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Volumn 6, Issue 23, 2015, Pages 19393-19404

The anticancer immune response of anti-PD-1/PD-L1 and the genetic determinants of response to anti-PD-1/PD-L1 antibodies in cancer patients

Author keywords

Cancer; Checkpoint inhibitor; Immunotherapy; PD 1; PD L1

Indexed keywords

B RAF KINASE; DABRAFENIB; DACARBAZINE; DURVALUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; IPILIMUMAB; MESSENGER RNA; MONOCLONAL ANTIBODY; MPDL 3280A; NIVOLUMAB; PEMBROLIZUMAB; PIDILIZUMAB; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH 1 RECEPTOR; RITUXIMAB; TRAMETINIB; VEMURAFENIB;

EID: 84939218794     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.5107     Document Type: Article
Times cited : (59)

References (96)
  • 1
    • 84928901590 scopus 로고    scopus 로고
    • Cancer immunology and immunotherapy. Realizing the promise. Introduction
    • Mueller KL. Cancer immunology and immunotherapy. Realizing the promise. Introduction. Science. 2015; 348:54-55.
    • (2015) Science. , vol.348 , pp. 54-55
    • Mueller, K.L.1
  • 2
    • 84890829415 scopus 로고    scopus 로고
    • Cancer immunotherapy
    • McNutt M. Cancer immunotherapy. Science. 2013; 342:1417.
    • (2013) Science. , vol.342 , pp. 1417
    • McNutt, M.1
  • 4
    • 0031685190 scopus 로고    scopus 로고
    • Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses
    • Nishimura H, Minato N, Nakano T and Honjo T. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. International immunology. 1998; 10:1563-1572.
    • (1998) International immunology. , vol.10 , pp. 1563-1572
    • Nishimura, H.1    Minato, N.2    Nakano, T.3    Honjo, T.4
  • 5
    • 84887996393 scopus 로고    scopus 로고
    • PD-1 targeting in cancer immunotherapy
    • Ferris R. PD-1 targeting in cancer immunotherapy. Cancer. 2013; 119:E1-3.
    • (2013) Cancer. , vol.119 , pp. E1-E3
    • Ferris, R.1
  • 9
    • 0037152153 scopus 로고    scopus 로고
    • Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
    • Ishida M, Iwai Y, Tanaka Y, Okazaki T, Freeman GJ, Minato N and Honjo T. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunology letters. 2002; 84:57-62.
    • (2002) Immunology letters. , vol.84 , pp. 57-62
    • Ishida, M.1    Iwai, Y.2    Tanaka, Y.3    Okazaki, T.4    Freeman, G.J.5    Minato, N.6    Honjo, T.7
  • 13
    • 77957664158 scopus 로고    scopus 로고
    • Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
    • Zhang Y, Huang S, Gong D, Qin Y and Shen Q. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer. Cellular&molecular immunology. 2010; 7:389-395.
    • (2010) Cellular&molecular immunology. , vol.7 , pp. 389-395
    • Zhang, Y.1    Huang, S.2    Gong, D.3    Qin, Y.4    Shen, Q.5
  • 14
    • 84924577386 scopus 로고    scopus 로고
    • Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers
    • Kim MY, Koh J, Kim S, Go H, Jeon YK and Chung DH. Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. Lung cancer. 2015; 88:24-33.
    • (2015) Lung cancer. , vol.88 , pp. 24-33
    • Kim, M.Y.1    Koh, J.2    Kim, S.3    Go, H.4    Jeon, Y.K.5    Chung, D.H.6
  • 21
    • 84924272311 scopus 로고    scopus 로고
    • PD-1 pathway inhibitors: the next generation of immunotherapy for advanced melanoma
    • Luke JJ and Ott PA. PD-1 pathway inhibitors: the next generation of immunotherapy for advanced melanoma. Oncotarget. 2015; 6:3479-3492.
    • (2015) Oncotarget. , vol.6 , pp. 3479-3492
    • Luke, J.J.1    Ott, P.A.2
  • 23
    • 34547794178 scopus 로고    scopus 로고
    • PD-1 and PD-1 ligands: from discovery to clinical application
    • Okazaki T and Honjo T. PD-1 and PD-1 ligands: from discovery to clinical application. International immunology. 2007; 19:813-824.
    • (2007) International immunology. , vol.19 , pp. 813-824
    • Okazaki, T.1    Honjo, T.2
  • 31
    • 84863988980 scopus 로고    scopus 로고
    • Overexpression of programmed death ligand 1 in dendritic cells inhibits allogeneic lymphocyte activation in mice
    • Li W, Wang X, Chen R, Zhu H, Chen G and Sun X. Overexpression of programmed death ligand 1 in dendritic cells inhibits allogeneic lymphocyte activation in mice. The Journal of surgical research. 2012; 176:e79-87.
    • (2012) The Journal of surgical research. , vol.176 , pp. e79-e87
    • Li, W.1    Wang, X.2    Chen, R.3    Zhu, H.4    Chen, G.5    Sun, X.6
  • 35
    • 84912111808 scopus 로고    scopus 로고
    • The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
    • Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, Cui G, Li MO and Kaech SM. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity. 2014; 41:802-814.
    • (2014) Immunity. , vol.41 , pp. 802-814
    • Staron, M.M.1    Gray, S.M.2    Marshall, H.D.3    Parish, I.A.4    Chen, J.H.5    Perry, C.J.6    Cui, G.7    Li, M.O.8    Kaech, S.M.9
  • 37
    • 56049111621 scopus 로고    scopus 로고
    • Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages
    • Cho HY, Lee SW, Seo SK, Choi IW, Choi I and Lee SW. Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages. Biochimica et biophysica acta. 2008; 1779:811-819.
    • (2008) Biochimica et biophysica acta. , vol.1779 , pp. 811-819
    • Cho, H.Y.1    Lee, S.W.2    Seo, S.K.3    Choi, I.W.4    Choi, I.5    Lee, S.W.6
  • 40
    • 84863089861 scopus 로고    scopus 로고
    • Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation
    • Patsoukis N, Brown J, Petkova V, Liu F, Li L and Boussiotis VA. Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation. Science signaling. 2012; 5:ra46.
    • (2012) Science signaling , vol.5
    • Patsoukis, N.1    Brown, J.2    Petkova, V.3    Liu, F.4    Li, L.5    Boussiotis, V.A.6
  • 43
    • 58149191881 scopus 로고    scopus 로고
    • The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands
    • Kinter AL, Godbout EJ, McNally JP, Sereti I, Roby GA, O'Shea MA and Fauci AS. The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands. Journal of immunology. 2008; 181:6738-6746.
    • (2008) Journal of immunology. , vol.181 , pp. 6738-6746
    • Kinter, A.L.1    Godbout, E.J.2    McNally, J.P.3    Sereti, I.4    Roby, G.A.5    O'Shea, M.A.6    Fauci, A.S.7
  • 44
    • 78649753884 scopus 로고    scopus 로고
    • PD-L1( hi) retinal pigment epithelium (RPE) cells elicited by inflammatory cytokines induce regulatory activity in uveitogenic T cells
    • Ke Y, Sun D, Jiang G, Kaplan HJ and Shao H. PD-L1( hi) retinal pigment epithelium (RPE) cells elicited by inflammatory cytokines induce regulatory activity in uveitogenic T cells. Journal of leukocyte biology. 2010; 88:1241-1249.
    • (2010) Journal of leukocyte biology. , vol.88 , pp. 1241-1249
    • Ke, Y.1    Sun, D.2    Jiang, G.3    Kaplan, H.J.4    Shao, H.5
  • 48
    • 84862111685 scopus 로고    scopus 로고
    • IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells
    • Matta BM, Raimondi G, Rosborough BR, Sumpter TL and Thomson AW. IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells. Journal of immunology. 2012; 188:5227-5237.
    • (2012) Journal of immunology. , vol.188 , pp. 5227-5237
    • Matta, B.M.1    Raimondi, G.2    Rosborough, B.R.3    Sumpter, T.L.4    Thomson, A.W.5
  • 49
    • 75049083688 scopus 로고    scopus 로고
    • Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter
    • Kaku H and Rothstein TL. Octamer binding protein 2 (Oct2) regulates PD-L2 gene expression in B-1 cells through lineage-specific activity of a unique, intronic promoter. Genes and immunity. 2010; 11:55-66.
    • (2010) Genes and immunity. , vol.11 , pp. 55-66
    • Kaku, H.1    Rothstein, T.L.2
  • 50
    • 33846503502 scopus 로고    scopus 로고
    • B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death
    • Radhakrishnan S, Nguyen LT, Ciric B, Van Keulen VP and Pease LR. B7-DC/PD-L2 cross-linking induces NF-kappaB-dependent protection of dendritic cells from cell death. Journal of immunology. 2007; 178:1426-1432.
    • (2007) Journal of immunology. , vol.178 , pp. 1426-1432
    • Radhakrishnan, S.1    Nguyen, L.T.2    Ciric, B.3    Van Keulen, V.P.4    Pease, L.R.5
  • 52
    • 84886943680 scopus 로고    scopus 로고
    • Endogenous tumor-reactive CD8 T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth
    • Liu X, Gibbons RM, Harrington SM, Krco CJ, Markovic SN, Kwon ED and Dong H. Endogenous tumor-reactive CD8 T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth. Oncoimmunology. 2013; 2:e23972.
    • (2013) Oncoimmunology. , vol.2
    • Liu, X.1    Gibbons, R.M.2    Harrington, S.M.3    Krco, C.J.4    Markovic, S.N.5    Kwon, E.D.6    Dong, H.7
  • 54
    • 84879104519 scopus 로고    scopus 로고
    • Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
    • Duraiswamy J, Kaluza KM, Freeman GJ and Coukos G. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer research. 2013; 73:3591-3603.
    • (2013) Cancer research. , vol.73 , pp. 3591-3603
    • Duraiswamy, J.1    Kaluza, K.M.2    Freeman, G.J.3    Coukos, G.4
  • 56
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE and Rosenberg SA. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood. 2009; 114:1537-1544.
    • (2009) Blood. , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6    Rosenberg, S.A.7
  • 57
  • 60
    • 84929643177 scopus 로고    scopus 로고
    • Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma
    • Feng Y, Shen J, Gao Y, Liao Y, Cote G, Choy E, Chebib I, Mankin H, Hornicek F and Duan Z. Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget. 2015; 6:11139-11149.
    • (2015) Oncotarget. , vol.6 , pp. 11139-11149
    • Feng, Y.1    Shen, J.2    Gao, Y.3    Liao, Y.4    Cote, G.5    Choy, E.6    Chebib, I.7    Mankin, H.8    Hornicek, F.9    Duan, Z.10
  • 65
    • 84904751102 scopus 로고    scopus 로고
    • Targeting the PD-1 pathway: a promising future for the treatment of melanoma
    • Mamalis A, Garcha M and Jagdeo J. Targeting the PD-1 pathway: a promising future for the treatment of melanoma. Archives of dermatological research. 2014; 306:511-519.
    • (2014) Archives of dermatological research. , vol.306 , pp. 511-519
    • Mamalis, A.1    Garcha, M.2    Jagdeo, J.3
  • 78
    • 26444468911 scopus 로고    scopus 로고
    • BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice
    • Hardy B, Morgenstern S, Raiter A, Rodionov G, Fadaeev L and Niv Y. BAT monoclonal antibody immunotherapy of human metastatic colorectal carcinoma in mice. Cancer letters. 2005; 229:217-222.
    • (2005) Cancer letters. , vol.229 , pp. 217-222
    • Hardy, B.1    Morgenstern, S.2    Raiter, A.3    Rodionov, G.4    Fadaeev, L.5    Niv, Y.6
  • 83
    • 84939221583 scopus 로고    scopus 로고
    • A new addition to the PD-1 checkpoint inhibitors for non-small cell lung cancer-the anti-PDL1 antibody-MEDI4736
    • Lee SM and Chow LQ. A new addition to the PD-1 checkpoint inhibitors for non-small cell lung cancer-the anti-PDL1 antibody-MEDI4736. Translational lung cancer research. 2014; 3:408-410.
    • (2014) Translational lung cancer research. , vol.3 , pp. 408-410
    • Lee, S.M.1    Chow, L.Q.2
  • 84
    • 84931054440 scopus 로고    scopus 로고
    • The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs
    • Tang Y, Fang W, Zhang Y, Hong S, Kang S, Yan Y, Chen N, Zhan J, He X, Qin T, Li G, Tang W, Peng P and Zhang L. The association between PD-L1 and EGFR status and the prognostic value of PD-L1 in advanced non-small cell lung cancer patients treated with EGFR-TKIs. Oncotarget. 2015; 6:14209-14219.
    • (2015) Oncotarget. , vol.6 , pp. 14209-14219
    • Tang, Y.1    Fang, W.2    Zhang, Y.3    Hong, S.4    Kang, S.5    Yan, Y.6    Chen, N.7    Zhan, J.8    He, X.9    Qin, T.10    Li, G.11    Tang, W.12    Peng, P.13    Zhang, L.14
  • 88
    • 84890888514 scopus 로고    scopus 로고
    • Targeting the PD1/PD-L1 axis in melanoma: biological rationale, clinical challenges and opportunities
    • Merelli B, Massi D, Cattaneo L and Mandala M. Targeting the PD1/PD-L1 axis in melanoma: biological rationale, clinical challenges and opportunities. Critical reviews in oncology/hematology. 2014; 89:140-165.
    • (2014) Critical reviews in oncology/hematology. , vol.89 , pp. 140-165
    • Merelli, B.1    Massi, D.2    Cattaneo, L.3    Mandala, M.4
  • 91
    • 84897404380 scopus 로고    scopus 로고
    • Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes
    • Yang CY, Lin MW, Chang YL, Wu CT and Yang PC. Programmed cell death-ligand 1 expression in surgically resected stage I pulmonary adenocarcinoma and its correlation with driver mutations and clinical outcomes. European journal of cancer. 2014; 50:1361-1369.
    • (2014) European journal of cancer. , vol.50 , pp. 1361-1369
    • Yang, C.Y.1    Lin, M.W.2    Chang, Y.L.3    Wu, C.T.4    Yang, P.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.