cleft palate
    • Martinelli M., Girardi A., Cura F., Carinci F., Morselli P.G., Scapoli L. Evidence of the involvement of the DHFR gene in nonsyndromic cleft lip with or without cleft palate. Eur. J. Med. Genet. 2014, 57:1-4.
    • (2014) Eur. J. Med. Genet. , vol.57 , pp. 1-4
    • Martinelli, M.1    Girardi, A.2    Cura, F.3    Carinci, F.4    Morselli, P.G.5    Scapoli, L.6
  • 37
    • 48249134365 scopus 로고    scopus 로고
    • Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    • (discussion S112-5)
    • Molloy A.M., Kirke P.N., Brody L.C., Scott J.M., Mills J.L. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr. Bull. 2008, 29:S101-S111. (discussion S112-5).
    • (2008) Food Nutr. Bull. , vol.29 , pp. S101-S111
    • Molloy, A.M.1    Kirke, P.N.2    Brody, L.C.3    Scott, J.M.4    Mills, J.L.5
  • 40
    • 33744939698 scopus 로고    scopus 로고
    • The differentiation and morphogenesis of craniofacial muscles
    • Noden D.M., Francis-West P. The differentiation and morphogenesis of craniofacial muscles. Dev. Dyn. 2006, 235:1194-1218.
    • (2006) Dev. Dyn. , vol.235 , pp. 1194-1218
    • Noden, D.M.1    Francis-West, P.2
  • 41
    • 33646187201 scopus 로고    scopus 로고
    • Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells
    • Novakovic P., Stempak J.M., Sohn K.J., Kim Y.I. Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis 2006, 27:916-924.
    • (2006) Carcinogenesis , vol.27 , pp. 916-924
    • Novakovic, P.1    Stempak, J.M.2    Sohn, K.J.3    Kim, Y.I.4
  • 42
    • 77957814604 scopus 로고    scopus 로고
    • Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres
    • O'Sullivan R.J., Kubicek S., Schreiber S.L., Karlseder J. Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres. Nat. Struct. Mol. Biol. 2010, 17:1218-1225.
    • (2010) Nat. Struct. Mol. Biol. , vol.17 , pp. 1218-1225
    • O'Sullivan, R.J.1    Kubicek, S.2    Schreiber, S.L.3    Karlseder, J.4
  • 43
    • 0344142396 scopus 로고    scopus 로고
    • Emerging roles of caspase-3 in apoptosis
    • Porter A.G., Janicke R.U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999, 6:99-104.
    • (1999) Cell Death Differ. , vol.6 , pp. 99-104
    • Porter, A.G.1    Janicke, R.U.2
  • 44
    • 33745280074 scopus 로고    scopus 로고
    • Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates
    • Qi H., Ratnam M. Synergistic induction of folate receptor beta by all-trans retinoic acid and histone deacetylase inhibitors in acute myelogenous leukemia cells: mechanism and utility in enhancing selective growth inhibition by antifolates. Cancer Res. 2006, 66(11):5875-5882.
    • (2006) Cancer Res. , vol.66 , Issue.11 , pp. 5875-5882
    • Qi, H.1    Ratnam, M.2
  • 46
    • 34547146470 scopus 로고    scopus 로고
    • Folate deficiency and plasma homocysteine during increased oxidative stress
    • Rogers E.J., Chen S., Chan A. Folate deficiency and plasma homocysteine during increased oxidative stress. N. Engl. J. Med. 2007, 357:421-422.
    • (2007) N. Engl. J. Med. , vol.357 , pp. 421-422
    • Rogers, E.J.1    Chen, S.2    Chan, A.3
  • 47
    • 84871225043 scopus 로고    scopus 로고
    • Cranial muscles in amphibians: development, novelties and the role of cranial neural crest cells
    • Schmidt J., Piekarski N., Olsson L. Cranial muscles in amphibians: development, novelties and the role of cranial neural crest cells. J. Anat. 2013, 222:134-146.
    • (2013) J. Anat. , vol.222 , pp. 134-146
    • Schmidt, J.1    Piekarski, N.2    Olsson, L.3
  • 48
    • 77952080578 scopus 로고    scopus 로고
    • A new perspective on neural tube defects: folic acid and microRNA misexpression
    • Shookhoff J.M., Gallicano G.I. A new perspective on neural tube defects: folic acid and microRNA misexpression. Genesis 2010, 48:282-294.
    • (2010) Genesis , vol.48 , pp. 282-294
    • Shookhoff, J.M.1    Gallicano, G.I.2
  • 49
    • 84964694912 scopus 로고    scopus 로고
    • Establishing neural crest identity: a gene regulatory recipe
    • Simoes-Costa M., Bronner M.E. Establishing neural crest identity: a gene regulatory recipe. Development 2015, 142:242-257.
    • (2015) Development , vol.142 , pp. 242-257
    • Simoes-Costa, M.1    Bronner, M.E.2
  • 51
    • 1842418999 scopus 로고    scopus 로고
    • Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum
    • Soto M., Iborra S., Quijada L., Folgueira C., Alonso C., Requena J.M. Cell-cycle-dependent translation of histone mRNAs is the key control point for regulation of histone biosynthesis in Leishmania infantum. Biochem. J. 2004, 379:617-625.
    • (2004) Biochem. J. , vol.379 , pp. 617-625
    • Soto, M.1    Iborra, S.2    Quijada, L.3    Folgueira, C.4    Alonso, C.5    Requena, J.M.6
  • 53
    • 82255194162 scopus 로고    scopus 로고
    • Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish
    • Sun S., Gui Y., Jiang Q., Song H. Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish. Acta Biochim. Biophys. Sin. (Shanghai) 2011, 43:957-969.
    • (2011) Acta Biochim. Biophys. Sin. (Shanghai) , vol.43 , pp. 957-969
    • Sun, S.1    Gui, Y.2    Jiang, Q.3    Song, H.4
  • 54
    • 34547577593 scopus 로고    scopus 로고
    • Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development
    • Sun S.N., Gui Y.H., Wang Y.X., Qian L.X., Jiang Q., Liu D., Song H.Y. Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development. Chin. Med. J. (Engl.) 2007, 120:1166-1171.
    • (2007) Chin. Med. J. (Engl.) , vol.120 , pp. 1166-1171
    • Sun, S.N.1    Gui, Y.H.2    Wang, Y.X.3    Qian, L.X.4    Jiang, Q.5    Liu, D.6    Song, H.Y.7
  • 56
  • 57
    • 0000529717 scopus 로고
    • Revised procedures for staining and clearing small fishes and other vertebrates for bone and cartilage study
    • Taylor W., V.D.G. Revised procedures for staining and clearing small fishes and other vertebrates for bone and cartilage study. Cybium 1985, 9:107-119.
    • (1985) Cybium , vol.9 , pp. 107-119
    • Taylor, W.1    Van Dyke, G.2
  • 59
    • 73649119864 scopus 로고    scopus 로고
    • Folic acid and orofacial clefts: a review of the evidence
    • Wehby G.L., Murray J.C. Folic acid and orofacial clefts: a review of the evidence. Oral Dis. 2010, 16:11-19.
    • (2010) Oral Dis. , vol.16 , pp. 11-19
    • Wehby, G.L.1    Murray, J.C.2
  • 60
    • 66349117984 scopus 로고    scopus 로고
    • Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus
    • Wheeler G.N., Brandli A.W. Simple vertebrate models for chemical genetics and drug discovery screens: lessons from zebrafish and Xenopus. Dev. Dyn. 2009, 238:1287-1308.
    • (2009) Dev. Dyn. , vol.238 , pp. 1287-1308
    • Wheeler, G.N.1    Brandli, A.W.2
  • 62
    • 0025895658 scopus 로고
    • Developmental regulation of transcription factor AP-2 during Xenopus laevis embryogenesis
    • Winning R.S., Shea L.J., Marcus S.J., Sargent T.D. Developmental regulation of transcription factor AP-2 during Xenopus laevis embryogenesis. Nucleic Acids Res. 1991, 19:3709-3714.
    • (1991) Nucleic Acids Res. , vol.19 , pp. 3709-3714
    • Winning, R.S.1    Shea, L.J.2    Marcus, S.J.3    Sargent, T.D.4
  • 64
    • 67849103342 scopus 로고    scopus 로고
    • Folate deficiency induces neural stem cell apoptosis by increasing homocysteine in vitro
    • Zhang X.M., Huang G.W., Tian Z.H., Ren D.L., J, X.W. Folate deficiency induces neural stem cell apoptosis by increasing homocysteine in vitro. J. Clin. Biochem. Nutr. 2009, 45:14-19.
    • (2009) J. Clin. Biochem. Nutr. , vol.45 , pp. 14-19
    • Zhang, X.M.1    Huang, G.W.2    Tian, Z.H.3    Ren, D.L.4    Wilson, J.X.5
  • 65
    • 84880698439 scopus 로고    scopus 로고
    • Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability
    • Zhao J., Guan T., Wang J., Xiang Q., Wang M., Wang X., Guan Z., Xie Q., Niu B., Zhang T. Influence of the antifolate drug Methotrexate on the development of murine neural tube defects and genomic instability. J. Appl. Toxicol. 2013, 33:915-923.
    • (2013) J. Appl. Toxicol. , vol.33 , pp. 915-923
    • Zhao, J.1    Guan, T.2    Wang, J.3    Xiang, Q.4    Wang, M.5    Wang, X.6    Guan, Z.7    Xie, Q.8    Niu, B.9    Zhang, T.10
  • 66
    • 0344393780 scopus 로고    scopus 로고
    • Resistance to antifolates
    • Zhao R., Goldman I.D. Resistance to antifolates. Oncogene 2003, 22:7431-7457.
    • (2003) Oncogene , vol.22 , pp. 7431-7457
    • Zhao, R.1    Goldman, I.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.