Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing

Journal of Receptors and Signal Transduction

Volumn 30, Issue 3, 2010, Pages 143-153

  Okajima, Daisuke ^a   Kudo, Gen ^a   Yokota, Hiroshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

BAI2; GPCR; GPS; Proteolysis

Indexed keywords

ANGIOGENESIS INHIBITOR; BRAIN SPECIFIC ANGIOGENESIS INHIBITOR 2; G PROTEIN COUPLED RECEPTOR; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL LINE, TUMOR; FURIN; HETEROZYGOTE; HIPPOCAMPUS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; NERVE TISSUE PROTEINS; NFATC TRANSCRIPTION FACTORS; PLASMIDS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED;

EID: 77951639349     PISSN: 10799893     EISSN: 15324281     Source Type: Journal    
DOI: 10.3109/10799891003671139     Document Type: Article

References (24)

1. Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. Te human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics 2004, 84, 23-33.
2. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specifc angiogenesis inhibitor 1 (BAI1). Cytogenet Cell Genet 1997, 79, 103-108. (Pubitemid 28107827)
3. Kee HJ, Koh J T, Kim MY, Ahn KY, Kim JK, Bae CS, Park SS, Kim KK. Expression of brain-specifc angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab 2002, 22, 1054-1067.
4. Jeong BC, Kim MY, Lee JH, Kee HJ, Kho DH, Han KE, Qian YR, Kim JK, Kim KK. Brain-specifc angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. FEBS Lett 2006, 580, 669-676.
5. Lagerström MC, Schiöth HB. Structural diversity of G protein-coupled receptors and signifcance for drug discovery. Nat Rev Drug Discov 2008, 7, 339-357.
6. Yona S, Lin HH, Siu WO, Gordon S, Stacey M. Adhesion-GPCRs: emerging roles for novel receptors. Trends Biochem Sci 2008, 33, 491-500.
7. Stacey M, Chang GW, Davies JQ, Kwakkenbos MJ, Sanderson RD, Hamann J, Gordon S, Lin HH. Te epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Blood 2003, 102, 2916-2924. (Pubitemid 37248865)
8. Hamann J, Vogel B, van Schijndel GM, van Lier RA. Te seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J Exp Med 1996, 184, 1185-1189. (Pubitemid 26313577)
9. Iguchi T, Sakata K, Yoshizaki K, Tago K, Mizuno N, Itoh H. Orphan G protein-coupled receptor GPR56 regulates neural progenitor cell migration via a G alpha 12/13 and Rho pathway. J Biol Chem 2008, 283, 14469-14478.
10. Koh JT, Kook H, Kee HJ, Seo YW, Jeong BC, Lee JH, Kim MY, Yoon KC, Jung S, Kim KK. Extracellular fragment of brain-specifc ang-iogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. Exp Cell Res 2004, 294, 172-184. (Pubitemid 38232664)
11. Park D, Tosello-Trampont AC, Elliott MR, Lu M, Haney LB, Ma Z, Klibanov AL, Mandell JW, Ravichandran KS. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature 2007, 450, 430-434. (Pubitemid 350126756)
12. Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y. Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. Biochem Biophys Res Commun 1998, 251, 158-165. (Pubitemid 28498080)
13. Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene 2004, 23, 3889-3897. (Pubitemid 38747917)
14. Abe J, Fukuzawa T, Hirose S. Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site. J Biol Chem 2002, 277, 23391-23398. (Pubitemid 34952170)
15. Krasnoperov V, Lu Y, Buryanovsky L, Neubert TA, Ichtchenko K, Petrenko AG. Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif. J Biol Chem 2002, 277, 46518-46526. (Pubitemid 35417649)
16. Moriguchi T, Haraguchi K, Ueda N, Okada M, Furuya T, Akiyama T. DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites. Genes Cells 2004, 9, 549-560. (Pubitemid 38877784)
17. Koller KJ, Whitehorn EA, Tate E, Ries T, Aguilar B, Chernov-Rogan T, Davis AM, Dobbs A, Yen M, Barrett RW. A generic method for the production of cell lines expressing high levels of 7-transmem-brane receptors. Anal Biochem 1997, 250, 51-60. (Pubitemid 27310313)
18. Brandish PE, Hill LA, Zheng W, Scolnick EM. Scintillation proximity assay of inositol phosphates in cell extracts: high-throughput measurement of G-protein-coupled receptor activation. Anal Biochem 2003, 313, 311-318. (Pubitemid 36259956)
19. Tomas G. Furin at the cutting edge: from protein trafc to embryogenesis and disease. Nat Rev Mol Cell Biol 2002, 3, 753-766.
20. Zhang M, Tong KP, Fremont V, Chen J, Narayan P, Puett D, Weintraub BD, Szkudlinski MW. Te extracellular domain suppresses constitutive activity of the transmembrane domain of the human TSH receptor: implications for hormone-receptor interaction and antagonist design. Endocrinology 2000, 141, 3514-3517. (Pubitemid 32269043)
21. Lin HH, Chang GW, Davies JQ, Stacey M, Harris J, Gordon S. Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. J Biol Chem 2004, 279, 31823-31832. (Pubitemid 39037855)
22. Chen H, Herndon ME, Lawler J. Te cell biology of thrombospon-din-1. Matrix Biol 2000, 19, 597-614.
23. Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, Yoshida S, Ono M, Kuwano M, Nakamura Y, Tokino T. A novel brain-specifc p53-target gene, BAI1, containing thrombospon-din type 1 repeats inhibits experimental angiogenesis. Oncogene 1997, 15, 2145-2150. (Pubitemid 27493903)
24. Kaur B, Brat DJ, Devi NS, Van Meir EG. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Oncogene 2005, 24, 3632-3642. (Pubitemid 40756232)