Pretreatment with rosuvastatin protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress and inflammation

Brain Research

Volumn 1519, Issue , 2013, Pages 87-94

  Ma, Mingjie ^a   Uekawa, Ken ^a   Hasegawa, Yu ^a   Nakagawa, Takashi ^a   Katayama, Tetsuji ^a   Sueta, Daisuke ^a   Toyama, Kensuke ^a   Kataoka, Keiichiro ^a   Koibuchi, Nobutaka ^a   Kuratsu, Jun Ichi ^b   Kim Mitsuyama, Shokei ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Inflammation; Ischemic reperfusion injury; Neuronal cell death; Oxidative stress; Rosuvastatin

Indexed keywords

CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; ROSUVASTATIN; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELL ACTIVATION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BRAIN INFARCTION; BRAIN ISCHEMIA; CALCIUM-BINDING PROTEINS; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ECTODYSPLASINS; ENCEPHALITIS; FLUOROBENZENES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MEMBRANE GLYCOPROTEINS; MICROFILAMENT PROTEINS; NADPH OXIDASE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; OXIDATIVE STRESS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SULFONAMIDES; UP-REGULATION;

RATTUS;

EID: 84878753939     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.04.040     Document Type: Article

References (29)

1. C. Baigent, A. Keech, P.M. Kearney, L. Blackwell, G. Buck, C. Pollicino, A. Kirby, T. Sourjina, R. Peto, R. Collins, and R. Simes Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 366 2005 1267 1278
2. P.H. Chan Reactive oxygen radicals in signaling and damage in the ischemic brain J. Cereb. Blood Flow Metab. 21 2001 2 14
3. J. Chen, D. Li, R. Schaefer, and J.L. Mehta Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan Atherosclerosis 184 2006 295 301
4. Z.B. Chen, D.Q. Huang, F.N. Niu, X. Zhang, E.G. Li, and Y. Xu Human urinary kallidinogenase suppresses cerebral inflammation in experimental stroke and downregulates nuclear factor-kappaB J. Cereb. Blood Flow Metab. 30 2010 1356 1365
5. G.R. Drummond, S. Selemidis, K.K. Griendling, and C.G. Sobey Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets Nat. Rev. Drug Discovery 10 2011 453 471
6. J.H. Garcia, K.F. Liu, and K.L. Ho Neuronal necrosis after middle cerebral artery occlusion in Wistar rats progresses at different time intervals in the caudoputamen and the cortex Stroke 26 1995 636 642 discussion 643
7. M. Gelderblom, F. Leypoldt, K. Steinbach, D. Behrens, C.U. Choe, D.A. Siler, T.V. Arumugam, E. Orthey, C. Gerloff, E. Tolosa, and T. Magnus Temporal and spatial dynamics of cerebral immune cell accumulation in stroke Stroke 40 2009 1849 1857
8. N. Grosser, K. Erdmann, A. Hemmerle, G. Berndt, U. Hinkelmann, G. Smith, and H. Schroder Rosuvastatin upregulates the antioxidant defense protein heme oxygenase-1 Biochem. Biophys. Res. Commun. 325 2004 871 876
9. L. Gullestad, T. Ueland, J. Kjekshus, S.H. Nymo, J. Hulthe, P. Muntendam, J.J. McMurray, J. Wikstrand, and P. Aukrust The predictive value of galectin-3 for mortality and cardiovascular events in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) Am. Heart J. 164 2012 878 883
10. Y. Hasegawa, H. Suzuki, T. Sozen, W. Rolland, and J.H. Zhang Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats Stroke 41 2010 368 374
11. H. Hong, J.S. Zeng, D.L. Kreulen, D.I. Kaufman, and A.F. Chen Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke Am. J. Physiol. Heart Circ. Physiol. 291 2006 H2210 H2215
12. R. Jin, G. Yang, and G. Li Inflammatory mechanisms in ischemic stroke: role of inflammatory cells J. Leukoc. Biol. 87 2010 779 789
13. J.E. Jung, G.S. Kim, H. Chen, C.M. Maier, P. Narasimhan, Y.S. Song, K. Niizuma, M. Katsu, N. Okami, H. Yoshioka, H. Sakata, C.E. Goeders, and P.H. Chan Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection Mol. Neurobiol. 41 2010 172 179
14. T. Kahles, and R.P. Brandes NADPH oxidases as therapeutic targets in ischemic stroke Cell Mol. Life Sci. 69 2012 2345 2363
15. T. Kahles, and R.P. Brandes NADPH oxidases as therapeutic targets in ischemic stroke Cell. Mol. Life Sci. 69 2012 2345 2363
16. S. Kim-Mitsuyama, E. Yamamoto, T. Tanaka, Y. Zhan, Y. Izumi, Y. Izumiya, T. Ioroi, H. Wanibuchi, and H. Iwao Critical role of angiotensin II in excess salt-induced brain oxidative stress of stroke-prone spontaneously hypertensive rats Stroke 36 2005 1083 1088
17. C.E. Kosmas, H. Alkhawam, M. El-Hunjul, G. Wagman, M.R. Kahn, K.M. Grady, and T.J. Vittorio Statin-mediated low-density lipoprotein lowering in chronic congestive heart failure Am. J. Med. Sci. 2012
18. U. Laufs, K. Gertz, U. Dirnagl, M. Bohm, G. Nickenig, and M. Endres Rosuvastatin, a new HMG-CoA reductase inhibitor, upregulates endothelial nitric oxide synthase and protects from ischemic stroke in mice Brain Res. 942 2002 23 30
19. M.J. Leach, J.H. Swan, D. Eisenthal, M. Dopson, and M. Nobbs BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage Stroke 24 1993 1063 1067
20. C. Mayer, H.J. Gruber, E.M. Landl, S. Pailer, H. Scharnagl, M. Truschnig-Wilders, and W. Marz Rosuvastatin reduces interleukin-6-induced expression of C-reactive protein in human hepatocytes in a STAT3- and C/EBP-dependent fashion Int. J. Clin. Pharmacol. Ther. 45 2007 319 327
21. F. McTaggart, L. Buckett, R. Davidson, G. Holdgate, A. McCormick, D. Schneck, G. Smith, and M. Warwick Preclinical and clinical pharmacology of Rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Am. J. Cardiol. 87 2001 28B 32B
22. S. Nagotani, T. Hayashi, K. Sato, W. Zhang, K. Deguchi, I. Nagano, M. Shoji, and K. Abe Reduction of cerebral infarction in stroke-prone spontaneously hypertensive rats by statins associated with amelioration of oxidative stress Stroke 36 2005 670 672
23. A. Ose, H. Kusuhara, C. Endo, K. Tohyama, M. Miyajima, S. Kitamura, and Y. Sugiyama Functional characterization of mouse organic anion transporting peptide 1a4 in the uptake and efflux of drugs across the blood-brain barrier Drug Metab. Dispos. 38 2010 168 176
24. A. Saito, C.M. Maier, P. Narasimhan, T. Nishi, Y.S. Song, F. Yu, J. Liu, Y.S. Lee, C. Nito, H. Kamada, R.L. Dodd, L.B. Hsieh, B. Hassid, E.E. Kim, M. Gonzalez, and P.H. Chan Oxidative stress and neuronal death/survival signaling in cerebral ischemia Mol. Neurobiol. 31 2005 105 116
25. R. Schreck, P. Rieber, and P.A. Baeuerle Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1 EMBO J. 10 1991 2247 2258
26. S. Sierra, M.C. Ramos, P. Molina, C. Esteo, J.A. Vazquez, and J.S. Burgos Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death J. Alzheimers Dis. 23 2011 307 318
27. S. Wassmann, U. Laufs, K. Muller, C. Konkol, K. Ahlbory, A.T. Baumer, W. Linz, M. Bohm, and G. Nickenig Cellular antioxidant effects of atorvastatin in vitro and in vivo Arterioscler Thromb. Vasc. Biol. 22 2002 300 305
28. M.A. Yenari, T.M. Kauppinen, and R.A. Swanson Microglial activation in stroke: therapeutic targets Neurotherapeutics 7 2010 378 391
29. A. Zacco, J. Togo, K. Spence, A. Ellis, D. Lloyd, S. Furlong, and T. Piser 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity J. Neurosci. 23 2003 11104 11111