Secretory diarrhoea: Mechanisms and emerging therapies

Nature Reviews Gastroenterology and Hepatology

Volumn 12, Issue 8, 2015, Pages 446-457

  Thiagarajah, Jay R ^a   Donowitz, Mark ^b   Verkman, Alan S ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETORPHAN; ACETYLSALICYLIC ACID; ALOSETRON; ANTIDIARRHEAL AGENT; BENZOPYRIMIDOPYRROLOOXAZINEDIONE; BUMETANIDE; CALCIUM ACTIVATED CHLORIDE CHANNEL; CALCIUM ION; CHLORIDE CHANNEL BLOCKING AGENT; CLOTRIMAZOLE; CROFELEMER; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR INHIBITOR 172; DIPHENOXYLATE; ELUXADOLINE; GLYCINE HYDRAZIDE 101; IOWH 032; LACTOBACILLUS REUTERI PROBIOTIC AGENT; LOPERAMIDE; LX 1033; ORAL REHYDRATION SOLUTION; OXYGENASE INHIBITOR; PLACEBO; PROBIOTIC AGENT; PYRIMIDOPYRROLOQUINOXALINEDIONE; SODIUM ION; TANNIN; TECALCET; TRYPTOPHAN HYDROXYLASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; CALCIUM SENSING RECEPTOR; CASR PROTEIN, HUMAN; CHLORIDE CHANNEL; CLCA1 PROTEIN, HUMAN; LYSOPHOSPHOLIPID; POTASSIUM CHANNEL BLOCKING AGENT; SLC12A2 PROTEIN, HUMAN; SODIUM POTASSIUM CHLORIDE COTRANSPORTER 1; SODIUM PROTON EXCHANGE PROTEIN; SODIUM-HYDROGEN EXCHANGER 3;

ANTIBIOTIC ASSOCIATED DIARRHEA; ANTIDIARRHEAL ACTIVITY; BACTERIAL INFECTION; CALCIUM SIGNALING; CELIAC DISEASE; CHOLERA; CONGENITAL DIARRHEA; CONTROLLED CLINICAL TRIAL (TOPIC); DIARRHEA; DRUG APPROVAL; DRUG TARGETING; ENTEROTOXIGENIC ESCHERICHIA COLI; ESCHERICHIA COLI INFECTION; GENE MUTATION; HUMAN; IC50; IMMUNOPATHOLOGY; INFECTIOUS DIARRHEA; INFLAMMATORY BOWEL DISEASE; INFLAMMATORY DIARRHEA; INTESTINE MOTILITY; NONHUMAN; ORAL REHYDRATION THERAPY; PATHOPHYSIOLOGY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; ROTAVIRUS INFECTION; SALMONELLOSIS; SECRETION (PROCESS); SECRETORY DIARRHEA; SHIGELLOSIS; SIGNAL TRANSDUCTION; SODIUM ABSORPTION; SODIUM TRANSPORT; VIRUS INFECTION; AGONISTS; ANTAGONISTS AND INHIBITORS; COMPLICATION; DRUG EFFECTS; GASTROENTERITIS; GASTROINTESTINAL MOTILITY; INTESTINE ABSORPTION; MOLECULARLY TARGETED THERAPY; PHYSIOLOGY; PROCEDURES;

ANTIDIARRHEALS; BACTERIAL INFECTIONS; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DIARRHEA; GASTROENTERITIS; GASTROINTESTINAL MOTILITY; HUMANS; INTESTINAL ABSORPTION; LYSOPHOSPHOLIPIDS; MOLECULAR TARGETED THERAPY; POTASSIUM CHANNEL BLOCKERS; PROBIOTICS; RECEPTORS, CALCIUM-SENSING; SODIUM-HYDROGEN ANTIPORTER; SOLUTE CARRIER FAMILY 12, MEMBER 2; VIRUS DISEASES;

EID: 84938750149     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2015.111     Document Type: Review

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