Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations

Analytical Biochemistry

Volumn 472, Issue , 2015, Pages 7-20

  Zhou, Chen ^a   Qi, Wei ^b   Lewis, E Neil ^b   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Malvern Instruments Inc   (United States)

Author keywords

Aggregation; Antibody; Dynamic light scattering; Protein formulation; Protein stability; Raman spectroscopy

Indexed keywords

AGGLOMERATION; ANTIBODIES; DYNAMIC LIGHT SCATTERING; HYDRODYNAMICS; ISOTHERMS; RAMAN SPECTROSCOPY; SPECTROMETERS; STABILITY; THERMODYNAMIC STABILITY;

AGGREGATION KINETICS; HUMAN SERUM ALBUMINS; PROTEIN FORMULATION; PROTEIN STABILITY; SECONDARY STRUCTURES; STRUCTURAL PERTURBATION; STRUCTURAL TRANSITIONS; TEMPERATURE INTERVALS;

PROTEINS;

HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN G; HYDROGEN PEROXIDE; IMMUNOGLOBULIN; SERUM ALBUMIN;

ARTICLE; DYNAMIC LIGHT SCATTERING; HEATING; HYDRODYNAMICS; LIGHT SCATTERING; PH; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; RAMAN SPECTROMETRY; TEMPERATURE; THERMOSTABILITY; CHEMISTRY; HEAT; HUMAN; LIGHT; PROCEDURES; PROTEIN STABILITY; RADIATION SCATTERING;

HOT TEMPERATURE; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULINS, INTRAVENOUS; LIGHT; PROTEIN STABILITY; SCATTERING, RADIATION; SERUM ALBUMIN; SPECTRUM ANALYSIS, RAMAN;

EID: 84921021627     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2014.11.016     Document Type: Article

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