Novel self-assembled nano-tubular mixed micelles of Pluronics P123, Pluronic F127 and phosphatidylcholine for oral delivery of nimodipine: In vitro characterization, ex vivo transport and in vivo pharmacokinetic studies

International Journal of Pharmaceutics

Volumn 493, Issue 1-2, 2015, Pages 347-356

  Basalious, Emad B ^a   Shamma, Rehab N ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Nano tubular mixed micelles; Nimodipine; Phosphatidylcholine; Pluronics; Subarachnoid hemorrhage; Thermodynamic stability of micelles

Indexed keywords

NIMODIPINE; PHOSPHATIDYLCHOLINE; POLOXAMER; POLYSORBATE 80; CALCIUM CHANNEL BLOCKING AGENT; MICELLE; NANOTUBE; PLURONIC BLOCK COPOLYMER P123;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CIRCULATION TIME; CONTROLLED STUDY; DILUTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG METABOLISM; DRUG SOLUBILITY; DRUG SOLUTION; DRUG TRANSPORT; ELIMINATION HALF-LIFE; EX VIVO STUDY; HYDRATION; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE ABSORPTION; MALE; MICELLE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SOLUBILIZATION; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL; ANIMAL; BIOAVAILABILITY; BLOOD; BRAIN; CHEMISTRY; METABOLISM; ORAL DRUG ADMINISTRATION; SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BRAIN; CALCIUM CHANNEL BLOCKERS; INTESTINAL ABSORPTION; MALE; MICELLES; NANOTUBES; NIMODIPINE; PHOSPHATIDYLCHOLINES; POLOXALENE; POLOXAMER; RATS, WISTAR; SOLUBILITY;

EID: 84939138282     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.07.075     Document Type: Article

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