Hepatocyte growth factor/met gene transfer in cardiac stem cells-potential for cardiac repair

Basic Research in Cardiology

Volumn 105, Issue 4, 2010, Pages 443-452

  Madonna, Rosalinda ^b   Rokosh, Gregg ^a   De Caterina, Raffaele ^b   Bolli, Roberto ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

Cardiac progenitor cells; Cardiac repair; Cardiac stem cells; Cell based therapy; Gene therapy; Hepatocyte growth factor

Indexed keywords

ADENOVIRUS VECTOR; CYTOKINE; GROWTH FACTOR; LENTIVIRUS VECTOR; PARVOVIRUS VECTOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN; TYROSINE KINASE RECEPTOR; VASCULOTROPIN;

CELL DIFFERENTIATION; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL TRIAL; CONGESTIVE CARDIOMYOPATHY; DRUG MECHANISM; DRUG MEGADOSE; ENGRAFTMENT; GENE TRANSFER; HEART DISEASE; HEART INFARCTION; HEART MUSCLE CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; STEM CELL; STEM CELL GENE THERAPY; STEM CELL TRANSPLANTATION; TISSUE REGENERATION; VIRAL GENE DELIVERY SYSTEM;

ADULT STEM CELLS; ANIMALS; GENE THERAPY; GENETIC VECTORS; HEART; HEPATOCYTE GROWTH FACTOR; LENTIVIRUS; MYOCARDIUM; PROTO-ONCOGENE PROTEINS C-MET; RECEPTORS, GROWTH FACTOR; REGENERATION; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION;

EID: 77953120266     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-010-0102-7     Document Type: Review

References (75)

1. Abdel-Latif A, Bolli R, Tleyjeh IM, Montori VM, Perin EC, Hornung CA, Zuba-Surma EK, Al-Mallah M, Dawn B (2007) Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med 167:989-997 (Pubitemid 46835786)
2. Abdel-Latif A, Zuba-Surma EK, Case J, Tiwari S, Hunt G, Ranjan S, Vincent RJ, Srour EF, Bolli R, Dawn B (2008) TGF-betal enhances cardiomyogenic differentiation of skeletal muscle-derived adult primitive cells. Basic Res Cardiol 103(6): 514-524
3. Adams DH, Harvath L, Bottaro DP, Interrante R, Catalano G, Tanaka Y, Strain A, Hubscher SG, Shaw S (1994) Hepatocyte growth factor and macrophage inflammatory protein 1 beta: structurally distinct cytokines that induce rapid cytoskeletal changes and subset-preferential migration in T cells. Proc Natl Acad Sci USA 91:7144-7148 (Pubitemid 24226819)
4. Amado LC, Saliaris AP, Schulen KH, St John M, Xie JS, Cattaneo S, Durand DJ, Fitton T, Kuang JQ, Stewart G, Lehrke S, Baumgartner WW, Martin BJ, Heldman AW, Hare JM (2005) Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction. Proc Natl Acad Sci USA 102:11474-11479 (Pubitemid 41153844)
5. Bell LN, Cai L, Johnstone BH, Traktuev DO, March KL, Considine RV (2008) A central role for hepatocyte growth factor in adipose tissue angiogenesis. Am J Physiol Endocrinol Metab 294:E336-E344 (Pubitemid 351231459)
6. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 114:763-776 (Pubitemid 37186770)
7. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF (2003) Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4:915-925
8. Birchmeier C, Gherardi E (1998) Developmental roles of HGF/ SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol 8:404-410 (Pubitemid 28458706)
9. Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA (1991) Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251:802-804 (Pubitemid 21926175)
10. Cai L, Johnstone BH, Cook TG, Tan J, Fishbein MC, Chen PS, March KL (2009) IFATS series: human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells 27(1):230-237
11. Case SS, Price MA, Jordan CT, Yu XJ, Wang L, Bauer G, Haas DL, Xu D, Stripecke R, Naldini L, Kohn DB, Crooks GM (1999) Stable transduction of quiescent CD34(+)CD38(-) human hematopoietic cells by HIV-1-based lentiviral vectors. Proc Natl Acad Sci USA 96:2988-2993 (Pubitemid 29148831)
12. Dawn B, Bolli R (2005) Cardiac progenitor cells: the revolution continues. Circ Res 97:1080-1082 (Pubitemid 43755197)
13. Dawn B, Stein AB, Urbanek K, Rota M, Whang B, Rastaldo R, Torella D, Tang XL, Rezazadeh A, Kajstura J, Leri A, Hunt G, Varma J, Prabhu SD, Anversa P, Bolli R (2005) Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci USA 102:3766-3771 (Pubitemid 40354686)
14. Donsante A, Miller DG, Li Y, Vogler C, Brunt EM, Russell DW, Sands MS (2007) AAV vector integration sites in mouse hepatocellular carcinoma. Science 317:477 (Pubitemid 47196106)
15. Emi N, Friedmann T, Yee JK (1991) Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus. J Virol 65:1202-1207
16. Follenzi A, Santambrogio L, Annoni A (2007) Immune responses to lentiviral vectors. Curr Gene Ther 7:306-315
17. Forte G, Minieri M, Cossa P, Antenucci D, Sala M, Gnocchi V, Fiaccavento R, Carotenuto F, De Vito P, Baldini PM, Prat M, Di Nardo P (2006) Hepatocyte growth factor effects on mesenchymal stem cells: proliferation, migration, and differentiation. Stem Cells 24:23-33
18. Gherardi E, Stoker M (1991) Hepatocyte growth factor-scatter factor: mitogen, motogen, and met. Cancer Cells 3:227-232
19. Graziani A, Gramaglia D, Cantley LC, Comoglio PM (1991) The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J Biol Chem 266:22087-22090 (Pubitemid 21908617)
20. Guan K, Hasenfuss G (2007) Do stem cells in the heart truly differentiate into cardiomyocytes? J Mol Cell Cardiol 43:377-387
21. Guo Y, He J, Wu J, Yang L, Dai S, Tan X, Liang L (2008) Locally overexpressing hepatocyte growth factor prevents postishemic heart failure by inhibition of apoptosis via calcineurinmediated pathway and angiogenesis. Arch Med Res 39:179-188 (Pubitemid 350299629)
22. Halkos ME, Zhao ZQ, Kerendi F, Wang NP, Jiang R, Schmarkey LS, Martin BJ, Quyyumi AA, Few WL, Kin H, Guyton RA, Vinten-Johansen J (2008) Intravenous infusion of mesenchymal stem cells enhances regional perfusion and improves ventricular function in a porcine model of myocardial infarction. Basic Res Cardiol 103(6):525-536
23. Hamasuna R, Kataoka H, Moriyama T, Itoh H, Seiki M, Koono M (1999) Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP. Int J Cancer 82:274-281 (Pubitemid 29293788)
24. Hogan BL, Kolodziej PA (2002) Organogenesis: molecular mechanisms of tubulogenesis. Nat Rev Genet 3:513-523
25. Kajstura J, Rota M, Whang B, Cascapera S, Hosoda T, Bearzi C, Nurzynska D, Kasahara H, Zias E, Bonafe M, Nadal-Ginard B, Torella D, Nascimbene A, Quaini F, Urbanek K, Leri A, Anversa P (2005) Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res 96:127-137 (Pubitemid 40095762)
26. Kaur S, Kumar TR, Uruno A, Sugawara A, Jayakumar K, Kartha CC (2009) Genetic engineering with endothelial nitric oxide synthase improves functional properties of endothelial progenitor cells from patients with coronary artery disease: an in vitro study. Basic Res Cardiol 104(6):739-749
27. Kopp JB (1998) Hepatocyte growth factor: mesenchymal signal for epithelial homeostasis. Kidney Int 54:1392-1393 (Pubitemid 28449933)
28. Kretzschmar M, Doody J, Massague J (1997) Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smadl. Nature 389:618-622 (Pubitemid 27446181)
29. Kuang D, Zhao X, Xiao G, Ni J, Feng Y, Wu R, Wang G (2008) Stem cell factor/c-kit signaling mediated cardiac stem cell migration via activation of p38 MAPK. Basic Res Cardiol 103(3):265-273
30. Lever AM (1996) HIV and other lentivirus-based vectors. Gene Ther 3:470-471
31. Li B, Zeng Q, Wang H, Shao S, Mao X, Zhang F, Li S, Guo Z (2007) Adipose tissue stromal cells transplantation in rats of acute myocardial infarction. Coron Artery Dis 18(3):221-227 (Pubitemid 46608501)
32. Linke A, Muller P, Nurzynska D, Casarsa C, Torella D, Nascimbene A, Castaldo C, Cascapera S, Bohm M, Quaini F, Urbanek K, Leri A, Hintze TH, Kajstura J, Anversa P (2005) Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci USA 102:8966-8971 (Pubitemid 40881062)
33. Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG (2007) Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Curr Gene Ther 7:347-360 (Pubitemid 47595777)
34. Madonna R, Geng YJ, De Caterina R (2009) Adipose tissue-derived stem cells: characterization and potential for cardiovascular repair. Arterioscler Thromb Vase Biol 29(11):1723-1729
35. Marsboom G, Janssens S (2008) Endothelial progenitor cells: new perspectives and applications in cardiovascular therapies. Expert Rev Cardiovasc Ther 6:687-701
36. Mazo M, Planat-Benard V, Abizanda G, Pelacho B, Leobon B, Gavira JJ, Penuelas I, Cemborain A, Penicaud L, Laharrague P, Joffre C, Boisson M, Ecay M, Collantes M, Barba J, Casteilla L, Prosper F (2008) Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail 10:454-462
37. McCall-Culbreath KD, Li Z, Zutter MM (2008) Crosstalk between the alpha2betal integrin and c-met/HGF-R regulates innate immunity. Blood 111:3562-3570
38. Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, Hecker H, Schaefer A, Arseniev L, Hertenstein B, Ganser A, Drexler H (2006) Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation 113:1287-1294 (Pubitemid 43739450)
39. Miyahara Y, Nagaya N, Kataoka M, Yanagawa B, Tanaka K, Hao H, Ishino K, Ishida H, Shimizu T, Kangawa K, Sano S, Okano T, Kitamura S, Mori H (2006) Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med 12:459-465
40. Mizuno S, Kurosawa T, Matsumoto K, Mizuno-Horikawa Y, Okamoto M, Nakamura T (1998) Hepatocyte growth factor prevents renal fibrosis and dysfunction in a mouse model of chronic renal disease. J Clin Invest 101:1827-1834 (Pubitemid 28226100)
41. Monga SP, Mars WM, Pediaditakis P, Bell A, Mule K, Bowen WC, Wang X, Zarnegar R, Michalopoulos GK (2002) Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res 62:2064-2071 (Pubitemid 34408453)
42. Morishita R, Aoki M, Hashiya N, Yamasaki K, Kurinami H, Shimizu S, Makino H, Takesya Y, Azuma J, Ogihara T (2004) Therapeutic angiogenesis using hepatocyte growth factor (HGF). Curr Gene Ther 4:199-206 (Pubitemid 38842622)
43. Neuss S, Becher E, Woltje M, Tietze L, Jahnen-Dechent W (2004) Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells 22:405-414 (Pubitemid 38736624)
44. Oh SH, Miyazaki M, Kouchi H, Inoue Y, Sakaguchi M, Tsuji T, Shima N, Higashio K, Namba M (2000) Hepatocyte growth factor induces differentiation of adult rat bone marrow cells into a hepatocyte lineage in vitro. Biochem Biophys Res Commun 279:500-504 (Pubitemid 32016744)
45. Okunishi K, Dohi M, Nakagome K, Tanaka R, Mizuno S, Matsumoto K, Miyazaki J, Nakamura T, Yamamoto K (2005) A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J Immunol 175: 4745-4753 (Pubitemid 41362016)
46. Perin EC, Dohmann HF, Borojevic R, Silva SA, Sousa AL, Mesquita CT, Rossi MI, Carvalho AC, Dutra HS, Dohmann HJ, Silva GV, Belem L, Vivacqua R, Rangel FO, Esporcatte R, Geng YJ, Vaughn WK, Assad JA, Mesquita ET, Willerson JT (2003) Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107:2294-2302 (Pubitemid 36578498)
47. Pollack AL, Runyan RB, Mostov KE (1998) Morphogenetic mechanisms of epithelial tubulogenesis: MDCK cell polarity is transiently rearranged without loss of cell-cell contact during scatter factor/hepatocyte growth factor-induced tubulogenesis. Dev Biol 204:64-79
48. Rabbany SY, Pastore J, Yamamoto M, Miller T, Rafii S, Aras R, Penn M (2009) Continuous delivery of stromal cell-derived factor-1 from alginate scaffolds accelerates wound healing. Cell Transpl. doi:10.3727/096368909X481782
49. Rappolee DA, Iyer A, Patel Y (1996) Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis. Circ Res 78:1028-1036 (Pubitemid 26166711)
50. Roggia C, Ukena C, Bohm M, Kilter H (2007) Hepatocyte growth factor (HGF) enhances cardiac commitment of differentiating embryonic stem cells by activating PI3 kinase. Exp Cell Res 313:921-930 (Pubitemid 46298560)
51. Rombouts WJ, Ploemacher RE (2003) Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture. Leukemia 17:160-170
52. Rosario M, Birchmeier W (2003) How to make tubes: signaling by the Met receptor tyrosine kinase. Trends Cell Biol 13:328-335 (Pubitemid 36638800)
53. Rose RA, Jiang H, Wang X, Heike S, Tsoporis JN, Gong N, Keating SC, Parker TG, Backx PH, Keating A (2008) Bone marrow-derived mesenchymal stromal cells express cardiacspecific markers, retain the stromal phenotype, and do not become functional cardiomyocytes in vitro. Stem Cells 26:2884-2892
54. Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, Bolli R, Houser SR, Leri A, Sussman MA, Anversa P (2007) Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci USA 104:17783-17788 (Pubitemid 350210912)
55. Schachinger V, Assmus B, Britten MB, Honold J, Lehmann R, Teupe C, Abolmaali ND, Vogl TJ, Hofmann WK, Martin H, Dimmeler S, Zeiher AM (2004) Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol 44:1690-1699 (Pubitemid 39369805)
56. Schenke-Layland K, Strem B, Jordan M, Deemedio M, Hedrick M, Roos K, Fraser J, Maclellan W (2009) Adipose tissue derived cells improve cardiac function following myocardial infarction. J Surg Res 153(2):217-223
57. Schuh A, Liehn EA, Sasse A, Hristov M, Sobota R, Kelm M, Merx MW, Weber C (2008) Transplantation of endothelial progenitor cells improves neovascularization and left ventricular function after myocardial infarction in a rat model. Basic Res Cardiol 103(1):69-77 (Pubitemid 50002796)
58. Shabbir A, Zisa D, Suzuki G, Lee T (2009) Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol 296:H1888-H1897
59. Stamm C, Westphal B, Kleine HD, Petzsch M, Kittner C, Klinge H, Schumichen C, Nienaber CA, Freund M, Steinhoff G (2003) Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361:45-46 (Pubitemid 36050962)
60. Svensson EC, Marshall DJ, Woodard K, Lin H, Jiang F, Chu L, Leiden JM (1999) Efficient and stable transduction of cardiomyocytes after intramyocardial injection or intracoronary perfusion with recombinant adeno-associated virus vectors. Circulation 99:201-205 (Pubitemid 29056359)
61. Ueki T, Kaneda Y, Tsutsui H, Nakanishi K, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Takahashi H, Okamoto E, Fujimoto J (1999) Hepatocyte growth factor gene therapy of liver cirrhosis in rats. Nat Med 5:226-230 (Pubitemid 29068532)
62. Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P (2005) Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 97:663-673 (Pubitemid 41416335)
63. Valina C, Pinkernell K, Song YH, Bai X, Sadat S, Campeau RJ, Le Jemtel TH, Alt E (2007) Intracoronary administration of autologous adipose tissue-derived stem cells improves left ventricular function, perfusion, and remodelling after acute myocardial infarction. Eur Heart J 28:2667-2677 (Pubitemid 350071533)
64. Van't Hof W, Mal N, Huang Y, Zhang M, Popovic Z, Forudi F, Deans R, Penn MS (2007) Direct delivery of syngeneic and allogeneic large-scale expanded multipotent adult progenitor cells improves cardiac function after myocardial infarct. Cytotherapy 9:477-487
65. van der Voort R, Taher TE, Keehnen RM, Smit L, Groenink M, Pals ST (1997) Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. J Exp Med 185:2121-2131 (Pubitemid 27265996)
66. Weidner KM, Arakaki N, Hartmann G, Vandekerckhove J, Weingart S, Rieder H, Fonatsch C, Tsubouchi H, Hishida T, Daikuhara Y et al (1991) Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl Acad Sci USA 88:7001-7005 (Pubitemid 21915077)
67. Weidner KM, Behrens J, Vandekerckhove J, Birchmeier W (1990) Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol 111:2097-2108 (Pubitemid 20361315)
68. Weimar IS, de Jong D, Muller EJ, Nakamura T, van Gorp JM, de Gast GC, Gerritsen WR (1997) Hepatocyte growth factor/scatter factor promotes adhesion of lymphoma cells to extracellular matrix molecules via alpha 4 beta 1 and alpha 5 beta 1 integrins. Blood 89:990-1000
69. Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR (2001) Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 98:247-252 (Pubitemid 32095895)
70. Yamada Y, Wang X, Yokoyama S, Fukuda N, Takakura N (2006) Cardiac progenitor cells in brown adipose tissue repaired damaged myocardium. Biochem Biophys Res Commun 342(2): 662-670 (Pubitemid 43289041)
71. Yamaura K, Ito K, Tsukioka K, Wada Y, Makiuchi A, Sakaguchi M, Akashima T, Fujimori M, Sawa Y, Morishita R, Matsumoto K, Nakamura T, Suzuki J, Amano J, Isobe M (2004) Suppression of acute and chronic rejection by hepatocyte growth factor in a murine model of cardiac transplantation: induction of tolerance and prevention of cardiac allograft vasculopathy. Circulation 110:1650-1657 (Pubitemid 39297989)
72. Zhang D-Z, Gai L-Y, Liu H-W, Jin Q-H, Huang J-H, Zhu X-Y (2007) Transplantation of autologous adipose-derived stem cells ameliorates cardiac function in rabbits with myocardial infarction. Chin Med J 120(4):300-307 (Pubitemid 46403479)
73. Zhang G, Hu Q, Braunlin EA, Suggs LJ, Zhang J (2008) Enhancing efficacy of stem cell transplantation to the heart with a PEGylated fibrin biomatrix. Tissue Eng Part A 14:1025-1036 (Pubitemid 351862226)
74. Zhang J, Wilson GF, Soerens AG, Koonce CH, Yu J, Palecek SP, Thomson JA, Kamp TJ (2009) Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res 104:e30-e41
75. Zhu XY, Zhang XZ, Xu L, Zhong XY, Ding Q, Chen YX (2009) Transplantation of adipose-derived stem cells overexpressing hHGF into cardiac tissue. Biochem Biophys Res Commun 379:1084-1090