Notch-1 mediated cardiac protection following embryonic and induced pluripotent stem cell transplantation in doxorubicin-induced heart failure

PLoS ONE

Volumn 9, Issue 7, 2014, Pages

  Merino, Hilda ^a   Singla, Dinender K ^a  

^a UNIVERSITY OF CENTRAL FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; DOXORUBICIN; GELATINASE B; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR HES 1; ANTINEOPLASTIC ANTIBIOTIC; NOTCH1 PROTEIN, MOUSE;

ACUTE HEART FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ECHOCARDIOGRAPHY; EMBRYONIC STEM CELL; ENZYME ACTIVITY; FEMALE; FIBROSING ALVEOLITIS; HEART FUNCTION; HEART PROTECTION; MALE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; VASCULAR FIBROSIS; ALLOGRAFT; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; HEART FAILURE; METABOLISM; PATHOPHYSIOLOGY; TRANSPLANTATION; TUMOR CELL LINE;

ALLOGRAFTS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; DOXORUBICIN; EMBRYONIC STEM CELLS; HEART FAILURE; MICE; PLURIPOTENT STEM CELLS; RECEPTOR, NOTCH1; STEM CELL TRANSPLANTATION;

EID: 84903790697     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0101024     Document Type: Article

References (44)

1. De Angelis A, Piegari E, Cappetta D, Marino L, Filippelli A, et al. (2010) Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation 121: 276-292.
2. Hershman DL, McBride RB, Eisenberger A, Tsai WY, Grann VR, et al. (2008) Doxorubicin, cardiac risk factors, and cardiac toxicity in elderly patients with diffuse B-cell non-Hodgkin's lymphoma. J Clin Oncol 26: 3159-3165.
3. Miranda CJ, Makui H, Soares RJ, Bilodeau M, Mui J, et al. (2003) Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. Blood 102: 2574-2580. (Pubitemid 37193598)
4. Singal PK, Iliskovic N (1998) Doxorubicin-induced cardiomyopathy. N Engl J Med 339: 900-905. (Pubitemid 28446849)
5. Swerdlow AJ, Higgins CD, Smith P, Cunningham D, Hancock BW, et al. (2007) Myocardial infarction mortality risk after treatment for Hodgkin disease: a collaborative British cohort study. J Natl Cancer Inst 99: 206-214.
6. Geisberg CA, Sawyer DB (2010) Mechanisms of anthracycline cardiotoxicity and strategies to decrease cardiac damage. Curr Hypertens Rep 12: 404-410.
7. Minotti G, Menna P, Salvatorelli E, Cairo G, Gianni L (2004) Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity. Pharmacol Rev 56: 185-229. (Pubitemid 38720829)
8. Psaltis PJ, Carbone A, Leong DP, Lau DH, Nelson AJ, et al. (2011) Assessment of myocardial fibrosis by endoventricular electromechanical mapping in experimental nonischemic cardiomyopathy. Int J Cardiovasc Imaging 27: 25-37.
9. Horenstein MS, Vander Heide RS, L'Ecuyer TJ (2000) Molecular basis of anthracycline-induced cardiotoxicity and its prevention. Mol Genet Metab 71: 436-444.
10. Kumar D, Lou H, Singal PK (2002) Oxidative stress and apoptosis in heart dysfunction. Herz 27: 662-668. (Pubitemid 35415251)
11. Ludke AR, Al-Shudiefat AA, Dhingra S, Jassal DS, Singal PK (2009) A concise description of cardioprotective strategies in doxorubicin-induced cardiotoxicity. Can J Physiol Pharmacol 87: 756-763.
12. Menna P, Salvatorelli E, Minotti G (2010) Anthracycline degradation in cardiomyocytes: a journey to oxidative survival. Chem Res Toxicol 23: 6-10.
13. Das J, Ghosh J, Manna P, Sil PC (2011) Taurine suppresses doxorubicin-triggered oxidative stress and cardiac apoptosis in rat via up-regulation of PI3-K/Akt and inhibition of p53, p38-JNK. Biochem Pharmacol 81: 891-909.
14. Ichihara S, Yamada Y, Kawai Y, Osawa T, Furuhashi K, et al. (2007) Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity. Biochem Biophys Res Commun 359: 27-33. (Pubitemid 46836667)
15. Li T, Singal PK (2000) Adriamycin-induced early changes in myocardial antioxidant enzymes and their modulation by probucol. Circulation 102: 2105-2110.
16. Gopinath S, Vanamala SK, Gondi CS, Rao JS (2010) Human umbilical cord blood derived stem cells repair doxorubicin-induced pathological cardiac hypertrophy in mice. Biochem Biophys Res Commun 395: 367-372.
17. Agbulut O, Menot ML, Li Z, Marotte F, Paulin D, et al. (2003) Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy. Cardiovasc Res 58: 451-459. (Pubitemid 36570403)
18. Garbade J, Dhein S, Lipinski C, Aupperle H, Arsalan M, et al. (2009) Bone marrow-derived stem cells attenuate impaired contractility and enhance capillary density in a rabbit model of Doxorubicin-induced failing hearts. J Card Surg 24: 591-599.
19. Singla DK, Long X, Glass C, Singla RD, Yan B (2011) Induced pluripotent stem (iPS) cells repair and regenerate infarcted myocardium. Mol Pharm 8: 1573-1581.
20. Singla DK, Lyons GE, Kamp TJ (2007) Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling. Am J Physiol Heart Circ Physiol 293: H1308-1314. (Pubitemid 47254236)
21. Singla DK, Sobel BE (2005) Enhancement by growth factors of cardiac myocyte differentiation from embryonic stem cells: a promising foundation for cardiac regeneration. Biochem Biophys Res Commun 335: 637-642. (Pubitemid 41188248)
22. Hodgson DM, Behfar A, Zingman LV, Kane GC, Perez-Terzic C, et al. (2004) Stable benefit of embryonic stem cell therapy in myocardial infarction. Am J Physiol Heart Circ Physiol 287: H471-479. (Pubitemid 38955274)
23. Singla DK (2009) Embryonic stem cells in cardiac repair and regeneration. Antioxid Redox Signal 11: 1857-1863.
24. Singla DK, Ahmed A, Singla R, Yan B (2012) Embryonic stem cells improve cardiac function in Doxorubicin-induced cardiomyopathy mediated through multiple mechanisms. Cell Transplant 21: 1919-1930.
25. Singla DK, Hacker TA, Ma L, Douglas PS, Sullivan R, et al. (2006) Transplantation of embryonic stem cells into the infarcted mouse heart: formation of multiple cell types. J Mol Cell Cardiol 40: 195-200. (Pubitemid 43012130)
26. Glass C, Singla DK (2011) MicroRNA-1 transfected embryonic stem cells enhance cardiac myocyte differentiation and inhibit apoptosis by modulating the PTEN/Akt pathway in the infarcted heart. Am J Physiol Heart Circ Physiol 301: H2038-2049.
27. Kumar D, Hacker TA, Buck J, Whitesell LF, Kaji EH, et al. (2005) Distinct mouse coronary anatomy and myocardial infarction consequent to ligation. Coron Artery Dis 16: 41-44. (Pubitemid 40279597)
28. Boni A, Urbanek K, Nascimbene A, Hosoda T, Zheng H, et al. (2008) Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A 105: 15529-15534.
29. Gude NA, Emmanuel G, Wu W, Cottage CT, Fischer K, et al. (2008) Activation of Notch-mediated protective signaling in the myocardium. Circ Res 102: 1025-1035. (Pubitemid 351667856)
30. Li Y, Hiroi Y, Ngoy S, Okamoto R, Noma K, et al. (2011) Notch1 in bone marrow-derived cells mediates cardiac repair after myocardial infarction. Circulation 123: 866-876.
31. Oliveira MS, Melo MB, Carvalho JL, Melo IM, Lavor MS, et al. (2013) Doxorubicin Cardiotoxicity and Cardiac Function Improvement After Stem Cell Therapy Diagnosed by Strain Echocardiography. J Cancer Sci Ther 5: 52-57.
32. Singal PK, Iliskovic N, Li T, Kumar D (1997) Adriamycin cardiomyopathy: pathophysiology and prevention. FASEB J 11: 931-936. (Pubitemid 27425894)
33. Singal PK, Li T, Kumar D, Danelisen I, Iliskovic N (2000) Adriamycin-induced heart failure: mechanism and modulation. Mol Cell Biochem 207: 77-86.
34. Collesi C, Zentilin L, Sinagra G, Giacca M (2008) Notch1 signaling stimulates proliferation of immature cardiomyocytes. J Cell Biol 183: 117-128.
35. High FA, Epstein JA (2008) The multifaceted role of Notch in cardiac development and disease. Nat Rev Genet 9: 49-61.
36. Nemir M, Metrich M, Plaisance I, Lepore M, Cruchet S, et al. (2012) The Notch pathway controls fibrotic and regenerative repair in the adult heart. Eur Heart J.
37. Nemir M, Pedrazzini T (2008) Functional role of Notch signaling in the developing and postnatal heart. J Mol Cell Cardiol 45: 495-504.
38. Niessen K, Karsan A (2008) Notch signaling in cardiac development. Circ Res 102: 1169-1181.
39. Wong GW, Knowles GC, Mak TW, Ferrando AA, Zuniga-Pflucker JC (2012) HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRbeta-selected mouse thymocytes. Blood 120: 1439-1448.
40. Gutierrez A, Sanda T, Grebliunaite R, Carracedo A, Salmena L, et al. (2009) High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 114: 647-650.
41. Glass C, Singla DK (2012) Overexpression of TIMP-1 in embryonic stem cells attenuates adverse cardiac remodeling following myocardial infarction. Cell Transplant 21: 1931-1944.
42. Singla DK (2014) Akt-mTOR Pathway Inhibits Apoptosis and Fibrosis in Doxorubicin-Induced Cardiotoxicity Following Embryonic Stem Cell Transplantation. Cell Transplant.
43. Yan B, Singla DK (2013) Transplanted induced pluripotent stem cells mitigate oxidative stress and improve cardiac function through the Akt cell survival pathway in diabetic cardiomyopathy. Mol Pharm 10: 3425-3432.
44. Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, et al. (2007) Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response. FASEB J 21: 1345-1357. (Pubitemid 46684837)