IFN-γ-Stimulated Neutrophils Suppress Lymphocyte Proliferation through Expression of PD-L1

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  de Kleijn, Stan ^a   Langereis, Jeroen D ^a   Leentjens, Jenneke ^a   Kox, Matthijs ^a   Netea, Mihai G ^a   Koenderman, Leo ^b   Ferwerda, Gerben ^a   Pickkers, Peter ^a   Hermans, Peter W M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD163 ANTIGEN; GAMMA INTERFERON; L SELECTIN; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROGRAMMED DEATH 1 LIGAND 1;

ARTICLE; CELL INTERACTION; CELL SELECTION; CELL STIMULATION; CONTROLLED STUDY; ENDOTOXEMIA; EX VIVO STUDY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MALE; MICROARRAY ANALYSIS; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SUPPRESSOR CELL;

ANTIGENS, CD274; CELL COMMUNICATION; CELL PROLIFERATION; CELLS, CULTURED; ENDOTOXEMIA; GENE EXPRESSION; HUMANS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MALE; NEUTROPHILS; T-LYMPHOCYTES; TRANSCRIPTOME; UP-REGULATION;

EID: 84883190422     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072249     Document Type: Article

References (28)

1. Borregaard N, (2010) Neutrophils, from marrow to microbes. Immunity 33: 657-670.
2. Mantovani A, Cassatella MA, Costantini C, Jaillon S, (2011) Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 11: 519-531.
3. van Gisbergen KP, Ludwig IS, Geijtenbeek TB, van Kooyk Y, (2005) Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. FEBS Lett 579: 6159-6168.
4. Megiovanni AM, Sanchez F, Robledo-Sarmiento M, Morel C, Gluckman JC, et al. (2006) Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes. J Leukoc Biol 79: 977-988.
5. Pillay J, Ramakers BP, Kamp VM, Loi AL, Lam SW, et al. (2010) Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia. JLeukocBiol 88: 211-220.
6. Pillay J, Kamp VM, van Hoffen E, Visser T, Tak T, et al. (2012) A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1. J Clin Invest 122: 327-336.
7. de Kleijn S, Kox M, Sama IE, Pillay J, van Diepen A, et al. (2012) Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia. PLoS One 7: e38255.
8. Leentjens J, Kox M, Koch RM, Preijers F, Joosten LA, et al. (2012) Reversal of Immunoparalysis in Humans In Vivo: A Double-Blind, Placebo-controlled, Randomized Pilot Study. Am J Respir Crit Care Med 186: 838-845.
9. Gellert P, Uchida S, Braun T, (2009) Exon Array Analyzer: a web interface for Affymetrix exon array analysis. Bioinformatics 25: 3323-3324.
10. Langereis JD, Franciosi L, Ulfman LH, Koenderman L, (2011) GM-CSF and TNFalpha modulate protein expression of human neutrophils visualized by fluorescence two-dimensional difference gel electrophoresis. Cytokine 56: 422-429.
11. Keir ME, Butte MJ, Freeman GJ, Sharpe AH, (2008) PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol 26: 677-704.
12. Hayashi F, Means TK, Luster AD, (2003) Toll-like receptors stimulate human neutrophil function. Blood 102: 2660-2669.
13. Kotz KT, Xiao W, Miller-Graziano C, Qian WJ, Russom A, et al. (2010) Clinical microfluidics for neutrophil genomics and proteomics. NatMed 16: 1042-1047.
14. Boehm U, Klamp T, Groot M, Howard JC, (1997) Cellular responses to interferon-gamma. Annu Rev Immunol 15: 749-795.
15. Kupz A, Guarda G, Gebhardt T, Sander LE, Short KR, et al. (2012) NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8(+) T cells. Nat Immunol 13: 162-169.
16. Rorvig S, Ostergaard O, Heegaard NH, Borregaard N (2013) Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors. J Leukoc Biol.
17. McNab FW, Berry MP, Graham CM, Bloch SA, Oni T, et al. (2011) Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. Eur J Immunol 41: 1941-1947.
18. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, et al. (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466: 973-977.
19. Zhang Y, Li J, Lou J, Zhou Y, Bo L, et al. (2011) Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients. Crit Care 15: R70.
20. Hotchkiss RS, Opal S, (2010) Immunotherapy for sepsis--a new approach against an ancient foe. NEnglJMed 363: 87-89.
21. Cassatella MA, Bazzoni F, Flynn RM, Dusi S, Trinchieri G, et al. (1990) Molecular basis of interferon-gamma and lipopolysaccharide enhancement of phagocyte respiratory burst capability. Studies on the gene expression of several NADPH oxidase components. J Biol Chem 265: 20241-20246.
22. Yoshimura T, Takahashi M, (2007) IFN-gamma-mediated survival enables human neutrophils to produce MCP-1/CCL2 in response to activation by TLR ligands. J Immunol 179: 1942-1949.
23. Bankey PE, Banerjee S, Zucchiatti A, De M, Sleem RW, et al. (2010) Cytokine induced expression of programmed death ligands in human neutrophils. Immunol Lett 129: 100-107.
24. Sheng H, Wang Y, Jin Y, Zhang Q, Zhang Y, et al. (2008) A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res 18: 846-857.
25. Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192: 1027-1034.
26. Rygiel TP, Rijkers ES, de Ruiter T, Stolte EH, van der Valk M, et al. (2009) Lack of CD200 enhances pathological T cell responses during influenza infection. J Immunol 183: 1990-1996.
27. Tate MD, Deng YM, Jones JE, Anderson GP, Brooks AG, et al. (2009) Neutrophils ameliorate lung injury and the development of severe disease during influenza infection. J Immunol 183: 7441-7450.
28. Fujisawa H, (2008) Neutrophils play an essential role in cooperation with antibody in both protection against and recovery from pulmonary infection with influenza virus in mice. J Virol 82: 2772-2783.