Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

Journal of the American Chemical Society

Volumn 137, Issue 31, 2015, Pages 9885-9893

  Winter, Jaclyn M ^a,f   Cascio, Duilio ^c   Dietrich, David ^d   Sato, Michio ^e   Watanabe, Kenji ^e   Sawaya, Michael R ^c   Vederas, John C ^d   Tang, Yi ^a,b  

^a University of California   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF ALBERTA   (Canada)

^e UNIVERSITY OF SHIZUOKA   (Japan)

^f UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; FUNGI; KETONES; PROTEINS;

ACYL CARRIER PROTEINS; NATURAL PRODUCTS; POLYKETIDE BIOSYNTHESIS; POLYKETIDE SYNTHASES; PROTEIN ENGINEERING; STRUCTURAL BASIS; STRUCTURAL DIVERSITY; SUBSTRATE CHANNELINGS;

CRYSTAL STRUCTURE;

BENZALDEHYDE DERIVATIVE; CHAETOMUGILIN AZAPHILONE; CHAETOVIRIDIN; POLYKETIDE SYNTHASE; THIOESTER; UNCLASSIFIED DRUG; POLYKETIDE;

ARTICLE; BIOCHEMISTRY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME SYNTHESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN ENGINEERING; CHAETOMIUM; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR MODEL; PROTEIN TERTIARY STRUCTURE;

CHAETOMIUM; MODELS, MOLECULAR; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN STRUCTURE, TERTIARY;

EID: 84938931415     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.5b04520     Document Type: Article

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