메뉴 건너뛰기




Volumn 20, Issue 5, 2015, Pages 621-631

Improving the preclinical models for the study of chemotherapy-induced cardiotoxicity: a Position Paper of the Italian Working Group on Drug Cardiotoxicity and Cardioprotection

Author keywords

ACE inhibitors; Beta blockers; Cancer therapy induced cardiac injury; Cardiac stem cells; Cardioprotection; Mitochondria; Neuregulin 1; Oxidative stress; Preclinical models; Statins

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; B RAF KINASE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BEVACIZUMAB; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; EDETIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; LIGAND; NEU DIFFERENTIATION FACTOR; PROBUCOL; PROTEIN TYROSINE KINASE INHIBITOR; RAZOXANE; REACTIVE OXYGEN METABOLITE; SORAFENIB; SUNITINIB; VASCULOTROPIN; CARDIOTONIC AGENT; NRG1 PROTEIN, HUMAN;

EID: 84938679294     PISSN: 13824147     EISSN: 15737322     Source Type: Journal    
DOI: 10.1007/s10741-015-9497-4     Document Type: Article
Times cited : (42)

References (102)
  • 1
    • 0038521374 scopus 로고    scopus 로고
    • Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials
    • COI: 1:CAS:528:DC%2BD3sXkslWrsLs%3D, PID: 12767102
    • Swain SM, Whaley FS, Ewer MS (2003) Congestive heart failure in patients treated with doxorubicin: a retrospective analysis of three trials. Cancer 97:2869–2879
    • (2003) Cancer , vol.97 , pp. 2869-2879
    • Swain, S.M.1    Whaley, F.S.2    Ewer, M.S.3
  • 2
    • 34548533485 scopus 로고    scopus 로고
    • Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
    • COI: 1:CAS:528:DC%2BD2sXhtFanu7zI, PID: 17664460
    • Pinder MC, Duan Z, Goodwin JS, Hortobagyi GN, Giordano SH (2007) Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer. J Clin Oncol 25:3808–3815
    • (2007) J Clin Oncol , vol.25 , pp. 3808-3815
    • Pinder, M.C.1    Duan, Z.2    Goodwin, J.S.3    Hortobagyi, G.N.4    Giordano, S.H.5
  • 3
    • 43849094005 scopus 로고    scopus 로고
    • Cardiotoxicity profile of trastuzumab
    • COI: 1:CAS:528:DC%2BD1cXosFGksLo%3D, PID: 18484781
    • Ewer SM, Ewer MS (2008) Cardiotoxicity profile of trastuzumab. Drug Saf 31:459–467
    • (2008) Drug Saf , vol.31 , pp. 459-467
    • Ewer, S.M.1    Ewer, M.S.2
  • 4
    • 0037007076 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity
    • COI: 1:CAS:528:DC%2BD38XjtlCmtLc%3D, PID: 11927521
    • Sawyer DB, Zuppinger C, Miller TA, Eppenberger HM, Suter TM (2002) Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1beta and anti-erbB2: potential mechanism for trastuzumab-induced cardiotoxicity. Circulation 105:1551–1554
    • (2002) Circulation , vol.105 , pp. 1551-1554
    • Sawyer, D.B.1    Zuppinger, C.2    Miller, T.A.3    Eppenberger, H.M.4    Suter, T.M.5
  • 5
    • 33947128057 scopus 로고    scopus 로고
    • Adriamycin-induced myocardial toxicity: new solutions for an old problem?
    • PID: 16863672
    • Outomuro D, Grana DR, Azzato F, Milei J (2007) Adriamycin-induced myocardial toxicity: new solutions for an old problem? Int J Cardiol 117:6–15
    • (2007) Int J Cardiol , vol.117 , pp. 6-15
    • Outomuro, D.1    Grana, D.R.2    Azzato, F.3    Milei, J.4
  • 6
    • 33644806519 scopus 로고    scopus 로고
    • Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies
    • COI: 1:CAS:528:DC%2BD28XktVGnsg%3D%3D, PID: 16351632
    • Wouters KA, Kremer LC, Miller TL, Herman EH, Lipshultz SE (2005) Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies. Br J Haematol 131:561–578
    • (2005) Br J Haematol , vol.131 , pp. 561-578
    • Wouters, K.A.1    Kremer, L.C.2    Miller, T.L.3    Herman, E.H.4    Lipshultz, S.E.5
  • 7
    • 0025051505 scopus 로고
    • Doxorubicin cardiotoxicity: analysis of prevailing hypotheses
    • COI: 1:CAS:528:DyaK3MXhs12ktA%3D%3D, PID: 2210154
    • Olson RD, Mushlin PS (1990) Doxorubicin cardiotoxicity: analysis of prevailing hypotheses. FASEB J 4:3076–3086
    • (1990) FASEB J , vol.4 , pp. 3076-3086
    • Olson, R.D.1    Mushlin, P.S.2
  • 8
    • 2642566088 scopus 로고    scopus 로고
    • Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity
    • COI: 1:CAS:528:DC%2BD2cXltlKgtb0%3D, PID: 15169927
    • Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56:185–229
    • (2004) Pharmacol Rev , vol.56 , pp. 185-229
    • Minotti, G.1    Menna, P.2    Salvatorelli, E.3    Cairo, G.4    Gianni, L.5
  • 9
    • 34548785032 scopus 로고    scopus 로고
    • Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane
    • COI: 1:CAS:528:DC%2BD2sXhtVCit7jK, PID: 17875725
    • Lyu YL, Kerrigan JE, Lin CP, Azarova AM, Tsai YC, Ban Y et al (2007) Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res 67:8839–8846
    • (2007) Cancer Res , vol.67 , pp. 8839-8846
    • Lyu, Y.L.1    Kerrigan, J.E.2    Lin, C.P.3    Azarova, A.M.4    Tsai, Y.C.5    Ban, Y.6
  • 10
    • 84869209094 scopus 로고    scopus 로고
    • Identification of the molecular basis of doxorubicin-induced cardiotoxicity
    • PID: 23104132
    • Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF et al (2012) Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med 18:1639–1642
    • (2012) Nat Med , vol.18 , pp. 1639-1642
    • Zhang, S.1    Liu, X.2    Bawa-Khalfe, T.3    Lu, L.S.4    Lyu, Y.L.5    Liu, L.F.6
  • 11
    • 77958601786 scopus 로고    scopus 로고
    • Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation
    • PID: 20856801
    • Pointon AV, Walker TM, Phillips KM, Luo J, Riley J, Zhang SD et al (2010) Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation. PLoS One 5:e12733
    • (2010) PLoS One , vol.5 , pp. 12733
    • Pointon, A.V.1    Walker, T.M.2    Phillips, K.M.3    Luo, J.4    Riley, J.5    Zhang, S.D.6
  • 12
    • 34247482333 scopus 로고    scopus 로고
    • Cardiolipin: setting the beat of apoptosis
    • COI: 1:CAS:528:DC%2BD2sXksFamsbk%3D, PID: 17294083
    • Gonzalvez F, Gottlieb E (2007) Cardiolipin: setting the beat of apoptosis. Apoptosis 12:877–885
    • (2007) Apoptosis , vol.12 , pp. 877-885
    • Gonzalvez, F.1    Gottlieb, E.2
  • 13
    • 17144405644 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity
    • COI: 1:CAS:528:DC%2BD2MXislahtbY%3D, PID: 15811867
    • Fisher PW, Salloum F, Das A, Hyder H, Kukreja RC (2005) Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity. Circulation 111:1601–1610
    • (2005) Circulation , vol.111 , pp. 1601-1610
    • Fisher, P.W.1    Salloum, F.2    Das, A.3    Hyder, H.4    Kukreja, R.C.5
  • 14
    • 78649329704 scopus 로고    scopus 로고
    • Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells
    • COI: 1:CAS:528:DC%2BC3cXht12qur%2FM, PID: 20155316
    • Di X, Gennings C, Bear HD, Graham LJ, Sheth CM, White KL Jr et al (2010) Influence of the phosphodiesterase-5 inhibitor, sildenafil, on sensitivity to chemotherapy in breast tumor cells. Breast Cancer Res Treat 124:349–360
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 349-360
    • Di, X.1    Gennings, C.2    Bear, H.D.3    Graham, L.J.4    Sheth, C.M.5    White, K.L.6
  • 15
    • 34250004650 scopus 로고    scopus 로고
    • Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling
    • COI: 1:CAS:528:DC%2BD2sXmt1yntL4%3D, PID: 17400201
    • Penna C, Mancardi D, Rastaldo R, Losano G, Pagliaro P (2007) Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling. Cardiovasc Res 75:168–177
    • (2007) Cardiovasc Res , vol.75 , pp. 168-177
    • Penna, C.1    Mancardi, D.2    Rastaldo, R.3    Losano, G.4    Pagliaro, P.5
  • 16
    • 62649116580 scopus 로고    scopus 로고
    • The role of neuregulin-1 beta/erbb signaling in the heart
    • COI: 1:CAS:528:DC%2BD1MXis1aluro%3D, PID: 18801360
    • Pentassuglia L, Sawyer DB (2009) The role of neuregulin-1 beta/erbb signaling in the heart. Exp Cell Res 315:627–637
    • (2009) Exp Cell Res , vol.315 , pp. 627-637
    • Pentassuglia, L.1    Sawyer, D.B.2
  • 17
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: the complexity of targeted inhibitors
    • COI: 1:CAS:528:DC%2BD2MXjslertb0%3D, PID: 15864276
    • Hynes NE, Lane HA (2005) ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 5:341–354
    • (2005) Nat Rev Cancer , vol.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 18
    • 37049183697 scopus 로고
    • Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • COI: 1:CAS:528:DyaL2sXhtVSht7s%3D, PID: 3798106
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235:177–182
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 19
    • 0035869407 scopus 로고    scopus 로고
    • Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
    • COI: 1:CAS:528:DC%2BD3MXisVGktrc%3D, PID: 11248153
    • Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A et al (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 344:783–792
    • (2001) N Engl J Med , vol.344 , pp. 783-792
    • Slamon, D.J.1    Leyland-Jones, B.2    Shak, S.3    Fuchs, H.4    Paton, V.5    Bajamonde, A.6
  • 20
    • 84876526107 scopus 로고    scopus 로고
    • Cancer drugs and the heart: importance and management
    • COI: 1:CAS:528:DC%2BC3sXmt1Chur4%3D, PID: 22789916
    • Suter TM, Ewer MS (2013) Cancer drugs and the heart: importance and management. Eur Heart J 34:1102–1111
    • (2013) Eur Heart J , vol.34 , pp. 1102-1111
    • Suter, T.M.1    Ewer, M.S.2
  • 21
    • 77957576145 scopus 로고    scopus 로고
    • Troponin I provides insight into cardiotoxicity and the anthracycline-trastuzumab interaction
    • COI: 1:CAS:528:DC%2BC3cXht1eqsb%2FM, PID: 20679626
    • Ewer MS, Ewer SM (2010) Troponin I provides insight into cardiotoxicity and the anthracycline-trastuzumab interaction. J Clin Oncol 28:3901–3904
    • (2010) J Clin Oncol , vol.28 , pp. 3901-3904
    • Ewer, M.S.1    Ewer, S.M.2
  • 22
    • 84872031728 scopus 로고    scopus 로고
    • Neuregulin in cardiovascular development and disease
    • COI: 1:CAS:528:DC%2BC38XhsFGqtrzE, PID: 23104879
    • Odiete O, Hill MF, Sawyer DB (2012) Neuregulin in cardiovascular development and disease. Circ Res 111:1376–1385
    • (2012) Circ Res , vol.111 , pp. 1376-1385
    • Odiete, O.1    Hill, M.F.2    Sawyer, D.B.3
  • 23
    • 84883592712 scopus 로고    scopus 로고
    • Emerging paradigms in cardiomyopathies associated with cancer therapies
    • COI: 1:CAS:528:DC%2BC3sXhtlChs7fO, PID: 23989717
    • Ky B, Vejpongsa P, Yeh ET, Force T, Moslehi JJ (2013) Emerging paradigms in cardiomyopathies associated with cancer therapies. Circ Res 113:754–764
    • (2013) Circ Res , vol.113 , pp. 754-764
    • Ky, B.1    Vejpongsa, P.2    Yeh, E.T.3    Force, T.4    Moslehi, J.J.5
  • 24
    • 67650569135 scopus 로고    scopus 로고
    • Neuregulin-1/erbb4 signaling induces cardiomyocyte proliferation and repair of heart injury
    • COI: 1:CAS:528:DC%2BD1MXhtVSgtrzF, PID: 19632177
    • Bersell K, Arab S, Haring B, Kuhn B (2009) Neuregulin-1/erbb4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138:257–270
    • (2009) Cell , vol.138 , pp. 257-270
    • Bersell, K.1    Arab, S.2    Haring, B.3    Kuhn, B.4
  • 25
    • 34247480545 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
    • COI: 1:CAS:528:DC%2BD2sXksFSiu7w%3D, PID: 17457301
    • Force T, Krause DS, Van Etten RA (2007) Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition. Nat Rev Cancer 7:332–344
    • (2007) Nat Rev Cancer , vol.7 , pp. 332-344
    • Force, T.1    Krause, D.S.2    Van Etten, R.A.3
  • 26
    • 74049164266 scopus 로고    scopus 로고
    • The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy
    • PID: 20056944
    • De Keulenaer GW, Doggen K, Lemmens K (2010) The vulnerability of the heart as a pluricellular paracrine organ: lessons from unexpected triggers of heart failure in targeted ErbB2 anticancer therapy. Circ Res 106:35–46
    • (2010) Circ Res , vol.106 , pp. 35-46
    • De Keulenaer, G.W.1    Doggen, K.2    Lemmens, K.3
  • 27
    • 84856166090 scopus 로고    scopus 로고
    • Detection, monitoring, and management of trastuzumab-induced left ventricular dysfunction: an actual challenge
    • COI: 1:CAS:528:DC%2BC38XhsVamsLo%3D, PID: 22219501
    • Tocchetti CG, Ragone G, Coppola C, Rea D, Piscopo G, Scala S et al (2012) Detection, monitoring, and management of trastuzumab-induced left ventricular dysfunction: an actual challenge. Eur J Heart Fail 14:130–137
    • (2012) Eur J Heart Fail , vol.14 , pp. 130-137
    • Tocchetti, C.G.1    Ragone, G.2    Coppola, C.3    Rea, D.4    Piscopo, G.5    Scala, S.6
  • 28
    • 78650383580 scopus 로고    scopus 로고
    • Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology
    • Eschenhagen T, Force T, Ewer MS, de Keulenaer GW, Suter TM, Anker SD et al (2012) Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 13:1–10
    • (2012) Eur J Heart Fail , vol.13 , pp. 1-10
    • Eschenhagen, T.1    Force, T.2    Ewer, M.S.3    de Keulenaer, G.W.4    Suter, T.M.5    Anker, S.D.6
  • 29
    • 0036099675 scopus 로고    scopus 로고
    • ErbB2 is essential in the prevention of dilated cardiomyopathy
    • COI: 1:CAS:528:DC%2BD38Xjt1Kgtbs%3D, PID: 11984589
    • Crone SA, Zhao YY, Fan L, Gu Y, Minamisawa S, Liu Y et al (2002) ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med 8:459–465
    • (2002) Nat Med , vol.8 , pp. 459-465
    • Crone, S.A.1    Zhao, Y.Y.2    Fan, L.3    Gu, Y.4    Minamisawa, S.5    Liu, Y.6
  • 30
    • 32144448027 scopus 로고    scopus 로고
    • Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment
    • COI: 1:CAS:528:DC%2BD2MXht1Cqs7bP, PID: 16258084
    • Ewer MS, Vooletich MT, Durand JB, Woods ML, Davis JR, Valero V et al (2005) Reversibility of trastuzumab-related cardiotoxicity: new insights based on clinical course and response to medical treatment. J Clin Oncol 23:7820–7826
    • (2005) J Clin Oncol , vol.23 , pp. 7820-7826
    • Ewer, M.S.1    Vooletich, M.T.2    Durand, J.B.3    Woods, M.L.4    Davis, J.R.5    Valero, V.6
  • 31
    • 33750347979 scopus 로고    scopus 로고
    • Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes
    • COI: 1:CAS:528:DC%2BD28XhtFenurrE, PID: 17005195
    • Timolati F, Ott D, Pentassuglia L, Giraud MN, Perriard JC, Suter TM et al (2006) Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes. J Mol Cell Cardiol 41:845–854
    • (2006) J Mol Cell Cardiol , vol.41 , pp. 845-854
    • Timolati, F.1    Ott, D.2    Pentassuglia, L.3    Giraud, M.N.4    Perriard, J.C.5    Suter, T.M.6
  • 32
    • 55949123335 scopus 로고    scopus 로고
    • Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
    • PID: 18838713
    • Schmidinger M, Zielinski CC, Vogl UM, Bojic A, Bojic M, Schukro C et al (2008) Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma. J Clin Oncol 26:5204–5212
    • (2008) J Clin Oncol , vol.26 , pp. 5204-5212
    • Schmidinger, M.1    Zielinski, C.C.2    Vogl, U.M.3    Bojic, A.4    Bojic, M.5    Schukro, C.6
  • 33
    • 84881232071 scopus 로고    scopus 로고
    • Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
    • COI: 1:CAS:528:DC%2BC3sXht1OgtbrE, PID: 23908119
    • Welti J, Loges S, Dimmeler S, Carmeliet P (2013) Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J Clin Invest 123:3190–3200
    • (2013) J Clin Invest , vol.123 , pp. 3190-3200
    • Welti, J.1    Loges, S.2    Dimmeler, S.3    Carmeliet, P.4
  • 34
    • 74049125665 scopus 로고    scopus 로고
    • Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics
    • COI: 1:CAS:528:DC%2BD1MXhs1aqt7nI, PID: 20056943
    • Cheng H, Force T (2010) Molecular mechanisms of cardiovascular toxicity of targeted cancer therapeutics. Circ Res 106:21–34
    • (2010) Circ Res , vol.106 , pp. 21-34
    • Cheng, H.1    Force, T.2
  • 35
    • 84877153703 scopus 로고    scopus 로고
    • The emerging issue of cardiac dysfunction induced by antineoplastic angiogenesis inhibitors
    • COI: 1:CAS:528:DC%2BC3sXmtlequrY%3D, PID: 23325019
    • Tocchetti CG, Gallucci G, Coppola C, Piscopo G, Cipresso C, Maurea C et al (2013) The emerging issue of cardiac dysfunction induced by antineoplastic angiogenesis inhibitors. Eur J Heart Fail 15:482–489
    • (2013) Eur J Heart Fail , vol.15 , pp. 482-489
    • Tocchetti, C.G.1    Gallucci, G.2    Coppola, C.3    Piscopo, G.4    Cipresso, C.5    Maurea, C.6
  • 36
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • COI: 1:STN:280:DyaE38%2FgvVCqsQ%3D%3D, PID: 4938153
    • Folkman J (1971) Tumor angiogenesis: therapeutic implications. N Engl J Med 285:1182–1186
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 37
    • 84866599720 scopus 로고    scopus 로고
    • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO clinical practice guidelines
    • PID: 22997448
    • Curigliano G, Cardinale D, Suter T, Plataniotis G, de Azambuja E, Sandri MT et al (2012) Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO clinical practice guidelines. Ann Oncol 23(Suppl 7):vii155–vii166
    • (2012) Ann Oncol , vol.23 , pp. 155-166
    • Curigliano, G.1    Cardinale, D.2    Suter, T.3    Plataniotis, G.4    de Azambuja, E.5    Sandri, M.T.6
  • 38
    • 84904217242 scopus 로고    scopus 로고
    • Angiogenesis, lymphangiogenesis and clinical implications. Preface
    • PID: 24217613
    • Marone G, Granata F (2014) Angiogenesis, lymphangiogenesis and clinical implications. Preface. Chem Immunol Allergy 99:XI–XII
    • (2014) Chem Immunol Allergy , vol.99
    • Marone, G.1    Granata, F.2
  • 39
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • COI: 1:CAS:528:DC%2BD2cXks1Gjt74%3D, PID: 15175435
    • Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W et al (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335–2342
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3    Cartwright, T.4    Hainsworth, J.5    Heim, W.6
  • 40
    • 20044364346 scopus 로고    scopus 로고
    • Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer
    • COI: 1:CAS:528:DC%2BD2MXitVKitrk%3D, PID: 15681523
    • Miller KD, Chap LI, Holmes FA, Cobleigh MA, Marcom PK, Fehrenbacher L et al (2005) Randomized phase III trial of capecitabine compared with bevacizumab plus capecitabine in patients with previously treated metastatic breast cancer. J Clin Oncol 23:792–799
    • (2005) J Clin Oncol , vol.23 , pp. 792-799
    • Miller, K.D.1    Chap, L.I.2    Holmes, F.A.3    Cobleigh, M.A.4    Marcom, P.K.5    Fehrenbacher, L.6
  • 41
    • 84891809086 scopus 로고    scopus 로고
    • Stable carbon isotope discrimination is under genetic control in the C4 species maize with several genomic regions influencing trait expression
    • Gresset S, Westermeier P, Rademacher S, Ouzunova M, Presterl T, Westhoff P et al (2010) Stable carbon isotope discrimination is under genetic control in the C4 species maize with several genomic regions influencing trait expression. Plant Physiol 164:131–143
    • (2010) Plant Physiol , vol.164 , pp. 131-143
    • Gresset, S.1    Westermeier, P.2    Rademacher, S.3    Ouzunova, M.4    Presterl, T.5    Westhoff, P.6
  • 42
    • 76649094893 scopus 로고    scopus 로고
    • Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress
    • COI: 1:CAS:528:DC%2BC3cXhsVOktL8%3D, PID: 20071776
    • Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL et al (2010) Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress. J Clin Invest 120:472–484
    • (2010) J Clin Invest , vol.120 , pp. 472-484
    • Chintalgattu, V.1    Ai, D.2    Langley, R.R.3    Zhang, J.4    Bankson, J.A.5    Shih, T.L.6
  • 43
    • 36849023013 scopus 로고    scopus 로고
    • Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
    • COI: 1:CAS:528:DC%2BD2sXhsVent7bN, PID: 18083403
    • Chu TF, Rupnick MA, Kerkela R, Dallabrida SM, Zurakowski D, Nguyen L et al (2007) Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet 370:2011–2019
    • (2007) Lancet , vol.370 , pp. 2011-2019
    • Chu, T.F.1    Rupnick, M.A.2    Kerkela, R.3    Dallabrida, S.M.4    Zurakowski, D.5    Nguyen, L.6
  • 44
    • 44649165869 scopus 로고    scopus 로고
    • Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor
    • COI: 1:CAS:528:DC%2BD1cXnsFGju78%3D, PID: 18386829
    • Khakoo AY, Kassiotis CM, Tannir N, Plana JC, Halushka M, Bickford C et al (2008) Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor. Cancer 112:2500–2508
    • (2008) Cancer , vol.112 , pp. 2500-2508
    • Khakoo, A.Y.1    Kassiotis, C.M.2    Tannir, N.3    Plana, J.C.4    Halushka, M.5    Bickford, C.6
  • 45
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • COI: 1:CAS:528:DC%2BD2sXksVGqsw%3D%3D, PID: 17215529
    • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O et al (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356:115–124
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3    Michaelson, M.D.4    Bukowski, R.M.5    Rixe, O.6
  • 46
    • 50849094516 scopus 로고    scopus 로고
    • Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate
    • COI: 1:STN:280:DC%2BD1crivFWmsw%3D%3D, PID: 18436521
    • Telli ML, Witteles RM, Fisher GA, Srinivas S (2008) Cardiotoxicity associated with the cancer therapeutic agent sunitinib malate. Ann Oncol 19:1613–1618
    • (2008) Ann Oncol , vol.19 , pp. 1613-1618
    • Telli, M.L.1    Witteles, R.M.2    Fisher, G.A.3    Srinivas, S.4
  • 47
    • 77958194741 scopus 로고    scopus 로고
    • The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro
    • COI: 1:CAS:528:DC%2BC3cXhtlentLvE, PID: 20832415
    • Hasinoff BB, Patel D (2010) The lack of target specificity of small molecule anticancer kinase inhibitors is correlated with their ability to damage myocytes in vitro. Toxicol Appl Pharmacol 249:132–139
    • (2010) Toxicol Appl Pharmacol , vol.249 , pp. 132-139
    • Hasinoff, B.B.1    Patel, D.2
  • 48
    • 67649871388 scopus 로고    scopus 로고
    • Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle
    • COI: 1:CAS:528:DC%2BD1MXms1Wks78%3D, PID: 19443835
    • Anisimov A, Alitalo A, Korpisalo P, Soronen J, Kaijalainen S, Leppanen VM et al (2009) Activated forms of VEGF-C and VEGF-D provide improved vascular function in skeletal muscle. Circ Res 104:1302–1312
    • (2009) Circ Res , vol.104 , pp. 1302-1312
    • Anisimov, A.1    Alitalo, A.2    Korpisalo, P.3    Soronen, J.4    Kaijalainen, S.5    Leppanen, V.M.6
  • 49
    • 57749180643 scopus 로고    scopus 로고
    • Development of targeted angiogenic medicine
    • COI: 1:CAS:528:DC%2BD1MXitFCms74%3D, PID: 18983480
    • Loges S, Roncal C, Carmeliet P (2009) Development of targeted angiogenic medicine. J Thromb Haemost 7:21–33
    • (2009) J Thromb Haemost , vol.7 , pp. 21-33
    • Loges, S.1    Roncal, C.2    Carmeliet, P.3
  • 50
    • 33646149385 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload
    • COI: 1:CAS:528:DC%2BD28XjsVeksrs%3D, PID: 16567591
    • Izumiya Y, Shiojima I, Sato K, Sawyer DB, Colucci WS, Walsh K (2006) Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension 47:887–893
    • (2006) Hypertension , vol.47 , pp. 887-893
    • Izumiya, Y.1    Shiojima, I.2    Sato, K.3    Sawyer, D.B.4    Colucci, W.S.5    Walsh, K.6
  • 51
    • 33646151155 scopus 로고    scopus 로고
    • Microvascular plasticity and experimental heart failure
    • COI: 1:CAS:528:DC%2BD28Xkt1Ogsrs%3D, PID: 16567590
    • Levy BI (2006) Microvascular plasticity and experimental heart failure. Hypertension 47:827–829
    • (2006) Hypertension , vol.47 , pp. 827-829
    • Levy, B.I.1
  • 52
    • 1042286928 scopus 로고    scopus 로고
    • The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities
    • PID: 12700580
    • De Boer RA, Pinto YM, Van Veldhuisen DJ (2003) The imbalance between oxygen demand and supply as a potential mechanism in the pathophysiology of heart failure: the role of microvascular growth and abnormalities. Microcirculation 10:113–126
    • (2003) Microcirculation , vol.10 , pp. 113-126
    • De Boer, R.A.1    Pinto, Y.M.2    Van Veldhuisen, D.J.3
  • 53
    • 74049092701 scopus 로고    scopus 로고
    • Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase
    • COI: 1:CAS:528:DC%2BD1MXntlemtrY%3D, PID: 20376335
    • Kerkela R, Woulfe KC, Durand JB, Vagnozzi R, Kramer D, Chu TF et al (2009) Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci 2:15–25
    • (2009) Clin Transl Sci , vol.2 , pp. 15-25
    • Kerkela, R.1    Woulfe, K.C.2    Durand, J.B.3    Vagnozzi, R.4    Kramer, D.5    Chu, T.F.6
  • 56
    • 74949138296 scopus 로고    scopus 로고
    • Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function
    • PID: 20038740
    • De Angelis A, Piegari E, Cappetta D, Marino L, Filippelli A, Berrino L et al (2010) Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation 121:276–292
    • (2010) Circulation , vol.121 , pp. 276-292
    • De Angelis, A.1    Piegari, E.2    Cappetta, D.3    Marino, L.4    Filippelli, A.5    Berrino, L.6
  • 57
    • 33745843261 scopus 로고    scopus 로고
    • Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines
    • COI: 1:CAS:528:DC%2BD28XmvV2ltbg%3D, PID: 16823487
    • Fazel S, Cimini M, Chen L, Li S, Angoulvant D, Fedak P et al (2006) Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest 116:1865–1877
    • (2006) J Clin Invest , vol.116 , pp. 1865-1877
    • Fazel, S.1    Cimini, M.2    Chen, L.3    Li, S.4    Angoulvant, D.5    Fedak, P.6
  • 59
    • 80052044499 scopus 로고    scopus 로고
    • van Dalen EC, Caron HN, Dickinson HO, Kremer LC (2008) Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev (2):CD003917
    • van Dalen EC, Caron HN, Dickinson HO, Kremer LC (2008) Cardioprotective interventions for cancer patients receiving anthracyclines. Cochrane Database Syst Rev (2):CD003917. doi:10.1002/14651858.CD003917.pub3
  • 60
    • 80052328841 scopus 로고    scopus 로고
    • Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
    • COI: 1:STN:280:DC%2BC3MjlsVCguw%3D%3D, PID: 21833028
    • Huelsenbeck J, Henninger C, Schad A, Lackner KJ, Kaina B, Fritz G (2011) Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity. Cell Death Dis 2:e190
    • (2011) Cell Death Dis , vol.2 , pp. 190
    • Huelsenbeck, J.1    Henninger, C.2    Schad, A.3    Lackner, K.J.4    Kaina, B.5    Fritz, G.6
  • 61
    • 58349097915 scopus 로고    scopus 로고
    • Pretreatment with statin attenuates the cardiotoxicity of doxorubicin in mice
    • COI: 1:CAS:528:DC%2BD1MXltFSgug%3D%3D, PID: 19147586
    • Riad A, Bien S, Westermann D, Becher PM, Loya K, Landmesser U et al (2009) Pretreatment with statin attenuates the cardiotoxicity of doxorubicin in mice. Cancer Res 69:695–699
    • (2009) Cancer Res , vol.69 , pp. 695-699
    • Riad, A.1    Bien, S.2    Westermann, D.3    Becher, P.M.4    Loya, K.5    Landmesser, U.6
  • 62
    • 84870485453 scopus 로고    scopus 로고
    • Effect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: an observational clinical cohort study
    • COI: 1:CAS:528:DC%2BC38XhvVSmtrfJ, PID: 23141499
    • Seicean S, Seicean A, Plana JC, Budd GT, Marwick TH (2012) Effect of statin therapy on the risk for incident heart failure in patients with breast cancer receiving anthracycline chemotherapy: an observational clinical cohort study. J Am Coll Cardiol 60:2384–2390
    • (2012) J Am Coll Cardiol , vol.60 , pp. 2384-2390
    • Seicean, S.1    Seicean, A.2    Plana, J.C.3    Budd, G.T.4    Marwick, T.H.5
  • 63
    • 84860416553 scopus 로고    scopus 로고
    • Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy
    • PID: 21851890
    • Acar Z, Kale A, Turgut M, Demircan S, Durna K, Demir S et al (2011) Efficiency of atorvastatin in the protection of anthracycline-induced cardiomyopathy. J Am Coll Cardiol 58:988–989
    • (2011) J Am Coll Cardiol , vol.58 , pp. 988-989
    • Acar, Z.1    Kale, A.2    Turgut, M.3    Demircan, S.4    Durna, K.5    Demir, S.6
  • 64
    • 80051494089 scopus 로고    scopus 로고
    • Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms
    • PID: 21810673
    • Scott JM, Khakoo A, Mackey JR, Haykowsky MJ, Douglas PS, Jones LW (2011) Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation 124:642–650
    • (2011) Circulation , vol.124 , pp. 642-650
    • Scott, J.M.1    Khakoo, A.2    Mackey, J.R.3    Haykowsky, M.J.4    Douglas, P.S.5    Jones, L.W.6
  • 65
    • 66149119027 scopus 로고    scopus 로고
    • Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction
    • PID: 19482248
    • Jones LW, Eves ND, Haykowsky M, Freedland SJ, Mackey JR (2009) Exercise intolerance in cancer and the role of exercise therapy to reverse dysfunction. Lancet Oncol 10:598–605
    • (2009) Lancet Oncol , vol.10 , pp. 598-605
    • Jones, L.W.1    Eves, N.D.2    Haykowsky, M.3    Freedland, S.J.4    Mackey, J.R.5
  • 66
    • 3142610921 scopus 로고    scopus 로고
    • Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study
    • COI: 1:CAS:528:DC%2BD2cXls1Wntr0%3D, PID: 15251161
    • Weijl NI, Elsendoorn TJ, Lentjes EG, Hopman GD, Wipkink-Bakker A, Zwinderman AH et al (2004) Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study. Eur J Cancer 40:1713–1723
    • (2004) Eur J Cancer , vol.40 , pp. 1713-1723
    • Weijl, N.I.1    Elsendoorn, T.J.2    Lentjes, E.G.3    Hopman, G.D.4    Wipkink-Bakker, A.5    Zwinderman, A.H.6
  • 67
    • 77956934605 scopus 로고    scopus 로고
    • Role of vitamin and mineral supplementation and aspirin use in cancer survivors
    • COI: 1:CAS:528:DC%2BC3cXht1Kmsb7P, PID: 20697066
    • Giovannucci E, Chan AT (2010) Role of vitamin and mineral supplementation and aspirin use in cancer survivors. J Clin Oncol 28:4081–4085
    • (2010) J Clin Oncol , vol.28 , pp. 4081-4085
    • Giovannucci, E.1    Chan, A.T.2
  • 68
    • 47049088074 scopus 로고    scopus 로고
    • Dietary supplement use in cancer care: help or harm
    • Hardy ML (2008) Dietary supplement use in cancer care: help or harm. Hematol Oncol Clin N Am 22:581–617
    • (2008) Hematol Oncol Clin N Am , vol.22 , pp. 581-617
    • Hardy, M.L.1
  • 69
    • 73549087024 scopus 로고    scopus 로고
    • Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy
    • COI: 1:CAS:528:DC%2BC3cXitlagtrs%3D, PID: 20117401
    • Cardinale D, Colombo A, Lamantia G, Colombo N, Civelli M, De Giacomi G et al (2010) Anthracycline-induced cardiomyopathy: clinical relevance and response to pharmacologic therapy. J Am Coll Cardiol 55:213–220
    • (2010) J Am Coll Cardiol , vol.55 , pp. 213-220
    • Cardinale, D.1    Colombo, A.2    Lamantia, G.3    Colombo, N.4    Civelli, M.5    De Giacomi, G.6
  • 70
    • 0036122744 scopus 로고    scopus 로고
    • Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters
    • COI: 1:CAS:528:DC%2BD38XhslyjsL0%3D, PID: 11928719
    • Okumura K, Jin D, Takai S, Miyazaki M (2002) Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters. Jpn J Pharmacol 88:183–188
    • (2002) Jpn J Pharmacol , vol.88 , pp. 183-188
    • Okumura, K.1    Jin, D.2    Takai, S.3    Miyazaki, M.4
  • 71
    • 0033840876 scopus 로고    scopus 로고
    • Prevention of doxorubicin (adriamycin)-induced cardiomyopathy by simultaneous administration of angiotensin-converting enzyme inhibitor assessed by acoustic densitometry
    • COI: 1:CAS:528:DC%2BD3cXmtVelt7k%3D, PID: 10975594
    • Tokudome T, Mizushige K, Noma T, Manabe K, Murakami K, Tsuji T et al (2000) Prevention of doxorubicin (adriamycin)-induced cardiomyopathy by simultaneous administration of angiotensin-converting enzyme inhibitor assessed by acoustic densitometry. J Cardiovasc Pharmacol 36:361–368
    • (2000) J Cardiovasc Pharmacol , vol.36 , pp. 361-368
    • Tokudome, T.1    Mizushige, K.2    Noma, T.3    Manabe, K.4    Murakami, K.5    Tsuji, T.6
  • 72
    • 4143126680 scopus 로고    scopus 로고
    • Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The task force on ACE-inhibitors of the European Society of Cardiology
    • PID: 15302105
    • Lopez-Sendon J, Swedberg K, McMurray J, Tamargo J, Maggioni AP, Dargie H et al (2004) Expert consensus document on angiotensin converting enzyme inhibitors in cardiovascular disease. The task force on ACE-inhibitors of the European Society of Cardiology. Eur Heart J 25:1454–1470
    • (2004) Eur Heart J , vol.25 , pp. 1454-1470
    • Lopez-Sendon, J.1    Swedberg, K.2    McMurray, J.3    Tamargo, J.4    Maggioni, A.P.5    Dargie, H.6
  • 73
    • 84885473117 scopus 로고    scopus 로고
    • Enalaprilat increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy
    • COI: 1:CAS:528:DC%2BC3sXhtFygtLbJ, PID: 23834779
    • Cernecka H, Ochodnicka-Mackovicova K, Kucerova D, Kmecova J, Nemcekova V, Doka G et al (2013) Enalaprilat increases PPARbeta/delta expression, without influence on PPARalpha and PPARgamma, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy. Eur J Pharmacol 714:472–477
    • (2013) Eur J Pharmacol , vol.714 , pp. 472-477
    • Cernecka, H.1    Ochodnicka-Mackovicova, K.2    Kucerova, D.3    Kmecova, J.4    Nemcekova, V.5    Doka, G.6
  • 74
    • 33744809809 scopus 로고    scopus 로고
    • Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats
    • PID: 16324756
    • Soga M, Kamal FA, Watanabe K, Ma M, Palaniyandi S, Prakash P et al (2006) Effects of angiotensin II receptor blocker (candesartan) in daunorubicin-induced cardiomyopathic rats. Int J Cardiol 110:378–385
    • (2006) Int J Cardiol , vol.110 , pp. 378-385
    • Soga, M.1    Kamal, F.A.2    Watanabe, K.3    Ma, M.4    Palaniyandi, S.5    Prakash, P.6
  • 75
    • 28044442932 scopus 로고    scopus 로고
    • Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone
    • COI: 1:CAS:528:DC%2BD2MXhtlWgt7fM, PID: 16247790
    • Nakamae H, Tsumura K, Terada Y, Nakane T, Nakamae M, Ohta K et al (2005) Notable effects of angiotensin II receptor blocker, valsartan, on acute cardiotoxic changes after standard chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Cancer 104:2492–2498
    • (2005) Cancer , vol.104 , pp. 2492-2498
    • Nakamae, H.1    Tsumura, K.2    Terada, Y.3    Nakane, T.4    Nakamae, M.5    Ohta, K.6
  • 76
    • 79959750226 scopus 로고    scopus 로고
    • Mechanisms and management of doxorubicin cardiotoxicity
    • COI: 1:STN:280:DC%2BC3MjjsVygsw%3D%3D, PID: 21656050
    • Shi Y, Moon M, Dawood S, McManus B, Liu PP (2011) Mechanisms and management of doxorubicin cardiotoxicity. Herz 36:296–305
    • (2011) Herz , vol.36 , pp. 296-305
    • Shi, Y.1    Moon, M.2    Dawood, S.3    McManus, B.4    Liu, P.P.5
  • 77
    • 77954334731 scopus 로고    scopus 로고
    • Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines
    • Bovelli D, Plataniotis G, Roila F (2010) Cardiotoxicity of chemotherapeutic agents and radiotherapy-related heart disease: ESMO clinical practice guidelines. Ann Oncol 21(Suppl 5):v277–v282
    • (2010) Ann Oncol , vol.21Suppl 5 , pp. 277-282
    • Bovelli, D.1    Plataniotis, G.2    Roila, F.3
  • 78
    • 84878821763 scopus 로고    scopus 로고
    • Cardioprotective effect of beta-adrenoceptor blockade in patients with breast cancer undergoing chemotherapy: follow-up study of heart failure
    • COI: 1:CAS:528:DC%2BC3sXhtFSntb3O, PID: 23425978
    • Seicean S, Seicean A, Alan N, Plana JC, Budd GT, Marwick TH (2013) Cardioprotective effect of beta-adrenoceptor blockade in patients with breast cancer undergoing chemotherapy: follow-up study of heart failure. Circ Heart Fail 6:420–426
    • (2013) Circ Heart Fail , vol.6 , pp. 420-426
    • Seicean, S.1    Seicean, A.2    Alan, N.3    Plana, J.C.4    Budd, G.T.5    Marwick, T.H.6
  • 79
    • 84883271396 scopus 로고    scopus 로고
    • Protective effects of nebivolol against anthracycline-induced cardiomyopathy: a randomized control study
    • PID: 22727976
    • Kaya MG, Ozkan M, Gunebakmaz O, Akkaya H, Kaya EG, Akpek M et al (2013) Protective effects of nebivolol against anthracycline-induced cardiomyopathy: a randomized control study. Int J Cardiol 167:2306–2310
    • (2013) Int J Cardiol , vol.167 , pp. 2306-2310
    • Kaya, M.G.1    Ozkan, M.2    Gunebakmaz, O.3    Akkaya, H.4    Kaya, E.G.5    Akpek, M.6
  • 80
    • 84864059254 scopus 로고    scopus 로고
    • Administration of angiotensin-converting enzyme inhibitors and beta-blockers during adjuvant trastuzumab chemotherapy for nonmetastatic breast cancer: marker of risk or cardioprotection in the real world?
    • COI: 1:CAS:528:DC%2BC38XhtlGrtr%2FI, PID: 22673631
    • Oliva S, Cioffi G, Frattini S, Simoncini EL, Faggiano P, Boccardi L et al (2012) Administration of angiotensin-converting enzyme inhibitors and beta-blockers during adjuvant trastuzumab chemotherapy for nonmetastatic breast cancer: marker of risk or cardioprotection in the real world? Oncologist 17:917–924
    • (2012) Oncologist , vol.17 , pp. 917-924
    • Oliva, S.1    Cioffi, G.2    Frattini, S.3    Simoncini, E.L.4    Faggiano, P.5    Boccardi, L.6
  • 81
    • 33845206791 scopus 로고    scopus 로고
    • Protective effects of carvedilol against anthracycline-induced cardiomyopathy
    • COI: 1:CAS:528:DC%2BD28Xht12ks7%2FJ, PID: 17161256
    • Kalay N, Basar E, Ozdogru I, Er O, Cetinkaya Y, Dogan A et al (2006) Protective effects of carvedilol against anthracycline-induced cardiomyopathy. J Am Coll Cardiol 48:2258–2262
    • (2006) J Am Coll Cardiol , vol.48 , pp. 2258-2262
    • Kalay, N.1    Basar, E.2    Ozdogru, I.3    Er, O.4    Cetinkaya, Y.5    Dogan, A.6
  • 82
    • 84878731843 scopus 로고    scopus 로고
    • Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies)
    • COI: 1:CAS:528:DC%2BC3sXovVChsb8%3D, PID: 23583763
    • Bosch X, Rovira M, Sitges M, Domenech A, Ortiz-Perez JT, de Caralt TM et al (2013) Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction in patients with malignant hemopathies: the OVERCOME trial (preventiOn of left Ventricular dysfunction with Enalapril and caRvedilol in patients submitted to intensive ChemOtherapy for the treatment of Malignant hEmopathies). J Am Coll Cardiol 61:2355–2362
    • (2013) J Am Coll Cardiol , vol.61 , pp. 2355-2362
    • Bosch, X.1    Rovira, M.2    Sitges, M.3    Domenech, A.4    Ortiz-Perez, J.T.5    de Caralt, T.M.6
  • 83
    • 84973295628 scopus 로고    scopus 로고
    • Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallel-group, randomized, controlled study with 36-month follow-up
    • Georgakopoulos P, Roussou P, Matsakas E, Karavidas A, Anagnostopoulos N, Marinakis T et al (2012) Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallel-group, randomized, controlled study with 36-month follow-up. Cardiology 123:240–247
    • (2012) Cardiology , vol.123 , pp. 240-247
    • Georgakopoulos, P.1    Roussou, P.2    Matsakas, E.3    Karavidas, A.4    Anagnostopoulos, N.5    Marinakis, T.6
  • 84
    • 55749084393 scopus 로고    scopus 로고
    • Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation
    • COI: 1:CAS:528:DC%2BD1cXht1Sgt77K, PID: 18787115
    • Kim IM, Tilley DG, Chen J, Salazar NC, Whalen EJ, Violin JD et al (2008) Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. Proc Natl Acad Sci USA 105:14555–14560
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14555-14560
    • Kim, I.M.1    Tilley, D.G.2    Chen, J.3    Salazar, N.C.4    Whalen, E.J.5    Violin, J.D.6
  • 85
    • 84873374748 scopus 로고    scopus 로고
    • Cardiotoxic and cardioprotective features of chronic beta-adrenergic signaling
    • COI: 1:CAS:528:DC%2BC3sXhslWgsrs%3D, PID: 23104882
    • Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q et al (2013) Cardiotoxic and cardioprotective features of chronic beta-adrenergic signaling. Circ Res 112:498–509
    • (2013) Circ Res , vol.112 , pp. 498-509
    • Zhang, X.1    Szeto, C.2    Gao, E.3    Tang, M.4    Jin, J.5    Fu, Q.6
  • 86
    • 0037129862 scopus 로고    scopus 로고
    • Carvedilol decreases elevated oxidative stress in human failing myocardium
    • COI: 1:CAS:528:DC%2BD38Xls1aku70%3D, PID: 12070115
    • Nakamura K, Kusano K, Nakamura Y, Kakishita M, Ohta K, Nagase S et al (2002) Carvedilol decreases elevated oxidative stress in human failing myocardium. Circulation 105:2867–2871
    • (2002) Circulation , vol.105 , pp. 2867-2871
    • Nakamura, K.1    Kusano, K.2    Nakamura, Y.3    Kakishita, M.4    Ohta, K.5    Nagase, S.6
  • 87
    • 84870298012 scopus 로고    scopus 로고
    • Rationale and design of the prevention of cardiac dysfunction during an adjuvant breast cancer therapy (PRADA) trial
    • COI: 1:CAS:528:DC%2BC3sXlvVajsg%3D%3D, PID: 23207160
    • Heck SL, Gulati G, Ree AH, Schulz-Menger J, Gravdehaug B, Rosjo H et al (2012) Rationale and design of the prevention of cardiac dysfunction during an adjuvant breast cancer therapy (PRADA) trial. Cardiology 123:240–247
    • (2012) Cardiology , vol.123 , pp. 240-247
    • Heck, S.L.1    Gulati, G.2    Ree, A.H.3    Schulz-Menger, J.4    Gravdehaug, B.5    Rosjo, H.6
  • 88
    • 79960691560 scopus 로고    scopus 로고
    • Rationale and design of the multidisciplinary approach to novel therapies in cardiology oncology research trial (MANTICORE 101-breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI
    • PID: 21794114
    • Pituskin E, Haykowsky M, Mackey JR, Thompson RB, Ezekowitz J, Koshman S et al (2011) Rationale and design of the multidisciplinary approach to novel therapies in cardiology oncology research trial (MANTICORE 101-breast): a randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI. BMC Cancer 11:318
    • (2011) BMC Cancer , vol.11 , pp. 318
    • Pituskin, E.1    Haykowsky, M.2    Mackey, J.R.3    Thompson, R.B.4    Ezekowitz, J.5    Koshman, S.6
  • 89
    • 84874220799 scopus 로고    scopus 로고
    • Doxorubicin cardiotoxicity and cardiac function improvement after stem cell therapy diagnosed by strain echocardiography
    • COI: 1:CAS:528:DC%2BC3sXjsFSis70%3D, PID: 23459697
    • Oliveira MS, Melo MB, Carvalho JL, Melo IM, Lavor MS, Gomes DA et al (2013) Doxorubicin cardiotoxicity and cardiac function improvement after stem cell therapy diagnosed by strain echocardiography. J Cancer Sci Ther 5:52–57
    • (2013) J Cancer Sci Ther , vol.5 , pp. 52-57
    • Oliveira, M.S.1    Melo, M.B.2    Carvalho, J.L.3    Melo, I.M.4    Lavor, M.S.5    Gomes, D.A.6
  • 90
    • 84863337601 scopus 로고    scopus 로고
    • Human umbilical cord mesenchymal stromal cells mitigate chemotherapy-associated tissue injury in a pre-clinical mouse model
    • COI: 1:CAS:528:DC%2BC38XktVymtro%3D, PID: 22242830
    • Di GH, Jiang S, Li FQ, Sun JZ, Wu CT, Hu X et al (2012) Human umbilical cord mesenchymal stromal cells mitigate chemotherapy-associated tissue injury in a pre-clinical mouse model. Cytotherapy 14:412–422
    • (2012) Cytotherapy , vol.14 , pp. 412-422
    • Di, G.H.1    Jiang, S.2    Li, F.Q.3    Sun, J.Z.4    Wu, C.T.5    Hu, X.6
  • 91
    • 84903790697 scopus 로고    scopus 로고
    • Notch-1 mediated cardiac protection following embryonic and induced pluripotent stem cell transplantation in doxorubicin-induced heart failure
    • PID: 24988225
    • Merino H, Singla DK (2014) Notch-1 mediated cardiac protection following embryonic and induced pluripotent stem cell transplantation in doxorubicin-induced heart failure. PLoS One 9:e101024
    • (2014) PLoS One , vol.9 , pp. 101024
    • Merino, H.1    Singla, D.K.2
  • 92
    • 84991239057 scopus 로고    scopus 로고
    • Akt-mTOR pathway inhibits apoptosis and fibrosis in doxorubicin-induced cardiotoxicity following embryonic stem cell transplantation
    • PID: 24594448
    • Singla DK (2014) Akt-mTOR pathway inhibits apoptosis and fibrosis in doxorubicin-induced cardiotoxicity following embryonic stem cell transplantation. Cell Transplant 24(6):1031–1042
    • (2014) Cell Transplant , vol.24 , Issue.6 , pp. 1031-1042
    • Singla, D.K.1
  • 93
    • 84991218839 scopus 로고    scopus 로고
    • Embryonic stem cells and released factors stimulate c-kit/FLK-1 progenitor cells and promote neovascularization in doxorubicin-induced cardiomyopathy
    • PID: 24593859
    • Singla DK, Abdelli LS (2014) Embryonic stem cells and released factors stimulate c-kit/FLK-1 progenitor cells and promote neovascularization in doxorubicin-induced cardiomyopathy. Cell Transplant 24(6):1043–1052
    • (2014) Cell Transplant , vol.24 , Issue.6 , pp. 1043-1052
    • Singla, D.K.1    Abdelli, L.S.2
  • 94
    • 77953120266 scopus 로고    scopus 로고
    • Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair
    • COI: 1:CAS:528:DC%2BC3cXlsFGrsrc%3D, PID: 20393738
    • Madonna R, Rokosh G, De Caterina R, Bolli R (2010) Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair. Basic Res Cardiol 105:443–452
    • (2010) Basic Res Cardiol , vol.105 , pp. 443-452
    • Madonna, R.1    Rokosh, G.2    De Caterina, R.3    Bolli, R.4
  • 95
    • 0031658201 scopus 로고    scopus 로고
    • Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity
    • COI: 1:CAS:528:DyaK1cXmvFWgt74%3D, PID: 9768819
    • Herman EH, Ferrans VJ (1998) Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity. Semin Oncol 25:15–21
    • (1998) Semin Oncol , vol.25 , pp. 15-21
    • Herman, E.H.1    Ferrans, V.J.2
  • 96
    • 33748549313 scopus 로고    scopus 로고
    • The relevance of information generated by in vitro experimental models to clinical doxorubicin cardiotoxicity
    • COI: 1:CAS:528:DC%2BD28XhtFKjtrzF, PID: 16966253
    • Lipshultz SE, Cohen H, Colan SD, Herman EH (2006) The relevance of information generated by in vitro experimental models to clinical doxorubicin cardiotoxicity. Leuk Lymphoma 47:1454–1458
    • (2006) Leuk Lymphoma , vol.47 , pp. 1454-1458
    • Lipshultz, S.E.1    Cohen, H.2    Colan, S.D.3    Herman, E.H.4
  • 97
    • 0017911472 scopus 로고
    • Model systems for cardiotoxic effects of anthracyclines
    • Zbinden G, Bachmann E, Holderegger C (1971) Model systems for cardiotoxic effects of anthracyclines. Antibiot Chemother 1978(23):255–270
    • (1971) Antibiot Chemother , vol.1978 , Issue.23 , pp. 255-270
    • Zbinden, G.1    Bachmann, E.2    Holderegger, C.3
  • 98
    • 33845402341 scopus 로고    scopus 로고
    • Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition
    • COI: 1:CAS:528:DC%2BD28Xht1CqurzI, PID: 17101852
    • Cardinale D, Colombo A, Sandri MT, Lamantia G, Colombo N, Civelli M et al (2006) Prevention of high-dose chemotherapy-induced cardiotoxicity in high-risk patients by angiotensin-converting enzyme inhibition. Circulation 114:2474–2481
    • (2006) Circulation , vol.114 , pp. 2474-2481
    • Cardinale, D.1    Colombo, A.2    Sandri, M.T.3    Lamantia, G.4    Colombo, N.5    Civelli, M.6
  • 100
    • 34447094430 scopus 로고    scopus 로고
    • In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity
    • COI: 1:CAS:528:DC%2BD2sXnslWnu70%3D, PID: 17587482
    • Adamcova M, Simunek T, Kaiserova H, Popelova O, Sterba M, Potacova A et al (2007) In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity. Toxicology 237:218–228
    • (2007) Toxicology , vol.237 , pp. 218-228
    • Adamcova, M.1    Simunek, T.2    Kaiserova, H.3    Popelova, O.4    Sterba, M.5    Potacova, A.6
  • 101
    • 84861596866 scopus 로고    scopus 로고
    • Non-invasive in vivo detection of peripheral limb ischemia improvement in the rat after adipose tissue-derived stromal cell transplantation
    • COI: 1:CAS:528:DC%2BC38Xpsl2rsrw%3D, PID: 22473453
    • Madonna R, Delli Pizzi S, Di Donato L, Mariotti A, Di Carlo L, D’Ugo E et al (2012) Non-invasive in vivo detection of peripheral limb ischemia improvement in the rat after adipose tissue-derived stromal cell transplantation. Circ J 76:1517–1525
    • (2012) Circ J , vol.76 , pp. 1517-1525
    • Madonna, R.1    Delli Pizzi, S.2    Di Donato, L.3    Mariotti, A.4    Di Carlo, L.5    D’Ugo, E.6
  • 102
    • 84899424700 scopus 로고    scopus 로고
    • Transplantation of mesenchymal cells improves peripheral limb ischemia in diabetic rats
    • COI: 1:CAS:528:DC%2BC2cXitFOltr0%3D, PID: 24504870
    • Madonna R, Delli Pizzi S, Tartaro A, De Caterina R (2014) Transplantation of mesenchymal cells improves peripheral limb ischemia in diabetic rats. Mol Biotechnol 56:438–448
    • (2014) Mol Biotechnol , vol.56 , pp. 438-448
    • Madonna, R.1    Delli Pizzi, S.2    Tartaro, A.3    De Caterina, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.