Influence of the antifolate drug methotrexate on the development of murine neural tube defects and genomic instability

Journal of Applied Toxicology

Volumn 33, Issue 9, 2013, Pages 915-923

  Zhao, Jie ^a   Guan, Tao ^a   Wang, Jianhua ^b   Xiang, Qian ^c   Wang, Mingsheng ^c   Wang, Xiuwei ^b   Guan, Zhen ^b   Xie, Qiu ^b   Niu, Bo ^b   Zhang, Ting ^b  

^a SHANXI MEDICAL UNIVERSITY   (China)

^b CAPITAL INSTITUTE OF PEDIATRICS   (China)

^c PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Development; DNA copy number variations; Methotrexate; Mice; Neural tube defects

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID; GENOMIC DNA; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; EMBRYO; EMBRYONAL TISSUE; ENZYME INHIBITION; FEMALE; FOLATE METABOLISM; GENE DOSAGE; GENOMIC INSTABILITY; GESTATIONAL AGE; LIQUID CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; X CHROMOSOME;

DEVELOPMENT; DNA COPY NUMBER VARIATIONS; METHOTREXATE; MICE; NEURAL TUBE DEFECTS;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; CHROMATOGRAPHY, LIQUID; COMPARATIVE GENOMIC HYBRIDIZATION; DIET; DNA COPY NUMBER VARIATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC DEVELOPMENT; ENZYME INHIBITORS; FEMALE; FOLIC ACID; FOLIC ACID ANTAGONISTS; FOLIC ACID DEFICIENCY; GENOMIC INSTABILITY; MALE; METHOTREXATE; MICE; MICE, INBRED C57BL; NEURAL TUBE; NEURAL TUBE DEFECTS; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY; TETRAHYDROFOLATE DEHYDROGENASE;

MURINAE; MUS;

EID: 84880698439     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.2769     Document Type: Article

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