NF-κB protects neurons from ischemic injury after middle cerebral artery occlusion in mice

Brain Research

Volumn 1088, Issue 1, 2006, Pages 167-175

  Duckworth, Edward A M ^a   Butler, Tanya ^a   Collier, Lisa ^a   Collier, Shane ^a   Pennypacker, Keith R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Fluoro Jade; Focal ischemia; MCAO; Mouse; Neuroprotection; NF B

Indexed keywords

BETA GALACTOSIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN P50; FLUORO JADE; ORGANIC COMPOUND;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN NERVE CELL; BRAIN REGION; CONTROLLED STUDY; CORPUS STRIATUM; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE DEGENERATION; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN ENGINEERING; PYRAMIDAL NERVE CELL; STROKE; SURVIVAL; ANIMAL; BRAIN INJURY; C57BL MOUSE; CEREBRAL ARTERY DISEASE; COMPARATIVE STUDY; DIAGNOSTIC IMAGING; HEMISPHERIC DOMINANCE; METABOLISM; METHODOLOGY; MOUSE MUTANT; NERVE CELL; PATHOLOGY; PHYSIOLOGY;

MURINAE; MUS MUSCULUS;

ANIMALS; BETA-GALACTOSIDASE; BRAIN INJURIES; DIAGNOSTIC IMAGING; FUNCTIONAL LATERALITY; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEURONS; NF-KAPPA B; ORGANIC CHEMICALS;

EID: 33646558596     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2006.02.103     Document Type: Article

References (37)

1. Arystarkhova E., Donnet C., Asinovski N.K., and Sweadner K.J. Differential regulation of renal Na,K-ATPase by splice variants of the gamma subunit. J. Biol. Chem. 277 (2002) 10162-10172
2. Baeuerle P.A., and Baltimore D. NF-kappa B: ten years after. Cell 87 (1996) 13-20
3. Beg A.A., Sha W.C., Bronson R.T., Ghosh S., and Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature 376 (1995) 167-170
4. Blondeau N., Widmann C., Lazdunski M., and Heurteaux C. Activation of the nuclear factor-κB is a key event in brain tolerance. J. Neurosci. 21 (2001) 4668-4677
5. Butler T.L., Kassed C.A., Sanberg P.R., Willing A.E., and Pennypacker K.R. Neurodegeneration in the rat hippocampus and striatum after middle cerebral artery occlusion. Brain Res. 929 (2002) 252-260
6. Chen L.-W., Egan L., Li Z.-W., Greten F.R., Kagnoff M.F., and Karin M. The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat. Med. 9 (2003) 575-581
7. Clemens J., Stephenson D., Yin T., Smalstig E., Panetta J., and Little S. Drug induced neuroprotection from global ischemia is associated with prevention of persistent not transient activation of NF-κB in rats. Stroke 29 (1998) 677-682
8. Culmsee C., Siewe J., Junker V., Retiounskaia M., Schwarz S., Camandola S., El-Metainy S., et al. Reciprocal Inhibition of p53 and nuclear factor-κB transcriptional activities determines cell survival or death in neurons. J. Neurosci. 23 (2003) 8586-8595
9. Duckworth E.A., Butler T.L., De Mesquita D., Collier S.N., Collier L., and Pennypacker K.R. Temporary focal ischemia in the mouse: technical aspects and patterns of Fluoro-Jade evident neurodegeneration. Brain Res. 1042 (2005) 29-36
10. Fisher M., and Brott T. Emerging therapies for acute ischemic stroke: new therapies on trial. Stroke 34 (2003) 359-361
11. Fisher M., and Schaebitz W. An overview of acute stroke therapy: past, present, and future. Arch. Int. Med. 160 (2000) 3196-3206
12. Foehr E.D., Lin X., O'Mahony A., Geleziunas R., Bradshaw R.A., and Greene W.C. NF-κB signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J. Neurosci. 20 (2000) 7556-7563
13. Hacke W., Brott T., Caplan L., Meier D., Fieschi C., von Kummer R., et al. Thrombolysis in acute ischemic stroke: controlled trials and clinical experience. Neurology 53 (1999) S3-S14 (suppl)
14. Hill W.D., Hess D.C., Carroll J.E., Wakade C.G., Howard E.F., Chen Q., Cheng C., et al. The NF-κB inhibitor diethyldithiocarbamate (DDTC) increases brain cell death in a transient middle cerebral artery occlusion model of ischemia. Brain Res. Bull. 55 (2001) 375-386
15. Hu B.R., Martone M.E., Jones Y.Z., and Liu C.L. Protein aggregation after transient cerebral ischemia. J. Neurosci. 20 (2000) 3191-3199
16. Kassed C.A., Willing A.E., Garbuzova-Davis S., Sanberg P.R., and Pennypacker K.R. Lack of NF-κB exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning. Exp. Neurol. 176 (2002) 277-288
17. Kassed C.A., Butler T.L., Navidomskis M.T., Gordon M.N., Morgan D., and Pennypacker K.R. Mice expressing human presenilin-1 exhibit decreased activation of NF-κB p50 in hippocampal neurons after injury. Mol. Brain Res. 110 (2003) 152-157
18. Kassed C.A., Butler T.L., Patton G.W., Demesquita D.D., Navidomskis M.T., Memet S., Israel A., and Pennypacker K.R. Injury-induced NF-kappaB activation in the hippocampus: implications for neuronal survival. FASEB J. 18 (2004) 723-724
19. Lee J.I., and Burckart G.J. Nuclear factor kappa B: important transcription factor and therapeutic target. J. Clin. Pharmacol. 38 (1998) 981-993
20. Li X., and Stark G.R. NF-κB-dependent signaling pathways. Exp. Hematol. 30 (2002) 285-296
21. Lipton S.A. Janus faces of NF-kappa B: neurodestruction versus neuroprotection. Nat. Med. 3 (1997) 20-22
22. Liu C.L., Ge P., Zhang F., and Hu B.R. Co-translational protein aggregation after transient cerebral ischemia. Neuroscience 134 (2005) 1273-1284
23. Lovblad K.-O., El-Koussy M., Oswald H., Baird A.E., Schroth G., and Mattle H. Magnetic resonance imaging of the ischaemic penumbra. Swiss Med. Wkly. 133 (2003) 551-559
24. Maggirwar S.B., Sarmiere P.D., Dewhurst S., and Freeman R.S. Nerve growth factor-dependent activation of NF-κB contributes to survival of sympathetic neurons. J. Neurosci. 18 (1998) 10356-10365
25. Mattson M.P., and Camandola S. NF-κB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107 (2001) 247-254
26. Mattson M.P., Culmsee C., and Yu Z.F. Apoptotic and antiapoptotic mechanisms in stroke. Cell. Tissue Res. 301 (2000) 173-187
27. Nonaka M., Chen X.H., Pierce J.E., Leoni M.J., McIntosh T.K., Wolf J.A., and Smith D.H. Prolonged activation of NF-kappaB following traumatic brain injury in rats. J. Neurotrauma 16 (1999) 1023-1034
28. Nurmi A., Lindsberg P., Koistinaho M., Zhang W., Juettler E., Karjalainen-Lindsberg M., Weih F., et al. Nuclear factor-κB contributes to infarction after permanent focal ischemia. Stroke 35 (2004) 987-991
29. Pennypacker K.R., Kassed C.A., Eidizdeh S., Saporta A., Sanberg P.R., and Willing A.E. NF-κB p50 is increased in neurons surviving hippocampal injury. Exp. Neurol. 172 (2001) 307-319
30. Rong Y., and Baudry M. Seizure activity results in a rapid induction of nuclear factor-kappa B in adult but not juvenile rat limbic structures. J. Neurochem. 67 (1996) 662-668
31. Schmid R.M., Perkins N.D., Duckett C.S., Andrews P.C., and Nabel G.J. Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65. Nature 22 (1991) 733-736
32. Schmidt-Ulrich R., Memet S., Lillienbaum A., Feullard J., Raphail M., and Israël A. NF-κB activity in transgenic mice: developmental regulation and tissue specificity. Development 122 (1996) 2117-2128
33. Schmued L.C., Albertson C., and Slikker W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res. 751 (1997) 37-46
34. Schneider A., Martin-Villalba A., Weih F., Vogel J., Wirth T., and Schwaninger M. NF-κB is activated and promotes cell death in focal cerebral ischemia. Nat. Med. 5 (1999) 554-559
35. Sen R., and Baltimore D. Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell 47 (1986) 921-928
36. Wetzel R.K., Pascoa J.L., and Arystarkhova E. Stress-induced expression of the gamma subunit (FXYD2) modulates Na,K-ATPase activity and cell growth. J. Biol. Chem. 279 (2004) 41750-41757
37. Yu Z.F., Zhou D., Bruce-Keller A.J., Kindy B., and Mattson M.P. Lack of the p50 subunit of nuclear factor-κB increases the vulnerability of hippocampal neurons to excitotoxic injury. J. Neurosci. 19 (1999) 8856-8865