Modulation of anthracycline-induced myofibrillar disarray in rat ventricular myocytes by neuregulin-1β and anti-erbB2: Potential mechanism for trastuzumab-induced cardiotoxicity

Circulation

Volumn 105, Issue 13, 2002, Pages 1551-1554

  Sawyer, Douglas B ^a,b   Zuppinger, Christian ^c,d   Miller, Thomas A ^a,b   Eppenberger, Hans M ^c,d   Suter, Thomas M ^c,d,e  

^a BOSTON MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ETH ZURICH   (Switzerland)

^d BERN UNIVERSITY HOSPITAL   (Switzerland)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Anthracyclines; Cardiotoxicity; ErbB2; Myocytes; Neuregulins

Indexed keywords

ANTHRACYCLINE; ANTIBODY; DOXORUBICIN; ENZYME ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE 1; MONOCLONAL ANTIBODY ERBB2; MYOMESIN; NEU DIFFERENTIATION FACTOR; NEUREGULIN 1BETA; PROTEIN KINASE B; RECOMBINANT PROTEIN; TRASTUZUMAB; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HEART FAILURE; HEART MUSCLE CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MUSCLE FIBRIL; NONHUMAN; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIBODIES; ANTIBODIES, MONOCLONAL; CELLS, CULTURED; DOXORUBICIN; DRUG SYNERGISM; FEMALE; HEART VENTRICLES; MICROFILAMENTS; MICROSCOPY, FLUORESCENCE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; NEUREGULIN-1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ERBB-2;

EID: 0037007076     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000013839.41224.1C     Document Type: Article

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