Myosin 5b loss of function leads to defects in polarized signaling: Implication for microvillus inclusion disease pathogenesis and treatment

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 307, Issue 10, 2014, Pages G992-G1001

  Kravtsov, Dmitri ^a   Mashukova, Anastasia ^b,c   Forteza, Radia ^c   Rodriguez, Maria M ^c   Ameen, Nadia A ^a   Salas, Pedro J ^c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NOVA SOUTHEASTERN UNIVERSITY   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Apical recycling endosome; Atypical protein kinase C; Endothelial polarity; Phosphoinositide dependent protein kinase 1; Small ras like guanosine 3 ,5 monophosphate

Indexed keywords

BX 912; ENZYME INHIBITOR; MYOSIN V; MYOSIN VB; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN KINASE C; UNCLASSIFIED DRUG; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; MYO5B PROTEIN, HUMAN; MYOSIN HEAVY CHAIN; PDPK1 PROTEIN, HUMAN; PKC-3 PROTEIN; PROTEIN KINASE INHIBITOR; WATER;

ARTICLE; CELL POLARITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEPOLARIZATION; ENDOSOME; ENZYME INHIBITION; HUMAN; HUMAN CELL; INTESTINE BRUSH BORDER; INTESTINE CELL; LARGE INTESTINE DISEASE; LOSS OF FUNCTION MUTATION; MICROVILLUS INCLUSION DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; WATER ABSORPTION; ANTAGONISTS AND INHIBITORS; CACO 2 CELL LINE; CASE CONTROL STUDY; DOWN REGULATION; DRUG EFFECTS; GENETIC TRANSFECTION; GENETICS; MALABSORPTION SYNDROMES; METABOLISM; MICROVILLUS; MOLECULARLY TARGETED THERAPY; MUCOLIPIDOSES; MUTATION; PATHOLOGY; PHOSPHORYLATION; PROTEIN TRANSPORT; RNA INTERFERENCE;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; CACO-2 CELLS; CASE-CONTROL STUDIES; CELL POLARITY; DOWN-REGULATION; ENDOSOMES; ENTEROCYTES; HUMANS; MALABSORPTION SYNDROMES; MICROVILLI; MOLECULAR TARGETED THERAPY; MUCOLIPIDOSES; MUTATION; MYOSIN HEAVY CHAINS; MYOSIN TYPE V; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSFECTION; WATER;

EID: 84922394222     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00180.2014     Document Type: Article

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