Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

Biochemical and Biophysical Research Communications

Volumn 444, Issue 2, 2014, Pages 182-188

  Li, Qiang ^a,b   Zhang, Ting ^a   Wang, Jixian ^a,b   Zhang, Zhijun ^a   Zhai, Yu ^b   Yang, Guo Yuan ^a,b   Sun, Xiaojiang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Brain; Ischemia; Mitochondria function; Mitophagy; Rapamycin

Indexed keywords

BRAIN; ISCHEMIA; MITOCHONDRIA FUNCTION; MITOPHAGY; RAPAMYCIN;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; BRAIN; BRAIN ISCHEMIA; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL DEGRADATION; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS; STROKE;

EID: 84894560304     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.01.032     Document Type: Article

References (27)

1. N. Mizushima, B. Levine, A.M. Cuervo, and D.J. Klionsky Autophagy fights disease through cellular self-digestion Nature 451 2008 1069 1075
2. K. Niizuma, H. Yoshioka, H. Chen, G.S. Kim, J.E. Jung, M. Katsu, N. Okami, and P.H. Chan Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia Biochim. Biophys. Acta 1802 2010 92 99
3. M.A. Moskowitz, E.H. Lo, and C. Iadecola The science of stroke: mechanisms in search of treatments Neuron 67 2010 181 198
4. M. Christophe, and S. Nicolas Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion Curr. Pharm. Des. 12 2006 739 757
5. G. Ashrafi, and T.L. Schwarz The pathways of mitophagy for quality control and clearance of mitochondria Cell Death Differ. 20 2013 31 42
6. R.J. Youle, and D.P. Narendra Mechanisms of mitophagy Nat. Rev. Mol. Cell Biol. 12 2011 9 14
7. D.A. Kubli, and A.B. Gustafsson Mitochondria and mitophagy: the yin and yang of cell death control Circ. Res. 111 2012 1208 1221
8. C. Huang, A.M. Andres, E.P. Ratliff, G. Hernandez, P. Lee, and R.A. Gottlieb Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1 PLoS ONE 6 2011 e20975
9. A. Hoshino, S. Matoba, E. Iwai-Kanai, H. Nakamura, M. Kimata, M. Nakaoka, M. Katamura, Y. Okawa, M. Ariyoshi, Y. Mita, K. Ikeda, T. Ueyama, M. Okigaki, and H. Matsubara P53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia J. Mol. Cell. Cardiol. 52 2012 175 184
10. S. Erlich, A. Alexandrovich, E. Shohami, and R. Pinkas-Kramarski Rapamycin is a neuroprotective treatment for traumatic brain injury Neurobiol. Dis. 26 2007 86 93
11. C. Malagelada, Z.H. Jin, V. Jackson-Lewis, S. Przedborski, and L.A. Greene Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease J. Neurosci. 30 2010 1166 1175
12. S. Carloni, G. Buonocore, and W. Balduini Protective role of autophagy in neonatal hypoxia-ischemia induced brain injury Neurobiol. Dis. 32 2008 329 339
13. R. Sheng, L.S. Zhang, R. Han, X.Q. Liu, B. Gao, and Z.H. Qin Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning Autophagy 6 2010 482 494
14. F. Yuan, Y. Tang, X. Lin, Y. Xi, Y. Guan, T. Xiao, J. Chen, Z. Zhang, G.Y. Yang, and Y. Wang Optimizing suture middle cerebral artery occlusion model in C57BL/6 mice circumvents posterior communicating artery dysplasia J. Neurotrauma 29 2012 1499 1505
15. Y. Fan, F. Shen, T. Frenzel, W. Zhu, J. Ye, J. Liu, Y. Chen, H. Su, W.L. Young, and G.Y. Yang Endothelial progenitor cell transplantation improves long-term stroke outcome in mice Ann. Neurol. 67 2010 488 497
16. G.Y. Yang, Y.J. Zhao, B.L. Davidson, and A.L. Betz Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury Brain Res. 751 1997 181 188
17. K.P. Loh, S.H. Huang, B.K. Tan, and Y.Z. Zhu Cerebral protection of purified Herba Leonuri extract on middle cerebral artery occluded rats J. Ethnopharmacol. 125 2009 337 343
18. D.J. Klionsky, F.C. Abdalla, H. Abeliovich, R.T. Abraham, A. Acevedo-Arozena, and K. Adeli et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy 8 2012 445 544
19. T.H. Pankiv, T. Clausen, A. Lamark, J.A. Brech, H. Bruun, A. Outzen, G. Overvatn, and T. Bjorkoy Johansen, p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy J. Biol. Chem. 282 2007 24131 24145
20. M. Laplante, and D.M. Sabatini MTOR signaling in growth control and disease Cell 149 2012 274 293
21. K.J. Hughes, and B.K. Kennedy Cell biology. Rapamycin paradox resolved Science 335 2012 1578 1579
22. T. Ma, C.A. Hoeffer, E. Capetillo-Zarate, F. Yu, H. Wong, M.T. Lin, D. Tampellini, E. Klann, R.D. Blitzer, and G.K. Gouras Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease PLoS ONE 5 2010
23. L. Yin, S. Ye, Z. Chen, and Y. Zeng Rapamycin preconditioning attenuates transient focal cerebral ischemia/reperfusion injury in mice Int. J. Neurosci. 122 2012 748 756
24. B. Gabryel, A. Kost, and D. Kasprowska Neuronal autophagy in cerebral ischemia-a potential target for neuroprotective strategies? Pharmacol. Rep. 64 2012 1 15
25. W.X. Ding, H.M. Ni, M. Li, Y. Liao, X. Chen, D.B. Stolz, G.W. Dorn 2nd, and X.M. Yin Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming J. Biol. Chem. 285 2010 27879 27890
26. M.L. Seibenhener, J.R. Babu, T. Geetha, H.C. Wong, N.R. Krishna, and M.W. Wooten Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation Mol. Cell. Biol. 24 2004 8055 8068
27. T.H. Sanderson, C.A. Reynolds, R. Kumar, K. Przyklenk, and M. Huttemann Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation Mol. Neurobiol. 47 2013 9 23