Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish

Acta Biochimica et Biophysica Sinica

Volumn 43, Issue 12, 2011, Pages 957-969

  Sun, Shuna ^a   Gui, Yonghao ^a   Jiang, Qiu ^a   Song, Houyan ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Cardiac development; Cell proliferation; Dihydrofolate reductase gene; Gene expression; Hedgehog pathway; Zebrafish

Indexed keywords

DIHYDROFOLATE REDUCTASE; MEF2CB PROTEIN, ZEBRAFISH; MUSCLE PROTEIN; NKX2.5 PROTEIN, ZEBRAFISH; T BOX TRANSCRIPTION FACTOR; TBX20 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; ZEBRAFISH PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONGENITAL HEART MALFORMATION; DRUG EFFECT; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; METABOLISM; MICROINJECTION; MOLECULAR GENETICS; PRENATAL DEVELOPMENT; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CELL PROLIFERATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE KNOCKDOWN TECHNIQUES; HEART; HEART DEFECTS, CONGENITAL; MICROINJECTIONS; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; T-BOX DOMAIN PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; TRANSCRIPTION FACTORS; ZEBRAFISH; ZEBRAFISH PROTEINS;

EID: 82255194162     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmr098     Document Type: Article

References (31)

1. Obican SG, Finnell RH, Mills JL, Shaw GM and Scialli AR. Folic acid in early pregnancy: a public health success story. FASEB J 2010, 24: 4167-4174.
2. Hobbs CA, Cleves MA, Karim MA, Zhao W and MacLeod SL. Maternal folate-related gene environment interactions and congenital heart defects. Obstet Gynecol 2010, 116: 316-322.
3. Burgoon JM, Selhub J, Nadeau M and Sadler TW. Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model. Teratology 2002, 65: 219-227. (Pubitemid 34492611)
4. Goldmuntz E, Woyciechowski S, Renstrom D, Lupo PJ and Mitchell LE. Variants of folate metabolism genes and the risk of conotruncal cardiac defects. Circ Cardiovasc Genet 2008, 1: 126-132.
5. Mitchell LE, Long J, Garbarini J, Paluru P and Goldmuntz E. Variants of folate metabolism genes and risk of left-sided cardiac defects. Birth Defects Res A Clin Mol Teratol 2010, 88: 48-53.
6. Hernandez-Diaz S, Werler MM and Walker AM. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 2000, 343: 1608-1614. (Pubitemid 32162984)
7. Bailey LB and Berry RJ. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Am J Clin Nutr 2005, 81: 1213S-1217S. (Pubitemid 41724972)
8. Kalmbach RD, Choumenkovitch SF, Troen AP, Jacques PF, D'Agostino R and Selhub J. A 19-base pair deletion polymorphism in dihydrofolate reductase is associated with increased unmetabolized folic acid in plasma and decreased red blood cell folate. J Nutr 2008, 138: 2323-2327.
9. Vander Linden IJ, Nguyen U, Heil SG, Franke B, Vloet S, Gellekink H and den Heijer M, et al. Variation and expression of dihydrofolate reductase (DHFR) in relation to spina bifida. Mol Genet Metab 2007, 91: 98-103. (Pubitemid 46550925)
10. Sun SN, Gui YH, Wang YX, Qian LX, Jiang Q, Liu D and Song HY. Effect of dihydrofolate reductase gene knock-down on the expression of heart and neural crest derivatives expressed transcript 2 in zebrafish cardiac development. Chin Med J (Engl) 2007, 120: 1166-1171. (Pubitemid 47189050)
11. Sun S, Gui Y, Wang Y, Qian L, Liu X, Jiang Q and Song H. Effects of methotrexate on the development of heart and vessel in zebrafish. Acta Biochim Biophys Sin 2009, 41: 86-96.
12. Elliott DA, Solloway MJ, Wise N, Biben C, Costa MW, Furtado MB and Lange M, et al. A tyrosine-rich domain within homeodomain transcription factor Nkx2-5 is an essential element in the early cardiac transcriptional regulatory machinery. Development 2006, 133: 1311-1322.
13. Vincentz JW, Barnes RM, Firulli BA, Conway SJ and Firulli AB. Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev Dyn 2008, 237: 3809-3819.
14. Xu H, Morishima M, Wylie JN, Schwartz RJ, Bruneau BG, Lindsay EA and Baldini A. Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development 2004, 31: 3217-3227. (Pubitemid 39077444)
15. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, Arruda EP and Gertsenstein M, et al. Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 2005, 132: 2463-2474. (Pubitemid 40872814)
16. Goddeeris MM, Schwartz R, Klingensmith J and Meyers EN. Independent requirements for Hedgehog signaling by both the anterior heart field and neural crest cells for outflow tract development. Development 2007, 134: 1593-1604. (Pubitemid 46746311)
17. Kimmel CB, Ballard WW, Kimmel SR, Ullmann B and Schilling TF. Stages of embryonic development of the zebrafish. Dev Dyn 1995, 203: 253-310.
18. Wang YX, Qian LX, Yu Z, Jiang Q, Dong YX, Liu XF and Yang XY, et al. Requirements of myocyte-specific enhancer factor 2A in zebrafish cardiac contractility. FEBS Lett 2005, 79: 4843-4850. (Pubitemid 41218673)
19. Berdougo E, Coleman H, Lee DH, Stainier DY and Yelon D. Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 2003, 130: 6121-6129. (Pubitemid 38008813)
20. Benson DW, Silberbach GM, Kavanaugh-McHugh A, Cottrill C, Zhang Y, Riggs S and Smalls O, et al. Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. J Clin Invest 1999, 104: 1567-1573. (Pubitemid 30002368)
21. Tanaka M, Chen Z, Bartunkova S, Yamasaki N and Izumo S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development 1999, 126: 1269-1280. (Pubitemid 29182122)
22. Akazawa H and Komuro I. Cardiac transcription factor Csx/Nkx2-5: its role in cardiac development and diseases. Pharmacol Ther 2005, 107: 252-268. (Pubitemid 40910044)
23. Liu ZP, Nakagawa O, Nakagawa M, Yanagisawa H, Passier R, Richardson JA and Srivastava D, et al. CHAMP, a novel cardiac-specific helicase regulated by MEF2C. Dev Biol 2001, 234: 497-509. (Pubitemid 32552674)
24. Kelly RG and Papaioannou VE. Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene. Dev Dyn 2007, 236: 821-828. (Pubitemid 46449193)
25. Morishima M, Yanagisawa H, Yanagisawa M and Baldini A. Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis. Dev Dyn 2003, 228: 95-104. (Pubitemid 37064847)
26. Nowotschin S, Liao J, Gage PJ, Epstein JA, Campione M and Morrow BE. Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development 2006, 133: 1565-1573. (Pubitemid 43732969)
27. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, Solloway MJ and McCulley DJ, et al. Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 2005, 132: 2451-2462. (Pubitemid 40872813)
28. Stennard FA, Costa MW, Elliott DA, Rankin S, Haast SJ, Lai D and McDonald LP, et al. Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart. Dev Biol 2003, 262: 206-224. (Pubitemid 37194503)
29. Washington Smoak I, Byrd NA, Abu-Issa R, Goddeeris MM, Anderson R, Morris J and Yamamura K, et al. Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. Dev Biol 2005, 283: 357-372. (Pubitemid 40977955)
30. Zhang XM, Ramalho-Santos M and McMahon AP. Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R asymmetry by the mouse node. Cell 2001, 105: 781-792. (Pubitemid 32635107)
31. Schilling TF, Concordet JP and Ingham PW. Regulation of left-right asymmetries in the zebrafish by Shh and BMP4. Dev Biol 1999, 210: 277-287. (Pubitemid 29283004)