A polyketide synthase acyltransferase domain structure suggests a recognition mechanism for its hydroxymalonyl-acyl carrier protein substrate

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Park, Hyunjun ^a   Kevany, Brian M ^a,b   Dyer, David H ^a   Thomas, Michael G ^a   Forest, Katrina T ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 METHYLMALONYL COENZYME A; ACYLTRANSFERASE; CARRIER PROTEIN; COENZYME A; HYDROXYMALONYL ACYL CARRIER PROTEIN; MALONYL ACYL CARRIER PROTEIN; MALONYL COENZYME A; METHYLMALONYL ACYL CARRIER PROTEIN; POLYKETIDE SYNTHASE; PROTEIN PRECURSOR; SOLVENT; TARTRONIC ACID; UNCLASSIFIED DRUG; ACYL CARRIER PROTEIN; BACTERIAL PROTEIN; MULTIENZYME COMPLEX; PEPTIDE; TARTRONIC ACID DERIVATIVE; ZWITTERMICIN A;

ARTICLE; BINDING SITE; BIOENGINEERING; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; HYDROPHOBICITY; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; STRUCTURE ANALYSIS; X RAY; BACILLUS CEREUS; CHEMISTRY; ENZYMOLOGY; MOLECULAR CLONING; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; X RAY CRYSTALLOGRAPHY;

ACYL CARRIER PROTEIN; ACYLTRANSFERASES; AMINO ACID MOTIFS; BACILLUS CEREUS; BACTERIAL PROTEINS; CATALYTIC DOMAIN; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; MULTIENZYME COMPLEXES; PEPTIDES; POLYKETIDE SYNTHASES; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY; TARTRONATES;

EID: 84908577862     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0110965     Document Type: Article

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