Rationale and design of the Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research Trial (MANTICORE 101 - Breast): A randomized, placebo-controlled trial to determine if conventional heart failure pharmacotherapy can prevent trastuzumab-mediated left ventricular remodeling among patients with HER2+ early breast cancer using cardiac MRI

BMC Cancer

Volumn 11, Issue , 2011, Pages

  Pituskin, Edith ^a,b   Haykowsky, Mark ^a   Mackey, John R ^a,b   Thompson, Richard B ^a   Ezekowitz, Justin ^a,c   Koshman, Sheri ^a,c   Oudit, Gavin ^a,c   Chow, Kelvin ^a   Pagano, Joseph J ^a   Paterson, Ian ^a,c  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

^c Department of Cardiology   (Canada)

Author keywords

Breast cancer; Cardiac remodeling; Cardiotoxicity; Heart failure; Trastuzumab

Indexed keywords

BISOPROLOL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PERINDOPRIL; PLACEBO; TRASTUZUMAB; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; MONOCLONAL ANTIBODY;

ADULT; APOPTOSIS; ARTICLE; BREAST CANCER; CARDIOTOXICITY; CARDIOVASCULAR MAGNETIC RESONANCE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EARLY CANCER; EXTRACELLULAR MATRIX; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE REMODELING; HEART MUSCLE INJURY; HUMAN; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PARALLEL DESIGN; PATIENT MONITORING; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; BREAST TUMOR; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; FEMALE; HEART FAILURE; HEART VENTRICLE REMODELING; METABOLISM; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE IMAGING; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ADRENERGIC BETA-1 RECEPTOR ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANTIBODIES, MONOCLONAL, HUMANIZED; APOPTOSIS; BISOPROLOL; BREAST NEOPLASMS; FEMALE; HEART FAILURE; HUMANS; MAGNETIC RESONANCE IMAGING; PERINDOPRIL; PLACEBOS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECEPTOR, ERBB-2; RESEARCH DESIGN; VENTRICULAR REMODELING;

EID: 79960691560     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-318     Document Type: Article

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