Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer’s disease mutation is normalized with a benzodiazepine

Neurobiology of Disease

Volumn 7, Issue 1, 2000, Pages 54-63

  Zaman, Shahid H ^a   Parent, Angèle ^b   Laskey, Aaron ^a   Lee, Michael K ^b   Borchelt, David R ^b   Sisodia, Sangram S ^b,c   Malinow, Roberto ^a  

^a Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE; PRESENILIN 1;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; GENE EXPRESSION; GENE MUTATION; LONG TERM POTENTIATION; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; SYNAPTIC INHIBITION; TRANSGENIC MOUSE;

EID: 0034095106     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1999.0271     Document Type: Article

References (39)

1. Begley J. G., Duan W., Chan S., Duff K., Mattson M. P. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. J. Neurochem. 72:1999;1030-1039.
2. Bliss T. V., Collingridge G. L. A synaptic model of memory: Long-term potentiation in the hippocampus. Nature. 361:1993;31-39.
3. Borchelt D. R., Thinakaran G., Eckman C. B., Lee M. K., Davenport F., Ratovitsky T., Prada C. M., Kim G., Seekins S., Yager D., Slunt H. H., Wang R., Seeger M., Levey A. I., Gandy S. E., Copeland N. G., Jenkins N. A., Price D. L., Younkin S. G., Sisodia S. S. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17:1996;1005-1013.
4. Borchelt D. R., Ratovitski T., van Lare J., Lee M. K., Gonzales V., Jenkins N. A., Copeland N. G., Price D. L., Sisodia S. S. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron. 19:1997;939-945.
5. Bramham C. R., Srebro B. Synaptic plasticity in the hippocampus is modulated by behavioral state. Brain Res. 493:1989;74-86.
6. Busciglio J., Hartmann H., Lorenzo A., Wong C., Baumann K., Sommer B., Staufenbiel M., Yankner B. A. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J. Neurosci. 17:1997;5101-5107.
7. Buzsaki G. J. Memory consolidation during sleep: A neurophysical perspective. Sleep Res. 7:1998;17-23.
8. Cook D. G., Sung J. C., Golde T. E., Felsenstein K. M., Wojczyk B. S., Tanzi R. E., Trojanowski J. Q., Lee V. M., Doms R. W. Expression and analysis of presenilin 1 in a human neuronal system: Localization in cell bodies and dendrites. Proc. Natl. Acad. Sci. USA. 93:1996;9223-9228.
9. Culvenor J. G., Maher F., Evin G., Malchiodi-Albedi F., Cappai R., Underwood J. R., Davis J. B., Karran E. H., Roberts G. W., Beyreuther K. Alzheimer's disease-associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum-Golgi intermediate compartment. J. Neurosci. Res. 49:1997;719-731.
10. Evans D. A., Funkenstein H. H., Albert M. S., Scherr P. A., Cook N. R., Chown M. J., Hebert L. E., Hennekens C. H., Taylor J. O. Prevalence of Alzheimer's disease in a community population of older persons. Higher than previously reported. JAMA. 262:1989;2551-2556.
11. Evans M. S., Viola-McCabe K. E. Midazolam inhibits long-term potentiation through modulation of GABAA receptors. Neuropharmacology. 35:1996;347-357.
12. Fastbom J., Forsell Y., Winblad B. Benzodiazepines may have protective effects against Alzheimer disease. Alzheimer Dis. Assoc. Disord. 12:1998;14-17.
13. Guo Q., Furukawa K., Sopher B. L., Pham D. G., Xie J., Robinson N., Martin G. M., Mattson M. P. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. NeuroReport. 8:1996;379-383.
14. Guo Q., Fu W., Sopher B. L., Miller M. W., Ware C. B., Martin G. M., Mattson M. P. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant. Nat. Med. 5:1999;101-106.
15. Herron C. E., Lester R. A., Coan E. J., Collingridge G. L. Frequency-dependent involvement of NMDA receptors in the hippocampus: A novel synaptic mechanism. Nature. 322:1986;265-268.
16. Holcomb L., Gordon M. N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C. M., Eckman C., Younkin S., Hsiao K., Duff K. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 4:1998;97-100.
17. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
18. Kavanau J. L. Memory, sleep and the evolution of mechanisms of synaptic efficacy maintenance. Neuroscience. 79:1997;7-44.
19. Kovacs D. M., Fausett H. J., Page K. J., Kim T. W., Moir R. D., Merriam D. E., Hollister R. D., Hallmark O. G., Mancini R., Felsenstein K. M., Hyman B. T., Tanzi R. E., Wasco W. Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat. Med. 2:1996;224-229.
20. Lah J. J., Heilman C. J., Nash N. R., Rees H. D., Yi H., Counts S. E., Levey A. I. Light and electron microscopic localization of presenilin-1 in primate brain. J. Neurosci. 17:1997;1971-1980.
21. Lee M. K., Slunt H. H., Martin L. J., Thinakaran G., Kim G., Gandy S. E., Seeger M., Koo E., Price D. L., Sisodia S. S. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. J. Neurosci. 16:1996;7513-7525.
22. Lee M. K., Borchelt D. R., Kim G., Thinakaran G., Slunt H. H., Ratovitski T., Martin L. J., Kittur A., Gandy S., Levey A. I., Jenkins N., Copeland N., Price D. L., Sisodia S. S. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nat. Med. 3:1997;756-760.
23. Levy-Lahad E., Wasco W., Poorkaj P., Romano D. M., Oshima J., Pettingell W. H., Yu C. E., Jondro P. D., Schmidt S. D., Wang K., Crowley A. C., Fu Y.-H., Guenette S. Y., Galas D., Nemens E., Wijsmen E. M., Bird T. D., Schellenberg G. D., Tanzi R. E. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269:1995;973-977.
24. Malinow R., Tsien R. W. Presynaptic enhancement shown by whole-cell recordings of long-term potentiation in hippocampal slices. Nature. 346:1990;177-180.
25. Migaud M., Charlesworth P., Dempster M., Webster L. C., Watabe A. M., Makhinson M., He Y., Ramsay M. F., Morris R. G. M., Morrison J. H., O'Dell T. J., Grant S. G. N. Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein. Nature. 396:1998;433-439.
26. Moussaoui S., Czech C., Pradier L., Blanchard V., Bonici B., Gohin M., Imperato A., Revah F. Immunohistochemical analysis of presenilin-1 expression in the mouse brain. FEBS Lett. 383:1996;219-222.
27. A receptor activation attenuates excitotoxicity but exacerbates oxygen-glucose deprivation-induced neuronal injury in vitro. J. Cereb. Blood Flow Metab. 16:1996;1211-1218.
28. Ohkuma S., Chen S. H., Katsura M., Chen D. Z., Kuriyama K. Muscimol prevents neuronal injury induced by NMDA. Jpn. J. Pharmacol. 64:1994;125-128.
29. Parent A., Linden D. J., Sisodia S. S., Borchelt D. Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiol. Dis. 6:1999;56-62.
30. Price D. L., Sisodia S. S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21:1998;479-505.
31. Querfurth H. W., Jiang J., Geiger J. D., Selkoe D. J. Caffeine stimulates amyloid beta-peptide release from beta-amyloid precursor protein-transfected HEK293 cells. J. Neurochem. 69:1997;1580-1591.
32. A receptor benzodiazepine site ligands. Neuropharmacology. 36:1997;823-830.
33. Sherrington R., Rogaev E. I., Liang Y., Rogaeva E. A., Levesque G., Ikeda M., Chi H., Lin C., Li G., Holman K., Tsuda T., Mar L., Foncin J. F., Bruni A., Montesi M. P., Sorbi S., Rainero I., Pinessi L., Nee L., Chumakov I., Pollen D. A., Roses A. D., Fraser P. E., Rommens J. M., St. George-Hyslop P. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375:1995;754-760.
34. St. George-Hyslop P. H. Genetics of Alzheimer's disease. Markesbery W. R. Neuropathology of Dementing Disorders. 1998;106-120 Arnold, London.
35. Thinakaran G., Borchelt D. R., Lee M. K., Slunt H. H., Spitzer L., Kim G., Ratovitsky T., Davenport F., Nordstedt C., Seeger M., Hardy J., Levey A. I., Gandy S. E., Jenkins N. A., Copeland N. G., Price D. L., Sisodia S. S. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17:1996;181-190.
36. Uchihara T., el Hachimi H. K., Duyckaerts C., Foncin J. F., Fraser P. E., Levesque L., St. George-Hyslop P. H., Hauw J. J. Widespread immunoreactivity of presenilin in neurons of normal and Alzheimer's disease brains: Double-labeling immunohistochemical study. Acta Neuropathol. (Berlin). 92:1996;325-330.
37. Walter J., Capell A., Grunberg J., Pesold B., Schindzielorz A., Prior R., Podlisny M. B., Fraser P., Hyslop P. S., Selkoe D. J., Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Mol. Med. 2:1996;673-691.
38. Wigstrom H., Gustafsson. Postsynaptic control of hippocampal long-term potentiation. J. Physiol. (Paris). 81:1986;228-236.
39. Zucker R. S. Short-term synaptic plasticity. Annu. Rev. Neurosci. 12:1989;13-31.