Neuroprotective effect of epigallocatechin-3-gallate on hemisection-induced spinal cord injury in rats

Neural Regeneration Research

Volumn 6, Issue 6, 2011, Pages 405-411

  Deng, Fengjun ^a   Li, Rubing ^b   Yang, Yingbao ^c   Zhou, Dan ^d   Wang, Qian ^c   Xu, Jiangping ^c  

^a Yiyang Medical College   (China)

^b GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d Laboratory of Surgery Pingxiang Health School   (China)

Author keywords

Apoptosis; Epigallocatechin 3 gallate spinal cord injury; Neuroprotective effect; Oxidative stress; inflammation

Indexed keywords

EPIGALLOCATECHIN GALLATE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MALONALDEHYDE; METHYLPREDNISOLONE SODIUM SUCCINATE; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL ULTRASTRUCTURE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; FEMALE; GENE EXPRESSION; INFLAMMATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; SPINAL CORD HEMISECTION; SPINAL CORD INJURY;

EID: 79952463627     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Yazihan N, Uzuner K, Salman B, et al. Erythropoietin improves oxidative stress following spinal cord trauma in rats. Injury. 2008;39(12):1408-1413.
2. Bao F, John SM, Chen Y, et al. The tripeptide phenylalanine-(D) glutamate-(D) glycine modulates leukocyte infiltration and oxidative damage in rat injured spinal cord. Neuroscience. 2006;140(3):1011-1022.
3. Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third national acute spinal cord injury randomized controlled trial. J Neurosurg. 1998;89(5): 699-706.
4. Qian T, Guo X, Levi AD, et al. Prednisolone may cause myopathy in acute spinal cord injury patients. Spinal Cord. 2005;43(4): 199-203.
5. Taoka Y, Okajima K. Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea. Prog Neurobiol. 1998;56 (3):341-358.
6. Guertin PA. Monoaminergic and catecholaminergic activation of the central pattern generator for locomotion following spinal cord injury. Neural Regen Res. 2009;4 (10):796-800.
7. Sharma HS, Gordh T, Wiklund L, et al. Spinal cord injury induced heat shock protein expression is reduced by an antioxidant compound H-290/51. An experimental study using light and electron microscopy in the rat. J Neural Transm. 2006;113 (4):521-536.
8. Yang YB, Piao YJ. Effects of resveratrol on secondary damages after acute spinal cord injury in rats. Acta Pharmacol Sin. 2003;24 (7):703-710.
9. Samantaray S, Sribnick EA, Das A, et al. Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats. J Pineal Res. 2008;44(4):348-357.
10. Jung YD, Ellis LM. Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea. Int J Exp Pathol. 2001;82(6):309-316.
11. Jung SH, Kang KD, Ji D, et al. The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes. Neurochem Int. 2008;53(6-8):325-337.
12. Stuart EC, Scandlyn MJ, Rosengren RJ. Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer. Life Sci. 2006;79(25):2329-2336.
13. Yuan JH, Li YQ, Yang XY. Inhibition of epigallocatechin gallate on orthotopic colon cancer by upregulating the Nrf2-UGT1A signal pathway in nude mice. Pharmacology. 2007;80(4):269-278.
14. Lee S, Suh S, Kim S. Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett. 2000;287(3):191-194.
15. Haque AM, Hashimoto M, Katakura M, et al. Green tea catechins prevent cognitive deficits caused by Abeta1-40 in rats. J Nutr Biochem. 2008;19(9):619-626.
16. Deng FJ, Yang YB, Xu J P, et al. Effect of epigaloctechin-3-gallit (EGCG) on the release of inflammatory cytokines and expression of neurotrophic factors in spinal cord-injuried rats. Zhongguo Shiyan Fangjixue Zazhi. 2010;5(16):164-167.
17. Robins SL, Fehlings MG. Models of experimental spinal cord injury: translational relevance and impact. Drug Discov Today Dis Models. 2008;5(1):5-11.
18. Kontogeorgakos VA, Voulgaris S, Korompilias AV, et al. The efficacy of erythropoietin on acute spinal cord injury: an experimental study on a rat model. Arch Orthop Trauma Surg. 2009;129(2):189-194.
19. Bavetta S, Hamlyn PJ, Burnstock G, et al. The effects of FK506 on dorsal column axons following spinal cord injury in adult rats: neuroprotection and local regeneration. Exp Neurol. 1999;158(2): 382-393.
20. Oruckaptan HH, Ozisik P, Atilla P, et al. Systemic administration of interleukin-10 attenuates early ischemic response following spinal cord ischemia reperfusion injury in rats. J Surg Res. 2009;155(2): 345-356.
21. Koopmans GC, Deumens R, Buss A, et al. Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury. Exp Neurol. 2009;216(2):490-498.
22. Chen D, Nie M, Fan MW, et al. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology. 2008;82(4):264-269.
23. Lucas SM, Rothwell NJ, Gibson RM. The role of inflammation in CNS injury and disease. Br J Pharmacol. 2006;147 Suppl 1: S232-240.
24. Xiao X, Liu J, Hu J, et al. Protective effects of protopine on hydrogen peroxide-induced oxidative injury of PC12 cells via Ca(2+) antagonism and antioxidant mechanisms. Eur J Pharmacol. 2008;591(1-3):21-27.
25. Yang Z, Jie G, Dong F, et al. Radical-scavenging abilities and antioxidant properties of theaflavins and their gallate esters in H2O2-mediated oxidative damage system in the HPF-1 cells. Toxicol In Vitro. 2008;22(5):1250-1256.
26. Siniscalco D, Fuccio C, Giordano C, et al. Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacol Res. 2007;55(2):158-166.
27. Kroemer G. The proto-oncogene bcl-2 and its role in regulating apoptosis. Nat Med. 1997;3(6):614-620.
28. Merry DE, Korsmeyer SJ. Bcl-2 gene family in the nervous system. Annu Rev Neurosci. 1997;20(3):245-267.
29. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog. Bax, that accelerates programmed cell death. Cell. 1993;74(4):609-619.
30. Kim YT, Caldwell JM, Bellamkonda RV. Nanoparticle-mediated local delivery of methylprednisolone after spinal cord injury. Biomaterials. 2009;30(13):2582-2590.
31. Gok B, Sciubba DM, Okutan O, et al. Immunomodulation of acute experimental spinal cord injury with human immunoglobulin G. J Clin Neurosci. 2009;16(4):549-553.
32. Oruckaptan HH, Ozisik P, Atilla P, et al. Systemic administration of interleukin-10 attenuates early ischemic response following spinal cord ischemia reperfusion injury in rats. J Surg Res. 2009;155(2): 345-356.
33. Davies AL, Hayes KC, Dekaban GA, et al. Clinical correlates of elevated serum concentrations of cytokines and autoantibodies in patients with spinal cord injury. Arch Phys Med Rehabil. 2007; 88(11):1384-1393.
34. van Duijnhoven N, Hesse E, Janssen T, et al. Impact of exercise training on oxidative stress in individuals with a spinal cord injury. Eur J Appl Physiol. 2010;109(6):1059-1066.
35. Genovese T, Esposito E, Mazzon E, et al. Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury. J Pharmacol Exp Ther. 2008;