Quercetin suppresses cytochrome P450 mediated ROS generation and NFκB activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas

Free Radical Research

Volumn 46, Issue 1, 2012, Pages 41-49

  Priyadarsini, Ramamurthi Vidya ^a   Nagini, Siddavaram ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Antioxidants; CYP; NF B; Quercetin; ROS

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; QUERCETIN; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BUCCAL POUCH CARCINOMA; CANCER INHIBITION; CELL DAMAGE; CELL PROLIFERATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DOWN REGULATION; GENE TRANSLOCATION; MALE; MOUTH CARCINOMA; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SYRIAN HAMSTER; TRANSACTIVATION; UPREGULATION;

EID: 83055169869     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2011.637204     Document Type: Article

References (42)

1. Lau AT, Wang Y, Chiu JF. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem 2008;104:657-667. (Pubitemid 351671652)
2. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 2007;39: 44-84. (Pubitemid 44566469)
3. Hrycay EG, Bandiera SM. Expression, function and regulation of mouse cytochrome P450 enzymes: comparison with human P450 enzymes. Curr Drug Metab 2009;10:1151-1183.
4. Klaunig JE, Wang Z, Pu X, Zhou S. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol Appl Pharmacol 2011;254:86-99.
5. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2009;27:120-139.
6. Kostyuk VA, Potapovich AI. Mechanisms of the suppression of free radical overproduction by antioxidants. Front Biosci 2009;1:179-188.
7. Valko M, Rhode CJ, Moncol J, Izakovic M, Mazur M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 2006;160:1-40. (Pubitemid 43227479)
8. Morgan MJ, Liu ZG. Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res 2011;21:103-115.
9. Chaturvedi MM, Sung B, Yadav VR, Kannappan R, Aggarwal BB. NF-kB addiction and its role in cancer: ' one size does not fi t all ' . Oncogene 2011;30:1615-1630.
10. Firuzi O, Miri R, Tavakkoli M, Saso L. Antioxidant therapy: current status and future prospects. Curr Med Chem 2011; 18:3871-3888.
11. Nishiumi S, Miyamoto S, Kawabata K, Ohnishi K, Mukai R, Murakami A, Ashida H, Terao J. Dietary fl avonoids as cancerpreventive and therapeutic biofactors. Front Biosci 2011;3: 1332-1362.
12. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol 2008;585: 325-337.
13. Murakami A, Ashida H, Terao J. Multitargeted cancer prevention by quercetin. Cancer Lett 2008;269:315-325.
14. Vidya Priyadarsini R, Nagini S. Aberrant signaling pathways in cancer: Modulation by the dietary fl avonoid, quercetin. In: Shankar S, Srivastava R, editors. Nutrition, diet and cancer. Dordrecht: Springer (in press).
15. Priyadarsini RV, Vinothini G, Murugan RS, Manikandan P, Nagini S. The fl avonoid quercetin modulates the hallmark capabilities of hamster buccal pouch tumors. Nutr Cancer 2011;63:218-226.
16. Shklar G. Development of experimental oral carcinogenesis and its impact on current oral cancer research. J Dent Res 1999;78:1768-1772. (Pubitemid 32501235)
17. Devipriya S, Ganapathy V, Shyamaladevi CS. Suppression of tumor growth and invasion in 9,10 dimethyl benz(a) anthracene induced mammary carcinoma by the plant biofl avonoid quercetin. Chem Biol Interact 2006;162:106-113. (Pubitemid 44189958)
18. Ames BN, Durston WE, Yamasaki E, Lee FD. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 1973;70:2081-2285.
19. Omura T, Sato R. The carbon monoxide binding pigment of liver. J Biol Chem 1964;239:2370-2378.
20. Burke MD, Thompson S, Elcombe CR, Halpert J, Haparata T, Mayer RT. Ethoxy-, pentoxy-and benzyloxy phenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P450. Biochem Pharmacol 1985;34:3337-3345. (Pubitemid 16215699)
21. Oberley LW, Spitz DR. Assay of superoxide dismutase activity in tumour tissue. Methods Enzymol 1984;105:457-464. (Pubitemid 14165412)
22. Sinha AK. Colorimetric assay of catalase. Anal Biochem 1972;47:389-394.
23. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein-dye binding. Anal Biochem 1976;72:248-254.
24. Nagini S, Vidjaya Letchoumy P, Thangavelu A, Ramachandran CR. Of humans and hamsters: a comparative evaluation of carcinogen activation, DNA damage, cell proliferation, apoptosis, invasion, and angiogenesis in oral cancer patients and hamster buccal pouch carcinomas. Oral Oncol 2009;45: e31-e37.
25. Miyamoto S, Yasui Y, Ohigashi H, Tanaka T, Murakami A. Dietary fl avonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice. Chem Biol Interact 2010;183:276-283.
26. Warren CA, Paulhill KJ, Davidson LA, Lupton JR, Taddeo SS, Hong MY, et al. Quercetin may suppress rat aberrant crypt foci formation by suppressing infl ammatory mediators that infl uence proliferation and apoptosis. J Nutr 2009;139:101-105.
27. Oi N, Hashimoto T, Kanazawa K. Metabolic conversion of dietary quercetin from its conjugate to active aglycone following the induction of hepatocarcinogenesis in Fisher 344 rats. J Agric Food Chem 2008;56:577-583. (Pubitemid 351212588)
28. Kamaraj S, Vinodhkumar R, Anandakumar P, Jagan S, Ramakrishnan G, Devaki T. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol Pharm Bull 2007;30:2268-2273. (Pubitemid 350223724)
29. Jin NZ, Zhu YP, Zhou JW, Mao L, Zhao RC, Fang TH, Wang XR. Preventive effects of quercetin against benzo[a] pyrene-induced DNA damages and pulmonary precancerous pathologic changes in mice. Basic Clin Pharmacol Toxicol 2006;98:593-598.
30. Dihal AA, de Boer VC, van der Woude H, Tilburgs C, Bruijntjes JP, Alink GM, et al. Quercetin, but not its glycosidated conjugate rutin, inhibits azoxymethane-induced colorectal carcinogenesis in F344 rats. J Nutr 2006;136:2862-2867. (Pubitemid 44771787)
31. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. Comparative CYP1A1 and CYP1B1 substrate and inhibitor profi le of dietary fl avonoids. Bioorg Med Chem 2011;19:2842-2849.
32. Guengerich FP. Metabolism of chemical carcinogens. Carcinogenesis 2000;21:345-351. (Pubitemid 30137919)
33. Kang ZC, Tsai SJ, Lee H. Quercetin inhibits benzo[a]pyreneinduced DNA adducts in human HepG2 cells by altering cytochrome P-450 1A1 gene expression. Nutr Cancer 1999;35:175-179. (Pubitemid 30115129)
34. Kanazawa K, Uehara M, Yanagitani H, Hashimoto T. Bioavailable fl avonoids to suppress the formation of 8-OHdG in HepG2 cells. Arch Biochem Biophys 2006;455:197-203. (Pubitemid 44708840)
35. Barcelos GR, Angeli JP, Serpeloni JM, Grotto D, Rocha BA, Bastos JK, et al. Quercetin protects human-derived liver cells against mercury-induced DNA-damage and alterations of the redox status. Mutat Res 2011;726:109-115.
36. Gutteridge JMC, Halliwell B. Antioxidants: molecules, medicines and myths. Biochem Biophys Res Commun 2010;393: 561-564.
37. Vásquez-Garzón VR, Arellanes-Robledo J, García-Román R, Aparicio-Rautista DI, Villa-Trevi ñ o S. Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism. Free Radic Res 2009; 43:128-137.
38. Lin X, Li Q, Wang YJ, Ju YW, Chi ZQ, Wang MW, Liu JG. Morphine inhibits doxorubicin-induced reactive oxygen species generation and nuclear factor kappaB transcriptional activation in neuroblastoma SH-SY5Y cells. Biochem J 2007;406:215-221. (Pubitemid 47310952)
39. Moon DO, Kim MO, Lee JD, Choi YH, Kim GY. Rosmarinic acid sensitizes cell death through suppression of TNF-alphainduced NF-kappaB activation and ROS generation in human leukemia U937 cells. Cancer Lett 2010;288:183-191.
40. Jin Y, Lu Z, Ding K, Li J, Du X, Chen C, et al. Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-kappaB pathway and generation of reactive oxygen species. Cancer Res 2010;70: 2516-2527.
41. Rosemary Siafakas A, Richardson DR. Growth arrest and DNA damage-45 alpha (GADD45alpha). Int J Biochem Cell Biol 2009;41:986-989.
42. Altieri DC. Survivin and IAP proteins in cell-death mechanisms. Biochem J 2010;430:199-205.