Normal or high polyphenol concentration in orange juice affects antioxidant activity, blood pressure, and body weight in obese or overweight adults

Journal of Nutrition

Volumn 145, Issue 8, 2015, Pages 1808-1816

  Rangel Huerta, Oscar D ^a   Aguilera, Concepcion M ^a   Martin, Maria V ^a   Soto, Maria J ^b,e   Rico, Maria C ^a   Vallejo, Fernando ^c,f   Tomas Barberan, Francisco ^c,f   Perez de la Cruz, Antonio J ^a,d   Gil, Angel ^a   Mesa, Maria D ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b Center for Studies of Sensory Impairment Aging and Metabolism Guatemala   (Guatemala)

^c RESEARCH GROUP ON QUALITY   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^e Section 3163/Guatemala   (United States)

^f UNIVERSITY OF MURCIA   (Spain)

Author keywords

Antioxidants; Flavanones; Obesity; Orange juice; Oxidative stress

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 ISOPROSTAGLANDIN F2 ALPHA; BIOLOGICAL MARKER; CREATININE; HEMOGLOBIN; LEPTIN; LIPID PEROXIDE; OXIDIZED LOW DENSITY LIPOPROTEIN; POLYPHENOL; SUPEROXIDE DISMUTASE; ANTIOXIDANT;

ADULT; ANTHROPOMETRIC PARAMETERS; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; HEMOGLOBIN DETERMINATION; HUMAN; METABOLIC SYNDROME X; OBESITY; ORANGE JUICE; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE; URINALYSIS; WAIST CIRCUMFERENCE; ANALYSIS; BEVERAGE; BLOOD; CHEMISTRY; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG EFFECTS; FEMALE; MALE; SWEET ORANGE;

ADULT; ANTIOXIDANTS; BEVERAGES; BIOLOGICAL MARKERS; BLOOD PRESSURE; CITRUS SINENSIS; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; OVERWEIGHT; OXIDATIVE STRESS; POLYPHENOLS;

EID: 84938921514     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.115.213660     Document Type: Article

References (51)

1. Martinez Cayuela M, Gil A. Oxidative stress and antioxidant defense mechanisms. In: Treaty of Nutrition. Physiological and biochemical basis of nutrition. Vol. 1, 2nd ed. Madrid (Spain): Ed. Medica Panamericana;2010:455-80.
2. Tsai SJ, Huang CS, Mong MC, Kam WY, Huang HY, Yin MC. Antiinflammatory and antifibrotic effects of naringenin in diabetic mice. J Agric Food Chem 2012;60:514-21.
3. Assini JM, Mulvihill EE, Huff MW. Citrus flavonoids and lipid metabolism. Curr Opin Lipidol 2013;24:34-40.
4. Bernabe J, Mulero J, Cerda B, Garcia-Viguera C, Moreno DA, Parra S, Aviles F, Gil-Izquierdo A, Abellan J, Zafrilla P. Effects of a citrus based juice on biomarkers of oxidative stress in metabolic syndrome patients. J Funct Foods. 2013;5:1031-8.
5. Roowi S, Mullen W, Edwards CA, Crozier A. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Mol Nutr Food Res 2009;53:S68-75.
6. Pérez-Jiménez J, Hubert J, Hooper L, Cassidy A, Manach C, Williamson G, Scalbert A. Urinary metabolites as biomarkers of polyphenol intake in humans: a systematic review. Am J Clin Nutr 2010;92:801-9.
7. Dalgård C, Nielsen F, Morrow JD, Enghusen-Poulsen H, Jonung T, HorderM, deMaat MPM. Supplementation with orange and blackcurrant juice, but not vitamin E, improves inflammatory markers in patients with peripheral arterial disease. Br J Nutr 2009;101:263-9.
8. Perron NR, García CR, Pinzon JR, Chaur MN, Brumaghim JL. Antioxidant and prooxidant effects of polyphenol compounds on copper-mediated DNA damage. J Inorg Biochem 2011;105:745-53.
9. Carocho M, Ferreira ICFR. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem Toxicol 2013;51:15-25.
10. Yen GC, Duh PD, Tsai HL, Huang SL. Pro-oxidative properties of flavonoids in human lymphocytes. Biosci Biotechnol Biochem 2003;67:1215-22.
11. Pond AL, Zamora JM, Wells MR. Effect of the bioflavonoid morin on HEp-2 cells. Bull Environ Contam Toxicol 1994;53:562-9.
12. Alberti KG, Zimmet P, Shaw J, IDF Epidemiology Task Force Consensus Group. The metabolic syndrome-a new worldwide definition. Lancet 2005;366:1059-62.
13. Kawashima A, Madarame T, Koike H, Komatsu Y, Wise JA. Four week supplementation with mixed fruit and vegetable juice concentrates increased protective serum antioxidants and folate and decreased plasma homocysteine in Japanese subjects. Asia Pac J Clin Nutr 2007;16:411-21.
14. Martin-Moreno JM, Boyle P, Gorgojo L, Maisonneuve P, Fernandez-Rodriguez JC, Salvini S, Willett WC. Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol 1993;22:512-9.
15. University of Granada. Food and Health software (AyS). Spanish Database of Food Composition (BEDCA) version 1.0. The Spanish Agency of Food Security (AESAN) [Internet]. c2010 [cited 2015 Feb 27]. Available from: http://www.bedca.net/.
16. Tomás-Navarro M, Vallejo F, Sentandreu E, Navarro JL, Tomas-Barberan FA. Volunteer stratification is more relevant than technological treatment in orange juice flavanone bioavailability. J Agric Food Chem 2014;62:24-7.
17. Drabkin DL. The standardization of hemoglobin measurement. Am J Med Sci 1948;215:110.
18. Aebi H. Catalase in vitro. Methods Enzymol 1984;105:121-6.
19. McCord JM, Fridovich I. The utility of superoxide dismutase in studying free radical reactions. I. Radicals generated by the interaction of sulfite, dimethyl sulfoxide, and oxygen. J Biol Chem 1969;244:6056-63.
20. Flohé L, Günzler WA. Assays of glutathione peroxidase. Methods Enzymol 1984;105:114-21.
21. Carlberg I, Mannervik B. Glutathione reductase. Methods Enzymol 1985;113:484-90.
22. Hollman PC, Cassidy A. The biological relevance of direct antioxidant effects of polyphenols for cardiovascular health in humans is not established. J Nutr 2011;141:989S-1009S.
23. SchärMY, Curtis PJ, Hazim S, Ostertag LM, Kay CD, Potter JF, Cassidy A. Orange juice-derived flavanone and phenolic metabolites do not acutely affect cardiovascular risk biomarkers: a randomized, placebocontrolled, crossover trial in men at moderate risk of cardiovascular disease. Am J Clin Nutr 2015;101:931-8.
24. Sánchez-Moreno C, Cano MP, de Ancos B, Plaza L, Olmedilla B, Granado F, Martin A. Effect of orange juice intake on vitamin C concentrations and biomarkers of antioxidant status in humans. Am J Clin Nutr 2003;78:454-60.
25. Galati G, O'Brien PJ. Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties. Free Radic Biol Med 2004;37:287-303.
26. Wu LL, Chiou C-C, Chang P-Y, Wu JT. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 2004;339:1-9.
27. Tirkey N, Pilkhwal S, Kuhad A, Chopra K. Hesperidin, a citrus bioflavonoid, decreases the oxidative stress produced by carbon tetrachloride in rat liver and kidney. BMC Pharmacol 2005;5:2.
28. Pérez DD, Strobel P, Foncea R, Diez M. Wine, diet, antioxidant defenses, and oxidative damage. Ann N Y Acad Sci 2002;957:136-45.
29. Jomova K, Valko M. Health protective effects of carotenoids and their interactions with other biological antioxidants. Eur J Med Chem 2013;70:102-10.
30. Morand C, Dubray C, Milenkovic D. Hesperidin contributes to the vascular protective effects of orange juice: a randomized crossover study in healthy volunteers. Am J Clin Nutr 2011;93:73-80.
31. Landete JM. Dietary intake of natural antioxidants: vitamins and polyphenols. Crit Rev Food Sci Nutr 2013;53:706-21.
32. Mahmoud AM, Ashour MB, Adel A-M, Ahmed OM, Abdel-Moneim A. Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocininduced type 2 diabetic rats. J Diabetes Complications 2012;26:483-90.
33. Niki E. Role of vitamin E as lipid-soluble peroxyl radical scavenger:In vitro and in vivo evidence. Free Radic Biol Med 2014;66:3-12.
34. Jeon SM, Bok SH, Jang MK, Kim YH, Nam KT, Jeong TS, Park YB, Choi MS. Comparison of antioxidant effects of naringin and probucol in cholesterol-fed rabbits. Clin Chim Acta 2002;317:181-90.
35. Codoñer-Franch P, Lopez-Jaén AB, Muñiz P, Sentandreu E, Belles VV. Mandarin juice improves the antioxidant status of hypercholesterolemic children. J Pediatr Gastroenterol Nutr 2008;47:349-55.
36. Garg A, Garg S, Zaneveld LJ, Singla AK. Chemistry and pharmacology of the citrus bioflavonoid hesperidin. Phytother Res 2001;15:655-69.
37. Wilmsen PK, Spada DS, Salvador M. Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J Agric Food Chem 2005;53:4757-61.
38. Jain M, Singh H, Parmar HS. Evaluation of antioxidative and antiinflammatory potential of hesperidin and naringin on the rat air pouch model of inflammation. Inflamm Res 2011;60:483-91.
39. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4:118-26.
40. Shi X, Liao S, Mi H, Guo C, Qi D, Li F, Zhang C, Yang Z. Hesperidin prevents retinal and plasma abnormalities in streptozotocin-induced diabetic rats. Molecules 2012;17:12868-81.
41. Choi EJ. Antioxidative effects of hesperetin against 7,12-dimethylbenz (a)anthracene-induced oxidative stress in mice. Life Sci 2008;82:1059-64.
42. Jeon SM, Bok SH, Jang MK, Lee MK, Nam KT, Park YB, Rhee SJ, Choi MS. Antioxidative activity of naringin and lovastatin in high cholesterol-fed rabbits. Life Sci 2001;69:2855-66.
43. Rajadurai M, Prince PSM. Naringin ameliorates mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol-induced myocardial infarction in Wistar rats. Phytother Res 2009;23:358-62.
44. Cilla A, De Palma G, Lagarda MJ, Barbera R, Farre R, Clemente G, Romero F. Impact of fruit beverage consumption on the antioxidant status in healthy women. Ann Nutr Metab 2009;54:35-42.
45. Galleano M, Calabro V, Prince PD, Litterio MC, Piotrkowski B, Vazquez-Prieto MA, Miatello RM, Oteiza PI, Fraga CG. Flavonoids and metabolic syndrome. Ann N Y Acad Sci 2012;1259:87-94.
46. Yamamoto M, Suzuki A, Hase T. Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 2008;54:95-8.
47. Demonty I, Lin Y. The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. J Nutr 2010;140:1615-20.
48. Kurowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piché LA, Serratore P. HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia. Am J Clin Nutr 2000;72:1095-100.
49. Miwa Y, Mitsuzumi H, Sunayama T, Yamada M, Okada K, Kubota M, Chaen H, Mishima Y, Kibata M. Glucosyl hesperidin lowers serum triglyceride level in hypertriglyceridemic subjects through the improvement of very low-density lipoprotein metabolic abnormality. J Nutr Sci Vitaminol (Tokyo) 2005;51:460-70.
50. Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW. Secretion of hepatocyte apoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. J Lipid Res 2001;42:725-34.
51. Mulvihill EE, Allister EM, Sutherland BG, Telford DE, Sawyez CG, Edwards JY, Markle JM, Hegele RA, Huff MW. Naringenin prevents dyslipidemia, apolipoprotein B overproduction, and hyperinsulinemia in LDL receptor-null mice with diet-induced insulin resistance. Diabetes 2009;58:2198-210.