Neuroprotective Effects of (−)-Epigallocatechin-3-Gallate Against Focal Cerebral Ischemia/Reperfusion Injury in Rats Through Attenuation of Inflammation

Neurochemical Research

Volumn 40, Issue 8, 2015, Pages 1691-1698

  Zhang, FengJin ^a,b   Li, Na ^a   Jiang, LinLan ^b   Chen, LongHao ^b   Huang, MuTu ^b  

^a SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

Author keywords

( ) Epigallocatechin 3 gallate; Cerebral ischemia reperfusion; Inflammation; Nuclear factor kappa B p65

Indexed keywords

CYCLOOXYGENASE 2; EPIGALLOCATECHIN GALLATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; TRANSCRIPTION FACTOR RELA; TRIPHENYLTETRAZOLIUM; TUMOR NECROSIS FACTOR ALPHA; AUTACOID; CATECHIN; NEUROPROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPHARMACOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; SPRAGUE DAWLEY RAT; UPREGULATION; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; INFLAMMATION; METABOLISM; TREATMENT OUTCOME;

RATTUS;

ANIMALS; BRAIN ISCHEMIA; CATECHIN; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; NEUROPROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 84939260210     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-015-1647-5     Document Type: Article

References (46)

1. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, Moran AE, Sacco RL, Anderson L, Truelsen T, O’Donnell M, Venketasubramanian N, Barker-Collo S, Lawes CMM, Wang WZ, Shinohara Y, Witt E, Ezzati M, Naghavi M, Murray C, Global Burden Dis Injuries Risk F, Grp GBDSE (2014) Global and regional burden of stroke during 1990–2010: findings from the global burden of disease study 2010. Lancet 383:245–255
2. Iadecola C, Anrather J (2011) The immunology of stroke: from mechanisms to translation. Nat Med 17:796–808
3. Magnus T, Wiendl H, Kleinschnitz C (2012) Immune mechanisms of stroke. Curr Opin Neurol 25:334–340
4. Emsley HCA, Smith CJ, Tyrrell PJ, Hopkins SJ (2008) Inflammation in acute ischemic stroke and its relevance to stroke critical care. Neurocrit Care 9:125–138
5. Gu J-H, Ge J-B, Li M, Wu F, Zhang W, Qin Z-H (2012) Inhibition of NF-kappa B activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury. Eur J Pharm Sci 47:652–660
6. Kraft P, Schwarz T, Goeb E, Heydenreich N, Brede M, Meuth SG, Kleinschnitz C (2013) The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis. Exp Neurol 247:80–90
7. Kleinig TJ, Vink R (2009) Suppression of inflammation in ischemic and hemorrhagic stroke: therapeutic options. Curr Opin Neurol 22:294–301
8. Wang Q, Tang XN, Yenari MA (2007) The inflammatory response in stroke. J Neuroimmunol 184:53–68
9. Herges K, Millward JM, Hentschel N, Infante-Duarte C, Aktas O, Zipp F (2011) Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-Gallate in neuroinflammation. Plos One 6(10):e25456
10. Deng F, Li R, Yang Y, Zhou D, Wang Q, Xu J (2011) Neuroprotective effect of epigallocatechin-3-gallate on hemisection-induced spinal cord injury in rats. Neural Regen Res 6:405–411
11. Mandel SA, Avramovich-Tirosh Y, Reznichenko L, Zheng HL, Weinreb O, Amit T, Youdim MBH (2005) Multifunctional activities of green tea catechins in neuroprotection—modulation of cell survival genes, iron-dependent oxidative stress and PKC signaling pathway. Neurosignals 14:46–60
12. Aktas O, Prozorovski T, Smorodchenko A, Savaskan NE, Lauster R, Kloetzel PM, Infante-Duarte C, Brocke S, Zipp F (2004) Green tea epigallocatechin-3-gallate mediates T cellular NF-kappa B inhibition and exerts neuroprotection in autoimmune encephalomyelitis. J Immunol 173:5794–5800
13. Lee SY, Kim CY, Lee JJ, Jung JG, Lee SR (2003) Effects of delayed administration of (−)-epigallocatechin gallate, a green tea polyphenol on the changes in polyamine levels and neuronal damage after transient forebrain ischemia in gerbils. Brain Res Bull 61:399–406
14. Lee H, Bae JH, Lee SR (2004) Protective effect of green tea polyphenol EGCG against neuronal damage and brain edema after unilateral cerebral ischemia in gerbils. J Neurosci Res 77:892–900
15. Choi YB, Kim YI, Lee KS, Kim BS, Kim DJ (2004) Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats. Brain Res 1019:47–54
16. Wu KJ, Hsieh MT, Wu CR, Wood WG, Chen YF (2012) Green tea extract ameliorates learning and memory deficits in Ischemic rats via Its active component polyphenol epigallocatechin-3-gallate by modulation of oxidative stress and neuroinflammation. Evid based complement altern med 2012:106–163
17. Sutherland BA, Rahman RMA, Appleton I (2006) Mechanisms of action of green tea catechins, with a focus on ischemia-induced neurodegeneration. J Nutr Biochem 17:291–306
18. Mao XX, Yin W, Liu MF, Ye MZ, Liu PQ, Liu JX, Lian QS, Xu SW, Pi RB (2011) Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats. Brain Res 1385:275–280
19. Li Q, Zhang T, Wang J, Zhang Z, Zhai Y, Yang G-Y, Sun X (2014) Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke. Biochem Biophys Res Commun 444:182–188
20. Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(−Delta Delta C) method. Methods 25:402–408
21. Wang L, Lu Y, Zhang X, Zhang Y, Jiang D, Dong X, Deng S, Yang L, Guan Y, Zhu L, Zhou Y, Zhang X, Li H (2013) Mindin is a critical mediator of ischemic brain injury in an experimental stroke model. Exp Neurol 247:506–516
22. Jin R, Liu L, Zhang S, Nanda A, Li G (2013) Role of inflammation and its mediators in acute ischemic stroke. J Cardiovasc Transl Res 6:834–851
23. Buttini M, Appel K, Sauter A, Gebicke-Haerter PJ, Boddeke HW (1996) Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat. Neuroscience 71:1–16
24. Intiso D, Zarrelli MM, Lagioia G, Di Rienzo F, De Ambrosio CC, Simone P, Tonali P, Cioffi RP (2004) Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke patients. Neurol Sci 24:390–396
25. Zaremba J, Losy J (2001) Early TNF-alpha levels correlate with ischaemic stroke severity. Acta Neurol Scand 104:288–295
26. Hosomi N, Ban CR, Naya T, Takahashi T, Guo P, Song XYR, Kohno M (2005) Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia. J Cereb Blood Flow Metab 25:959–967
27. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, Lysko PG, Feuerstein GZ (1997) Tumor necrosis factor-alpha—a mediator of focal ischemic brain injury. Stroke 28:1233–1244
28. Denes A, Pinteaux E, Rothwell NJ, Allan SM (2011) Interleukin-1 and stroke: biomarker, harbinger of damage, and therapeutic target. Cerebrovasc Dis 32:517–527
29. Kelsen J, Kjaer K, Chen G, Pedersen M, Rohl L, Frokiaer J, Nielsen S, Nyengaard JR, Ronn LCB (2006) Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response? J Neuroinflammation 3:31
30. Liu T, Zhang T, Yu H, Shen H, Xia W (2014) Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption. J Neuroinflammation 11:107
31. Domac FM, Somay G, Misirli H, Erenoglu NY (2007) Tumor necrosis factor alpha serum levels and inflammatory response in acute ischemic stroke. Neurosciences 12:25–30
32. Kes VB, Simundic A-M, Nikolac N, Topic E, Demarin V (2008) Pro-inflammatory and anti-inflammatory cytokines in acute ischemic stroke and their relation to early neurological deficit and stroke outcome. Clin Biochem 41:1330–1334
33. Mincheva-Tasheva S, Soler RM (2013) NF-kappa B signaling pathways: role in nervous system physiology and pathology. Neuroscientist 19:175–194
34. Mincheva-Tasheva S, Soler RM (2013) NF-κB signaling pathways role in nervous system physiology and pathology. Neuroscientist 19:175–194
35. Kaltschmidt B, Kaltschmidt C, Hofmann TG, Hehner SP, Droge W, Schmitz ML (2000) The pro- or anti-apoptotic function of NF-kappa B is determined by the nature of the apoptotic stimulus. Eur J Biochem 267:3828–3835
36. Kaltschmidt B, Heinrich M, Kaltschmidt C (2002) Stimulus-dependent activation of NF-kappa B specifies apoptosis or neuroprotection in cerebellar granule cells. Neuromol Med 2:299–309
37. Pizzi M, Goffi F, Boroni F, Benarese M, Perkins SE, Liou HC, Spano P (2002) Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1 beta. J Biol Chem 277:20717–20723
38. Jana M, Dasgupta S, Liu X, Pahan K (2002) Regulation of tumor necrosis factor-α expression by CD40 ligation in BV-2 microglial cells. J Neurochem 80:197–206
39. Nakajima K, Matsushita Y, Tohyama Y, Kohsaka S, Kurihara T (2006) Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFκB) inhibitor in rat microglia. Neurosci Lett 401:199–202
40. Bhat NR, Feinstein DL, Shen Q, Bhat AN (2002) p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells roles of nuclear factors, nuclear factor κB, cAMP response element-binding protein, CCAAT/enhance-binding protein-β, and activating transcription factor-2. J Biol Chem 277:29584–29592
41. Dai Y-Q, Jin D-Z, Zhu X-Z, Lei D-L (2006) Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes. Neurosci Res 55:154–160
42. Nurmi A, Lindsberg PJ, Koistinaho M, Zhang W, Juettler E, Karjalainen-Lindsberg ML, Weih F, Frank N, Schwaninger M, Koistinaho J (2004) Nuclear factor-kappa B contributes to infarction after permanent focal ischemia. Stroke 35:987–991
43. Schwaninger M, Inta I, Herrmann O (2006) NF-kappa B signalling in cerebral ischaemia. Biochem Soc Trans 34:1291–1294
44. Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M (1999) NF-kappa B is activated and promotes cell death in focal cerebral ischemia. Nat Med 5:554–559
45. Ma M, Uekawa K, Hasegawa Y, Nakagawa T, Katayama T, Sueta D, Toyama K, Kataoka K, Koibuchi N, J-i Kuratsu, Kim-Mitsuyama S (2013) Pretreatment with rosuvastatin protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress and inflammation. Brain Res 1519:87–94
46. Duckworth EAM, Butler T, Collier L, Collier S, Pennypacker KR (2006) NF-kappa B protects neurons from ischemic injury after middle cerebral artery occlusion in mice. Brain Res 1088:167–175