Enrichment and purification of casein glycomacropeptide from whey protein isolate using supercritical carbon dioxide processing and membrane ultrafiltration

Foods

Volumn 3, Issue 1, 2014, Pages 94-109

  Bonnaillie, Laetitia M ^a   Qi, Phoebe ^a   Wickham, Edward ^a   Tomasula, Peggy M ^a  

^a EASTERN REGIONAL RESEARCH CENTER   (United States)

Author keywords

Casein glycomacropeptide; Fractionation process; Membrane filtration; Supercritical carbon dioxide; Whey proteins; lactoglobulin

Indexed keywords

EID: 84939197915     PISSN: None     EISSN: 23048158     Source Type: Journal    
DOI: 10.3390/foods3010094     Document Type: Article

References (55)

1. Bonnaillie, L.M.; Tomasula, P.M. Whey Protein Fractionation. In Whey Processing, Functionality and Health Benefits; Onwulata, C.I., Huth, P.J., Eds.; Wiley-Blackwell: Hoboken, NJ, USA, 2008; pp. 15–38.
2. Onwulata, C.I.; Konstance, R.P.; Tomasula, P.M. Minimizing variations in functionality of whey protein concentrates from different sources. J. Dairy Sci. 2004, 87, 749–756.
3. Yver, A.L.; Bonnaillie, L.M.; Yee, W.; McAloon, A.; Tomasula, P.M. Fractionation of whey protein isolate with supercritical carbon dioxide—Process modeling and cost estimation. Int. J. Mol. Sci. 2011, 13, 240–259.
4. Bonnaillie, L.M.; Tomasula, P.M. Kinetics, aggregation behavior and optimization of the fractionation of whey protein isolate with hydrochloric acid. Food Bioprod. Process. 2012, 90, 737–747.
5. Bonnaillie, L.M.; Tomasula, P.M. Fractionation of whey protein isolate with supercritical carbon dioxide to produce enriched α-lactalbumin and β-lactoglobulin food ingredients. J. Agric. Food Chem. 2012, 60, 5257–5266.
6. Bruck, W.M.; Redgrave, M.; Tuohy, K.M.; Lonnerdal, B.; Graverholt, G.; Hernell, O.; Gibson, G.R. Effects of bovine alpha-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants. J. Pediatr. Gastroenterol. Nutr. 2006, 43, 673–679.
7. Sandstrom, O.; Lonnerdal, B.; Graverholt, G.; Hernell, O. Effects of alpha-lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition. Am. J. Clin. Nutr. 2008, 87, 921–928.
8. Heine, W.; Radke, M.; Wietzke, K.D.; Polars, E.; Kundt, G. A-lactalbumin-enriched low-protein infant formulas: A comparison to breast milk feeding. Acta Pediatr. 1996, 85, 1024–1028.
9. Heine, W.E.; Klein, P.D.; Miyashita, C. Method for Isolating Alpha-Lactalbumin from Whey. Patent #WO 92/03468, 5 March 1992.
10. Etzel, M.R. Manufacture and use of dairy protein fractions. J. Nutr. 2004, 134, 996S–1002S.
11. Farrell, H.M., Jr.; Jimenez-Flores, R.; Bleck, G.T.; Brown, E.M.; Butler, J.E.; Creamer, L.K.; Hicks, C.L.; Hollar, C.M.; Ng-Kwai-Hang, K.F.; Swaisgood, H.E. Nomenclature of the proteins of cows’ milk—Sixth revision. J. Dairy Sci. 2004, 87, 1641–1674.
12. Tomasula, P.M.; Craig, J.C., Jr.; Boswell, R.T.; Cook, R.D.; Kurantz, M.J.; Maxwell, M. Preparation of casein using carbon dioxide. J. Dairy Sci. 1995, 78, 506–514.
13. Tomasula, P.M.; Parris, N.; Boswell, R.T.; Moten, R.O. Preparation of enriched fractions of α-lactalbumin and β-lactoglobulin from cheese whey using carbon dioxide. J. Food Process. Preserv. 1998, 22, 463–476.
14. Green, D.; Perry, R. Perry’s Chemical Engineers’ Handbook, 8th ed.; McGraw-Hill Professional: New York, NY, USA, 2007.
15. Fox, P.F.; McSweeney, P. Advanced Dairy Chemistry: Volume 1: Proteins, Parts A & B, 3rd ed.; Springer: Berlin, Germany, 2003.
16. Lopez-Fandino, R.; Ramos, M. Bovine caseinomacropeptide. 1. Physicochemical characteristics and biological-activity—Review. Rev. Esp. Cienc. Tecnol. Aliment. 1992, 32, 575–588.
17. ElSalam, M.H.A.; ElShibiny, S.; Buchheim, W. Characteristics and potential uses of the casein macropeptide. Int. Dairy J. 1996, 6, 327–341.
18. LaClair, C.E.; Ney, D.M.; MacLeod, E.L.; Etzel, M.R. Purification and use of glycomacropeptide for nutritional management of phenylketonuria. J. Food Sci. 2009, 74, E199–E206.
19. Thoma-Worringer, C.; Sorensen, J.; Lopez-Fandino, R. Health effects and technological features of caseinomacropeptide. Int. Dairy J. 2006, 16, 1324–1333.
20. Nejad, A.S.; Kanekanian, A.; Tatham, A. The inhibitory effect of glycomacropeptide on dental erosion. Dairy Sci. Technol. 2009, 89, 233–239.
21. Setarehnejad, A.; Kanekanian, A.; Tatham, A.; Abedi, A.H. The protective effect of caseinomacropeptide against dental erosion using hydroxyapatite as a model system. Int. Dairy J. 2010, 20, 652–656.
22. Requena, P.; Gonzalez, R.; Lopez-Posadas, R.; Abadia-Molina, A.; Suarez, M.D.; Zarzuelo, A.; de Medina, F.S.; Martinez-Augustin, O. The intestinal antiinflammatory agent glycomacropeptide has immunomodulatory actions on rat splenocytes. Biochem. Pharm. 2010, 79, 1797–1804.
23. Hursel, R.; van der Zee, L.; Westerterp-Plantenga, M.S. Effects of a breakfast yoghurt, with additional total whey protein or caseinomacropeptide-depleted alpha-lactalbumin-enriched whey protein, on diet-induced thermogenesis and appetite suppression. Br. J. Nutr. 2010, 103, 775–780.
24. Li, E.W.Y.; Mine, Y. Technical note: Comparison of chromatographic profile of glycomacropeptide from cheese whey isolated using different methods. J. Dairy Sci. 2004, 87, 174–177.
25. Da Silva, C.A.S.; Coimbra, J.S.R.; Rojas, E.E.G.; Teixeira, J.A.C. Partitioning of glycomacropeptide in aqueous two-phase systems. Process Biochem. 2009, 44, 1213–1216.
26. Casal, E.; Corzo, N.; Moreno, F.J.; Olano, A. Selective recovery of glycosylated caseinmacropeptide with chitosan. J. Agric. Food Chem. 2005, 53, 1201–1204.
27. Tolkach, A.; Kulozik, U. Fractionation of whey proteins and caseinomacropeptide by means of enzymatic crosslinking and membrane separation techniques. J. Food Eng. 2005, 67, 13–20.
28. Nakano, T.; Ikawa, N.; Ozimek, L. Separation of glycomacropeptide from sweet whey by using chitosan and a centrifugal filter. Milchwissenschaft 2006, 61, 191–193.
29. Chu, L.; Macleod, A.; Ozimek, L. Isolation of glycomacropeptide from sodium caseinate hydrolysate solution by ultrafiltration. Milchwissenschaft 1996, 51, 303–306.
30. Tanimoto, M.; Kawasaki, Y.; Shinmoto, H.; Dosako, S.; Tomizawa, A. Process for Producing κ-Casein Glycomacropeptides. US Patent No. 5,075,424, 24 December 1991.
31. Kawasaki, Y.; Kawakami, M.; Tanimoto, M.; Dosako, S.; Tomizawa, A.; Kotake, M.; Naka-jima, I. pH-dependent molecular weight changes of κ-casein glyco-macropeptide and its preparation by ultrafiltration. Milchwissenschaft 1993, 48, 191–196.
32. Martin-Diana, A.B.; Fraga, M.J.; Fontecha, J. Isolation and characterisation of caseinmacropeptide from bovine, ovine, and caprine cheese whey. Eur. Food Res. Technol. 2002, 214, 282–286.
33. Kreuss, M.; Kulozik, U. Separation of glycosylated caseinomacropeptide at pilot scale using membrane adsorption in direct-capture mode. J. Chromatogr. A 2009, 1216, 8771–8777.
34. Lieske, B.; Konrad, G.; Kleinschmidt, T. Isolation of caseinomacropeptide from rennet whey by a multistage ultrafiltration process. III. Influence of pH in the first ultrafiltration-step on the chemical properties of isolated caseinomacropeptide. Milchwissenschaft 2004, 59, 408–410.
35. Ayers, J.S.; Elgar, D.F.; Palmano, K.P.; Pritchard, M.; Bhaskar, G.B. Process for Separation of Whey Proteins Using a Novel Anion Exchanger. Patent CA2393270 A1, 28 March 2006.
36. Outinen, M.; Tossavainen, O.; Syvaoja, E.L.; Korhonen, H. Chromatographic isolation of kappa-casein macropeptide from cheese whey with a strong basic anion-exchange resin. Milchwissenschaft 1995, 50, 570–574.
37. Doultani, S.; Turhan, K.N.; Etzel, M.R. Whey protein isolate and glycomacropeptide recovery from whey using ion exchange chromatography. J. Food Sci. 2003, 68, 1389–1395.
38. Tek, H.N.; Turhan, K.N.; Etzel, M.R. Effect of conductivity, pH, and elution buffer salinity on glycomacropeptide recovery from whey using anion exchange chromatography. J. Food Sci. 2005, 70, E295–E300.
39. Kreuss, M.; Krause, I.; Kulozik, U. Separation of a glycosylated and non-glycosylated fraction of caseinomacropeptide using different anion-exchange stationary phases. J. Chromatogr. A 2008, 1208, 126–132.
40. Holland, B.; Yazdi, S.R.; Titapiccolo, G.I.; Corredig, M. Short communication: Separation and quantification of caseins and casein macropeptide using ion-exchange chromatography. J. Dairy Sci. 2010, 93, 893–900.
41. Kawakami, H.; Kawasaki, Y.; Dosako, S.; Tanimoto, M.; Nakajima, I. Determination of κ-casein glycomacropeptide by high-performance liquid-chromatography without trichloroacetic-acid pretreatment. Milchwissenschaft 1992, 47, 688–693.
42. Shammet, K.M.; Mcmahon, D.J.; Brown, R.J. Characteristics of macropeptide fraction isolated from whole casein and purified κ-casein. Milchwissenschaft 1992, 47, 615–619.
43. Minkiewicz, P.; Slangen, C.J.; Lagerwerf, F.M.; Haverkamp, J.; Rollema, H.S.; Visser, S. Reversed-phase high-performance liquid chromatographic separation of bovine κ-casein macropeptide and characterization of isolated fractions. J. Chromatogr. A 1996, 743, 123–135.
44. Elgar, D.F.; Norris, C.S.; Ayers, J.S.; Pritchard, M.; Otter, D.E.; Palmano, K.P. Simultaneous separation and quantitation of the major bovine whey proteins including proteose peptone and caseinomacropeptide by reversed-phase high-performance liquid chromatography on polystyrene-divinylbenzene. J. Chromatogr. A 2000, 878, 183–196.
45. Ferreira, I.M.P.L.V.O.; Oliveira, M.B.P.P. Determination of caseinomacropeptide by an RP-HPLC method and monitoring of the addition of rennet whey to powdered milk. J. Liq. Chromatogr. Relat. Technol. 2003, 26, 99–107.
46. Thoma, C.; Krause, I.; Kulozik, U. Precipitation behaviour of caseinomacropeptides and their simultaneous determination with whey proteins by RP-HPLC. Int. Dairy J. 2006, 16, 285–293.
47. Vanriel, J.; Olieman, C. Determination of caseinomacropeptide with capillary zone electrophoresis and its application to the detection and estimation of rennet whey solids in milk and buttermilk powder. Electrophoresis 1995, 16, 529–533.
48. Molle, D.; Leonil, J. Quantitative determination of bovine κ-casein macropeptide in dairy products by liquid chromatography/electrospray coupled to mass spectrometry (LC-ESI/MS) and liquid chromatography/electrospray coupled to tamdem mass spectrometry (LC-ESI/MS/MS). Int. Dairy J. 2005, 15, 419–428.
49. Galindo-Amaya, L.; Valbuena-Colmenares, E.; Rojas-Villarroel, E. Standardization of glycomacropeptide detection with SDS-PAGE as a milk adulteration index. Rev. Cient. 2006, 16, 308–314.
50. Grindrod, J.; Nickerso, T.A. Glycomacropeptide identification by disc gel electrophoresis. Abstracts of papers presented at the Sixtieth Annual Meeting of the American Dairy Science Association: University of Kentucky, Lexington, June 20–23, 1965. J. Dairy Sci. 1965, 48, 762–830
51. Parris, N.; White, A.E.; Farrell, H.M. Identification of altered proteins in nonfat dry milk powder prepared from heat-treated skim milk. J. Agric. Food Chem. 1990, 38, 824–829.
52. Barbano, D.M.; Lynch, J.M.; Fleming, J.R. Direct and indirect determination of true protein content of milk by kjeldahl analysis: Collaborative study. J. Assoc. Off. Anal. Chem. 1991, 74, 281–288.
53. McGuffey, M.K.; Epting, K.L.; Kelly, R.M.; Foegeding, E.A. Denaturation and aggregation of three alpha-lactalbumin preparations at neutral pH. J. Agric. Food Chem. 2005, 53, 3182–3190.
54. De Wit, J.N. Functional Properties of Whey Proteins. In Developments in Dairy Chemistry; Fox, P.F., Ed.; Elsevier Applied Science: New York, NY, USA, 1989; Volume 4.
55. Verheul, M.; Pedersen, J.S.; Roefs, S.P.F.M.; de Kruif, K.G. Association behavior of native β-lactoglobulin. Biopolymers 1999, 49, 11–20.