Aggregate structure, morphology and the effect of aggregation mechanisms on viscosity at elevated protein concentrations

Biophysical Chemistry

Volumn 207, Issue , 2015, Pages 21-29

  Barnett, Gregory V ^a   Qi, Wei ^b   Amin, Samiul ^b   Neil Lewis, E ^b   Roberts, Christopher J ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b Malvern Biosciences Inc   (United States)

Author keywords

Aggregate mechanism; Protein aggregation; Protein structure; Viscosity

Indexed keywords

CHYMOTRYPSINOGEN; MONOMER; POLYMER;

ARTICLE; BETA SHEET; CIRCULAR DICHROISM; GEL PERMEATION CHROMATOGRAPHY; LIGHT SCATTERING; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN POLYMERIZATION; PROTEIN STRUCTURE; RAMAN SPECTROMETRY; ULTRAVIOLET RADIATION; VISCOSITY; CHEMISTRY; METABOLISM; PHOTON CORRELATION SPECTROSCOPY;

CHYMOTRYPSINOGEN; CIRCULAR DICHROISM; DYNAMIC LIGHT SCATTERING; HYDROGEN-ION CONCENTRATION; SPECTRUM ANALYSIS, RAMAN; VISCOSITY;

EID: 84939217619     PISSN: 03014622     EISSN: 18734200     Source Type: Journal    
DOI: 10.1016/j.bpc.2015.07.002     Document Type: Article

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