Adoption of polymeric micelles to enhance the oral bioavailability of dexibuprofen: Formulation, in-vitro evaluation and in-vivo pharmacokinetic study in healthy human volunteers

Pharmaceutical Development and Technology

Volumn 19, Issue 6, 2014, Pages 717-727

  Abdelbary, Ghada ^a   Makhlouf, Amal ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Dexibuprofen; Healthy human volunteers; Pharmacokinetic study; Pluronics; Polymeric micelles

Indexed keywords

CRYOPROTECTIVE AGENT; DEXIBUPROFEN; POLOXAMER; POLYMER;

AREA UNDER THE CURVE; ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG RELEASE; DRUG SOLUBILITY; FILM; FREEZE DRYING; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MICELLE; NORMAL HUMAN; PARTICLE SIZE; PLASMA CONCENTRATION-TIME CURVE; POLYMERIZATION; PRIORITY JOURNAL; SOLID STATE; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET FRIABILITY; TABLET HARDNESS; TIME TO MAXIMUM PLASMA CONCENTRATION; TRANSMISSION ELECTRON MICROSCOPY;

ADMINISTRATION, ORAL; ADULT; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; HUMANS; IBUPROFEN; MALE; MICELLES; PARTICLE SIZE; POLOXAMER; POLYMERS; SOLUBILITY; TABLETS;

EID: 84899849685     PISSN: 10837450     EISSN: 10979867     Source Type: Journal    
DOI: 10.3109/10837450.2013.823994     Document Type: Article

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