The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice

Journal of Functional Foods

Volumn 17, Issue , 2015, Pages 115-126

  Karthivashan, Govindarajan ^a   Arulselvan, Palanisamy ^a   Tan, Sheau Wei ^a   Fakurazi, Sharida ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Antioxidant enzyme; Antioxidant response element (ARE); Cytochrome P450 2E1 1A2 2A6; Inflammatory cytokines; Nuclear factor erythroid 2 related factor 2 (Nrf2)

Indexed keywords

MORINGA OLEIFERA; MUS;

EID: 84938876799     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2015.05.007     Document Type: Article

References (43)

1. Aleksunes L.M., Manautou J.E. Emerging role of Nrf2 in protecting against hepatic and gastrointestinal disease. Toxicologic Pathology 2007, 35(4):459-473.
2. Anwar F., Latif S., Ashraf M., Gilani A.H. Moringa oleifera: A food plant with multiple medicinal uses. Phytotherapy Research 2007, 21(1):17-25.
3. Bourdi M., Masubuchi Y., Reilly T.P., Amouzadeh H.R., Martin J.L., George J.W., Pohl L.R. Protection against acetaminophen-induced liver injury and lethality by interleukin 10: Role of inducible nitric oxide synthase. Hepatology (Baltimore, Md.) 2002, 35(2):289-298.
4. Chen W., Koenigs L.L., Thompson S.J., Peter R.M., Rettie A.E., Trager W.F., Nelson S.D. Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6. Chemical Research in Toxicology 1998, 11(4):295-301.
5. Coppin J.P., Xu Y., Chen H., Pan M.-H., Ho C.-T., Juliani R., Simon J.E., Wu Q. Determination of flavonoids by LC/MS and anti-inflammatory activity in Moringa oleifera. Journal of Functional Foods 2013, 5(4):1892-1899.
6. Dahlin D.C., Miwa G.T., Lu A.Y., Nelson S.D. N-acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen. Proceedings of the National Academy of Sciences of the United States of America 1984, 81(5):1327-1331.
7. Das N., Sikder K., Ghosh S., Fromenty B., Dey S. Moringa oleifera Lam. leaf extract prevents early liver injury and restores antioxidant status in mice fed with high-fat diet. Indian Journal of Experimental Biology 2012, 50(6):404-412.
8. Dawson A.H., Henry D.A., McEwen J. Adverse reactions to N-acetylcysteine during treatment for paracetamol poisoning. The Medical Journal of Australia 1989, 150(6):329-331.
9. Delanty N., Fitzgerald D.J. Paracetamol poisoning: The action line and the timing of acetylcysteine therapy. Irish Medical Journal 1996, 89(5):156-158.
10. Ezuruike U.F., Prieto J.M. The use of plants in the traditional management of diabetes in Nigeria: Pharmacological and toxicological considerations. Journal of Ethnopharmacology 2014, 155(2):857-924.
11. Fakurazi S., Hairuszah I., Nanthini U. Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 2008, 46(8):2611-2615.
12. FDA Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement - Recommendation to Discontinue Prescribing and Dispensing. U.S. Food and Drug Administration Accessed 23.11.14. http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm381650.htm.
13. Fontana R.J. Acute liver failure including acetaminophen overdose. The Medical Clinics of North America 2008, 92(4):761-794.
14. Goldring C.E., Kitteringham N.R., Elsby R., Randle L.E., Clement Y.N., Williams D.P., Park B.K. Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice. Hepatology (Baltimore, Md.) 2004, 39(5):1267-1276.
15. Gum S.I., Cho M.K. Recent updates on acetaminophen hepatotoxicity: The role of Nrf2 in hepatoprotection. Toxicological Research 2013, 29(3):165-172.
16. Jaeschke H. Role of inflammation in the mechanism of acetaminophen-induced hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 2005, 1(3):389-397.
17. James L.P., Mayeux P.R., Hinson J.A. Acetaminophen-induced hepatotoxicity. Drug Metabolism and Disposition: The Biological Fate of Chemicals 2003, 31(12):1499-1506.
18. Kalsi S.S., Wood D.M., Waring W.S., Dargan P.I. Does cytochrome P450 liver isoenzyme induction increase the risk of liver toxicity after paracetamol overdose?. Open Access Emergency Medicine 2011, 3:69-76.
19. Kalyanaraman B. Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. Redox Biology 2013, 1(1):244-257.
20. Kanter M.Z. Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. American Journal of Health-System Pharmacy 2006, 63(19):1821-1827.
21. Karthivashan G., Arulselvan P., Alimon A.R., Safinar Ismail I., Fakurazi S. Competing role of bioactive constituents in Moringa oleifera extract and conventional nutrition feed on the performance of Cobb 500 broilers. BioMed Research International 2015, 2015. 13.
22. Karthivashan G., Tangestani Fard M., Arulselvan P., Abas F., Fakurazi S. Identification of bioactive candidate compounds responsible for oxidative challenge from hydro-ethanolic extract of Moringa oleifera leaves. Journal of Food Science 2013, 78(9):C1368-C1375.
23. Klaassen C.D., Reisman S.A. Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver. Toxicology and Applied Pharmacology 2010, 244(1):57-65.
24. Lee B.-H., Pan T.-M. Dimerumic acid, a novel antioxidant identified from Monascus-fermented products exerts chemoprotective effects: Mini review. Journal of Functional Foods 2013, 5(1):2-9.
25. Liu Z.X., Govindarajan S., Kaplowitz N. Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity. Gastroenterology 2004, 127(6):1760-1774.
26. Liu Z.X., Han D., Gunawan B., Kaplowitz N. Neutrophil depletion protects against murine acetaminophen hepatotoxicity. Hepatology (Baltimore, Md.) 2006, 43(6):1220-1230.
27. Lynch T., Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. American Academy of Family Physicians 2007, 76(3):391-396.
28. Mandery K., Bujok K., Schmidt I., Keiser M., Siegmund W., Balk B., Glaeser H. Influence of the flavonoids apigenin, kaempferol, and quercetin on the function of organic anion transporting polypeptides 1A2 and 2B1. Biochemical Pharmacology 2010, 80(11):1746-1753.
29. Nelson S.D. Molecular mechanisms of the hepatotoxicity caused by Acetaminophen. Seminars in Liver Disease 1990, 10(4):267-278.
30. Ozer J., Ratner M., Shaw M., Bailey W., Schomaker S. The current state of serum biomarkers of hepatotoxicity. Toxicology 2008, 245(3):194-205.
31. Priyadarsini R.V., Nagini S. Quercetin suppresses cytochrome P450 mediated ROS generation and NFkappaB activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas. Free Radical Research 2012, 46(1):41-49.
32. Reisman S.A., Csanaky I.L., Aleksunes L.M., Klaassen C.D. Altered disposition of acetaminophen in Nrf2-null and Keap1-knockdown mice. Toxicological Sciences 2009, 109(1):31-40.
33. Saw C.L., Guo Y., Yang A.Y., Paredes-Gonzalez X., Ramirez C., Pung D., Kong A.N. The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway. Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association 2014, 72:303-311.
34. Schwabe R.F., Seki E., Brenner D.A. Toll-like receptor signaling in the liver. Gastroenterology 2006, 130(6):1886-1900.
35. Sharifudin S.A., Fakurazi S., Hidayat M.T., Hairuszah I., Aris Mohd Moklas M., Arulselvan P. Therapeutic potential of Moringa oleifera extracts against acetaminophen-induced hepatotoxicity in rats. Pharmaceutical Biology 2012, 51(3):279-288.
36. Shayiq R.M., Roberts D.W., Rothstein K., Snawder J.E., Benson W., Ma X., Black M. Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: An explanation for high acetaminophen dosage in humans without hepatic injury. Hepatology (Baltimore, Md.) 1999, 29(2):451-463.
37. Siddhuraju P., Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. Journal of Agricultural and Food Chemistry 2003, 51(8):2144-2155.
38. Song E., Fu J., Xia X., Su C., Song Y. Bazhen decoction protects against acetaminophen induced acute liver injury by inhibiting oxidative stress, inflammation and apoptosis in mice. PLoS ONE 2014, 9(9):e107405.
39. Tonge R.P., Kelly E.J., Bruschi S.A., Kalhorn T., Eaton D.L., Nebert D.W., Nelson S.D. Role of CYP1A2 in the hepatotoxicity of acetaminophen: Investigations using Cyp1a2 null mice. Toxicology and Applied Pharmacology 1998, 153(1):102-108.
40. Yang Y., Wong S.E., Lightstone F.C. Understanding a substrate's product regioselectivity in a family of enzymes: A case study of acetaminophen binding in cytochrome P450s. PLoS ONE 2014, 9(2):e87058.
41. Yao H.-T., Luo M.-N., Li C.-C. Chitosan oligosaccharides reduce acetaminophen-induced hepatotoxicity by suppressing CYP-mediated bioactivation. Journal of Functional Foods 2015, 12:262-270.
42. Yin H., Xu L., Porter N.A. Free radical lipid peroxidation: Mechanisms and analysis. Chemical Reviews 2011, 111(10):5944-5972.
43. Zaher H., Buters J.T., Ward J.M., Bruno M.K., Lucas A.M., Stern S.T., Gonzalez F.J. Protection against acetaminophen toxicity in CYP1A2 and CYP2E1 double-null mice. Toxicology and Applied Pharmacology 1998, 152(1):193-199.