-
2
-
-
33745482769
-
Yeastbased functional genomics and proteomics technologies: The first 15 years and beyond
-
Suter B, Auerbach D, Stagljar I (2006) Yeastbased functional genomics and proteomics technologies: the first 15 years and beyond. Biotechniques 40:625–644
-
(2006)
Biotechniques
, vol.40
, pp. 625-644
-
-
Suter, B.1
Auerbach, D.2
Stagljar, I.3
-
3
-
-
67650070937
-
Functional annotations for the Saccharomyces cerevisiae genome: The knowns and the known unknowns
-
Christie KR, Hong EL, Cherry JM (2009) Functional annotations for the Saccharomyces cerevisiae genome: the knowns and the known unknowns. Trends Microbiol 17:286–294
-
(2009)
Trends Microbiol
, vol.17
, pp. 286-294
-
-
Christie, K.R.1
Hong, E.L.2
Cherry, J.M.3
-
5
-
-
0030747938
-
Human genetic diseases: A cross-talk between man and yeast
-
Foury F (1997) Human genetic diseases: a cross-talk between man and yeast. Gene 195:1–10
-
(1997)
Gene
, vol.195
, pp. 1-10
-
-
Foury, F.1
-
6
-
-
0036275447
-
Getting started with yeast
-
Sherman F (2002) Getting started with yeast. Methods Enzymol 350:3–41
-
(2002)
Methods Enzymol
, vol.350
, pp. 3-41
-
-
Sherman, F.1
-
7
-
-
0033529707
-
Functional characterization of the S. Cerevisiae genome by gene deletion and parallel analysis
-
Winzeler EA, Shoemaker DD, Astromoff A et al (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901–906
-
(1999)
Science
, vol.285
, pp. 901-906
-
-
Winzeler, E.A.1
Shoemaker, D.D.2
Astromoff, A.3
-
8
-
-
34147092780
-
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae
-
Hu Y, Rolfs A, Bhullar B et al (2007) Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res 17: 536–543
-
(2007)
Genome Res
, vol.17
, pp. 536-543
-
-
Hu, Y.1
Rolfs, A.2
Bhullar, B.3
-
9
-
-
40149109321
-
A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae
-
Jones GM, Stalker J, Humphray S et al (2008) A systematic library for comprehensive overexpression screens in Saccharomyces cerevisiae. Nat Methods 5:239–241
-
(2008)
Nat Methods
, vol.5
, pp. 239-241
-
-
Jones, G.M.1
Stalker, J.2
Humphray, S.3
-
10
-
-
0030669030
-
Exploring the metabolic and genetic control of gene expression on a genomic scale
-
DeRisi JL, Iyer VR, Brown PO (1997) Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 278:680–686
-
(1997)
Science
, vol.278
, pp. 680-686
-
-
Derisi, J.L.1
Iyer, V.R.2
Brown, P.O.3
-
11
-
-
52949145931
-
Yeast chemical genomics and drug discovery: An update
-
Hoon S, St Onge RP, Giaever G et al (2008) Yeast chemical genomics and drug discovery: an update. Trends Pharmacol Sci 29:499–504
-
(2008)
Trends Pharmacol Sci
, vol.29
, pp. 499-504
-
-
Hoon, S.1
St Onge, R.P.2
Giaever, G.3
-
12
-
-
33746753342
-
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast
-
Parsons AB, Lopez A, Givoni IE et al (2006) Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell 126:611–625
-
(2006)
Cell
, vol.126
, pp. 611-625
-
-
Parsons, A.B.1
Lopez, A.2
Givoni, I.E.3
-
13
-
-
18044372415
-
Yeast as a model for medical and medicinal research
-
Mager WH, Winderickx J (2005) Yeast as a model for medical and medicinal research. Trends Pharmacol Sci 26:265–273
-
(2005)
Trends Pharmacol Sci
, vol.26
, pp. 265-273
-
-
Mager, W.H.1
Winderickx, J.2
-
14
-
-
77952741735
-
Modelling neurodegeneration in Saccharomyces cerevisiae: Why cook with baker’s yeast?
-
Khurana V, Lindquist S (2010) Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker’s yeast? Nat Rev Neurosci 11:436–449
-
(2010)
Nat Rev Neurosci
, vol.11
, pp. 436-449
-
-
Khurana, V.1
Lindquist, S.2
-
15
-
-
46549089111
-
Protein folding diseases and neurodegeneration: Lessons learned from yeast
-
Winderickx J, Delay C, De Vos A et al (2008) Protein folding diseases and neurodegeneration: lessons learned from yeast. Biochim Biophys Acta 1783:1381–1395
-
(2008)
Biochim Biophys Acta
, vol.1783
, pp. 1381-1395
-
-
Winderickx, J.1
Delay, C.2
De Vos, A.3
-
16
-
-
84880910987
-
The benefits of humanized yeast models to study Parkinson’s disease
-
Franssens V, Bynens T, Van den Brande J et al (2013) The benefits of humanized yeast models to study Parkinson’s disease. Oxid Med Cell Longev 2013:760629
-
(2013)
Oxid Med Cell Longev
, vol.2013
-
-
Franssens, V.1
Bynens, T.2
Van Den Brande, J.3
-
17
-
-
15944378475
-
Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast
-
Zabrocki P, Pellens K, Vanhelmont T et al (2005) Characterization of alpha-synuclein aggregation and synergistic toxicity with protein tau in yeast. FEBS J 272:1386–1400
-
(2005)
FEBS J
, vol.272
, pp. 1386-1400
-
-
Zabrocki, P.1
Pellens, K.2
Vanhelmont, T.3
-
18
-
-
80053372157
-
Aggresome formation and segregation of inclusions influence toxicity of alpha-synuclein and synphilin-1 in yeast
-
Swinnen E, Buttner S, Outeiro TF et al (2011) Aggresome formation and segregation of inclusions influence toxicity of alpha-synuclein and synphilin-1 in yeast. Biochem Soc Trans 39:1476–1481
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1476-1481
-
-
Swinnen, E.1
Buttner, S.2
Outeiro, T.F.3
-
19
-
-
0034652127
-
Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins
-
Krobitsch S, Lindquist S (2000) Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci U S A 97:1589–1594
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1589-1594
-
-
Krobitsch, S.1
Lindquist, S.2
-
20
-
-
0034608868
-
Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils
-
Muchowski PJ, Schaffar G, Sittler A et al (2000) Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proc Natl Acad Sci U S A 97:7841–7846
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7841-7846
-
-
Muchowski, P.J.1
Schaffar, G.2
Sittler, A.3
-
21
-
-
0037053566
-
Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prionlike protein Rnq 1
-
Meriin AB, Zhang X, He X et al (2002) Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prionlike protein Rnq 1. J Cell Biol 157:997–1004
-
(2002)
J Cell Biol
, vol.157
, pp. 997-1004
-
-
Meriin, A.B.1
Zhang, X.2
He, X.3
-
22
-
-
80053349243
-
Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis
-
Bastow EL, Gourlay CW, Tuite MF (2011) Using yeast models to probe the molecular basis of amyotrophic lateral sclerosis. Biochem Soc Trans 39:1482–1487
-
(2011)
Biochem Soc Trans
, vol.39
, pp. 1482-1487
-
-
Bastow, E.L.1
Gourlay, C.W.2
Tuite, M.F.3
-
23
-
-
60449092020
-
ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy
-
Fu L, Sztul E (2009) ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy. Eur J Cell Biol 88:215–226
-
(2009)
Eur J Cell Biol
, vol.88
, pp. 215-226
-
-
Fu, L.1
Sztul, E.2
-
24
-
-
10944223484
-
Tau protein as a differential biomarker of tauopathies
-
Sergeant N, Delacourte A, Buee L (2005) Tau protein as a differential biomarker of tauopathies. Biochim Biophys Acta 1739:179–197
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 179-197
-
-
Sergeant, N.1
Delacourte, A.2
Buee, L.3
-
25
-
-
0035943345
-
A portrait of Alzheimer secretases—new features and familiar faces
-
Esler WP, Wolfe MS (2001) A portrait of Alzheimer secretases—new features and familiar faces. Science 293:1449–1454
-
(2001)
Science
, vol.293
, pp. 1449-1454
-
-
Esler, W.P.1
Wolfe, M.S.2
-
26
-
-
0034049944
-
Proteolytic processing and cell biological functions of the amyloid precursor protein
-
De Strooper B, Annaert W (2000) Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci 113: 1857–1870
-
(2000)
J Cell Sci
, vol.113
, pp. 1857-1870
-
-
De Strooper, B.1
Annaert, W.2
-
27
-
-
77956647381
-
Iron-export ferroxidase activity of betaamyloid precursor protein is inhibited by zinc in Alzheimer’s disease
-
Duce JA, Tsatsanis A, Cater MA et al (2010) Iron-export ferroxidase activity of betaamyloid precursor protein is inhibited by zinc in Alzheimer’s disease. Cell 142:857–867
-
(2010)
Cell
, vol.142
, pp. 857-867
-
-
Duce, J.A.1
Tsatsanis, A.2
Cater, M.A.3
-
28
-
-
2942557122
-
Gamma-secretase: Proteasome of the membrane?
-
Kopan R, Ilagan MX (2004) Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5:499–504
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 499-504
-
-
Kopan, R.1
Ilagan, M.X.2
-
29
-
-
57649174625
-
Intramembrane proteolysis by gammasecretase
-
Steiner H, Fluhrer R, Haass C (2008) Intramembrane proteolysis by gammasecretase. J Biol Chem 283:29627–29631
-
(2008)
J Biol Chem
, vol.283
, pp. 29627-29631
-
-
Steiner, H.1
Fluhrer, R.2
Haass, C.3
-
30
-
-
0042634362
-
Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory
-
Turner PR, O’Connor K, Tate WP et al (2003) Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1–32
-
(2003)
Prog Neurobiol
, vol.70
, pp. 1-32
-
-
Turner, P.R.1
O’Connor, K.2
Tate, W.P.3
-
31
-
-
34447316702
-
Genetics of Alzheimer’s disease: A centennial review
-
Ertekin-Taner N (2007) Genetics of Alzheimer’s disease: a centennial review. Neurol Clin 25:611–667
-
(2007)
Neurol Clin
, vol.25
, pp. 611-667
-
-
Ertekin-Taner, N.1
-
32
-
-
34250819839
-
Intracellular amyloid-beta in Alzheimer’s disease
-
LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer’s disease. Nat Rev Neurosci 8:499–509
-
(2007)
Nat Rev Neurosci
, vol.8
, pp. 499-509
-
-
Laferla, F.M.1
Green, K.N.2
Oddo, S.3
-
33
-
-
33746930858
-
Trafficking of Alzheimer’s disease-related membrane proteins and its participation in disease pathogenesis
-
Suzuki T, Araki Y, Yamamoto T et al (2006) Trafficking of Alzheimer’s disease-related membrane proteins and its participation in disease pathogenesis. J Biochem 139:949–955
-
(2006)
J Biochem
, vol.139
, pp. 949-955
-
-
Suzuki, T.1
Araki, Y.2
Yamamoto, T.3
-
34
-
-
33644849690
-
Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments
-
Vetrivel KS, Thinakaran G (2006) Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments. Neurology 66(2 Suppl 1):S69–S73
-
(2006)
Neurology
, vol.66
, Issue.2-1
, pp. S69-S73
-
-
Vetrivel, K.S.1
Thinakaran, G.2
-
35
-
-
33646461282
-
Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system
-
Almeida CG, Takahashi RH, Gouras GK (2006) Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26:4277–4288
-
(2006)
J Neurosci
, vol.26
, pp. 4277-4288
-
-
Almeida, C.G.1
Takahashi, R.H.2
Gouras, G.K.3
-
36
-
-
34250211094
-
Mitochondrial Abeta: A potential cause of metabolic dysfunction in Alzheimer’s disease
-
Chen X, Yan SD (2006) Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer’s disease. IUBMB Life 58: 686–694
-
(2006)
IUBMB Life
, vol.58
, pp. 686-694
-
-
Chen, X.1
Yan, S.D.2
-
37
-
-
33644845279
-
Amyloid precursor proteinmediated free radicals and oxidative damage: Implications for the development and progression of Alzheimer’s disease
-
Reddy PH (2006) Amyloid precursor proteinmediated free radicals and oxidative damage: implications for the development and progression of Alzheimer’s disease. J Neurochem 96:1–13
-
(2006)
J Neurochem
, vol.96
, pp. 1-13
-
-
Reddy, P.H.1
-
38
-
-
33748934403
-
Alzheimer’s disease and endocytic dysfunction: Clues from the Down syndrome-related proteins, DSCR1 and ITSN 1
-
Keating DJ, Chen C, Pritchard MA (2006) Alzheimer’s disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN 1. Ageing Res Rev 5:388–401
-
(2006)
Ageing Res Rev
, vol.5
, pp. 388-401
-
-
Keating, D.J.1
Chen, C.2
Pritchard, M.A.3
-
39
-
-
11244317067
-
Alzheimer’s amyloid peptides mediate hypoxic up-regulation of L-type Ca 2+ channels
-
Scragg JL, Fearon IM, Boyle JP et al (2005) Alzheimer’s amyloid peptides mediate hypoxic up-regulation of L-type Ca 2+ channels. FASEB J 19:150–152
-
(2005)
FASEB J
, vol.19
, pp. 150-152
-
-
Scragg, J.L.1
Fearon, I.M.2
Boyle, J.P.3
-
40
-
-
33644516276
-
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR 11
-
Andersen OM, Schmidt V, Spoelgen R et al (2006) Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR 11. Biochemistry 45:2618–2628
-
(2006)
Biochemistry
, vol.45
, pp. 2618-2628
-
-
Andersen, O.M.1
Schmidt, V.2
Spoelgen, R.3
-
41
-
-
0028072316
-
Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity
-
Zhang H, Komano H, Fuller RS et al (1994) Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity. J Biol Chem 269:27799–27802
-
(1994)
J Biol Chem
, vol.269
, pp. 27799-27802
-
-
Zhang, H.1
Komano, H.2
Fuller, R.S.3
-
42
-
-
0030700930
-
Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases
-
Zhang W, Espinoza D, Hines V et al (1997) Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases. Biochim Biophys Acta 1359: 110–122
-
(1997)
Biochim Biophys Acta
, vol.1359
, pp. 110-122
-
-
Zhang, W.1
Espinoza, D.2
Hines, V.3
-
43
-
-
0037451709
-
Human beta-secretase activity in yeast detected by a novel cellular growth selection system
-
Luthi U, Schaerer-Brodbeck C, Tanner S et al (2003) Human beta-secretase activity in yeast detected by a novel cellular growth selection system. Biochim Biophys Acta 1620:167–178
-
(2003)
Biochim Biophys Acta
, vol.1620
, pp. 167-178
-
-
Luthi, U.1
Schaerer-Brodbeck, C.2
Tanner, S.3
-
45
-
-
34748873815
-
Proteomic analysis of the amyloid precursor protein fragment C99: Expression in yeast
-
Sparvero LJ, Patz S, Brodsky JL et al (2007) Proteomic analysis of the amyloid precursor protein fragment C99: expression in yeast. Anal Biochem 370:162–170
-
(2007)
Anal Biochem
, vol.370
, pp. 162-170
-
-
Sparvero, L.J.1
Patz, S.2
Brodsky, J.L.3
-
46
-
-
35448944853
-
Alzheimer’s Abeta fused to green fluorescent protein induces growth stress and a heat shock response
-
Caine J, Sankovich S, Antony H et al (2007) Alzheimer’s Abeta fused to green fluorescent protein induces growth stress and a heat shock response. FEMS Yeast Res 7:1230–1236
-
(2007)
FEMS Yeast Res
, vol.7
, pp. 1230-1236
-
-
Caine, J.1
Sankovich, S.2
Antony, H.3
-
47
-
-
82755197062
-
Functional links between Abeta toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast
-
Treusch S, Hamamichi S, Goodman JL et al (2011) Functional links between Abeta toxicity, endocytic trafficking, and Alzheimer’s disease risk factors in yeast. Science 334:1241–1245
-
(2011)
Science
, vol.334
, pp. 1241-1245
-
-
Treusch, S.1
Hamamichi, S.2
Goodman, J.L.3
-
48
-
-
70349558522
-
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease
-
Harold D, Abraham R, Hollingworth P et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. Nat Genet 41: 1088–1093
-
(2009)
Nat Genet
, vol.41
, pp. 1088-1093
-
-
Harold, D.1
Abraham, R.2
Hollingworth, P.3
-
49
-
-
78549264026
-
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease
-
Lambert JC, Heath S, Even G et al (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer’s disease. Nat Genet 41:1094–1099
-
(2009)
Nat Genet
, vol.41
, pp. 1094-1099
-
-
Lambert, J.C.1
Heath, S.2
Even, G.3
-
50
-
-
84872085620
-
A yeast model for amyloid-beta aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity
-
D’Angelo F, Vignaud H, Di Martino J et al (2013) A yeast model for amyloid-beta aggregation exemplifies the role of membrane trafficking and PICALM in cytotoxicity. Dis Model Mech 6:206–216
-
(2013)
Dis Model Mech
, vol.6
, pp. 206-216
-
-
D’Angelo, F.1
Vignaud, H.2
Di Martino, J.3
-
51
-
-
33750010673
-
Modulation of Abeta42 low-n oligomerization using a novel yeast reporter system
-
Bagriantsev S, Liebman S (2006) Modulation of Abeta42 low-n oligomerization using a novel yeast reporter system. BMC Biol 4:32
-
(2006)
BMC Biol
, vol.4
, pp. 32
-
-
Bagriantsev, S.1
Liebman, S.2
-
52
-
-
81455128231
-
Development and validation of a yeast highthroughput screen for inhibitors of Abeta(4) (2) oligomerization
-
Park SK, Pegan SD, Mesecar AD et al (2011) Development and validation of a yeast highthroughput screen for inhibitors of Abeta(4) (2) oligomerization. Dis Model Mech 4: 822–831
-
(2011)
Dis Model Mech
, vol.4
, pp. 822-831
-
-
Park, S.K.1
Pegan, S.D.2
Mesecar, A.D.3
-
53
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buee L, Bussiere T, Buee-Scherrer V et al (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 33:95–130
-
(2000)
Brain Res Brain Res Rev
, vol.33
, pp. 95-130
-
-
Buee, L.1
Bussiere, T.2
Buee-Scherrer, V.3
-
54
-
-
0040141570
-
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
-
Maas T, Eidenmuller J, Brandt R (2000) Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J Biol Chem 275:15733–15740
-
(2000)
J Biol Chem
, vol.275
, pp. 15733-15740
-
-
Maas, T.1
Eidenmuller, J.2
Brandt, R.3
-
55
-
-
0028785525
-
Interaction of tau with the neural plasma membrane mediated by tau’s amino-terminal projection domain
-
Brandt R, Leger J, Lee G (1995) Interaction of tau with the neural plasma membrane mediated by tau’s amino-terminal projection domain. J Cell Biol 131:1327–1340
-
(1995)
J Cell Biol
, vol.131
, pp. 1327-1340
-
-
Brandt, R.1
Leger, J.2
Lee, G.3
-
56
-
-
33947286683
-
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
-
Fulga TA, Elson-Schwab I, Khurana V et al (2007) Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol 9: 139–148
-
(2007)
Nat Cell Biol
, vol.9
, pp. 139-148
-
-
Fulga, T.A.1
Elson-Schwab, I.2
Khurana, V.3
-
57
-
-
79251588043
-
Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn
-
Scales TM, Derkinderen P, Leung KY et al (2011) Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn. Mol Neurodegener 6:12
-
(2011)
Mol Neurodegener
, vol.6
, pp. 12
-
-
Scales, T.M.1
Derkinderen, P.2
Leung, K.Y.3
-
58
-
-
10944228450
-
Tau and src family tyrosine kinases
-
Lee G (2005) Tau and src family tyrosine kinases. Biochim Biophys Acta 1739:323–330
-
(2005)
Biochim Biophys Acta
, vol.1739
, pp. 323-330
-
-
Lee, G.1
-
59
-
-
78751644048
-
Amyloid-beta and tau—a toxic pas de deux in Alzheimer’s disease
-
Ittner LM, Gotz J (2011) Amyloid-beta and tau—a toxic pas de deux in Alzheimer’s disease. Nat Rev Neurosci 12:65–72
-
(2011)
Nat Rev Neurosci
, vol.12
, pp. 65-72
-
-
Ittner, L.M.1
Gotz, J.2
-
60
-
-
43449128899
-
Biochemistry of Tau in Alzheimer’s disease and related neurological disorders
-
Sergeant N, Bretteville A, Hamdane M et al (2008) Biochemistry of Tau in Alzheimer’s disease and related neurological disorders. Expert Rev Proteomics 5:207–224
-
(2008)
Expert Rev Proteomics
, vol.5
, pp. 207-224
-
-
Sergeant, N.1
Bretteville, A.2
Hamdane, M.3
-
64
-
-
23944469853
-
Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast
-
Vandebroek T, Vanhelmont T, Terwel D et al (2005) Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. Biochemistry 44:11466–11475
-
(2005)
Biochemistry
, vol.44
, pp. 11466-11475
-
-
Vandebroek, T.1
Vanhelmont, T.2
Terwel, D.3
-
65
-
-
12644260802
-
The structural basis of monoclonal antibody Alz50’s selectivity for Alzheimer’s disease pathology
-
Carmel G, Mager EM, Binder LI et al (1996) The structural basis of monoclonal antibody Alz50’s selectivity for Alzheimer’s disease pathology. J Biol Chem 271:32789–32795
-
(1996)
J Biol Chem
, vol.271
, pp. 32789-32795
-
-
Carmel, G.1
Mager, E.M.2
Binder, L.I.3
-
66
-
-
0034594482
-
Formation of diffuse and fibrillar tangles in aging and early Alzheimer’s disease
-
Uboga NV, Price JL (2000) Formation of diffuse and fibrillar tangles in aging and early Alzheimer’s disease. Neurobiol Aging 21:1–10
-
(2000)
Neurobiol Aging
, vol.21
, pp. 1-10
-
-
Uboga, N.V.1
Price, J.L.2
-
67
-
-
0034282067
-
Conformational change as one of the earliest alterations of tau in Alzheimer’s disease
-
Weaver CL, Espinoza M, Kress Y et al (2000) Conformational change as one of the earliest alterations of tau in Alzheimer’s disease. Neurobiol Aging 21:719–727
-
(2000)
Neurobiol Aging
, vol.21
, pp. 719-727
-
-
Weaver, C.L.1
Espinoza, M.2
Kress, Y.3
-
68
-
-
0344011447
-
Decreased cyclin-dependent kinase 5 (Cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice
-
Hallows JL, Chen K, DePinho RA et al (2003) Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci 23:10633–10644
-
(2003)
J Neurosci
, vol.23
, pp. 10633-10644
-
-
Hallows, J.L.1
Chen, K.2
Depinho, R.A.3
-
69
-
-
0032786370
-
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
-
Spittaels K, Van den Haute C, Van Dorpe J et al (1999) Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol 155:2153–2165
-
(1999)
Am J Pathol
, vol.155
, pp. 2153-2165
-
-
Spittaels, K.1
Van Den Haute, C.2
Van Dorpe, J.3
-
70
-
-
0033198043
-
CAMP-dependent protein kinase phosphorylations on tau in Alzheimer’s disease
-
Jicha GA, Weaver C, Lane E et al (1999) cAMP-dependent protein kinase phosphorylations on tau in Alzheimer’s disease. J Neurosci 19:7486–7494
-
(1999)
J Neurosci
, vol.19
, pp. 7486-7494
-
-
Jicha, G.A.1
Weaver, C.2
Lane, E.3
-
71
-
-
0032521599
-
Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filamentlike conformation
-
Zheng-Fischhofer Q, Biernat J, Mandelkow EM et al (1998) Sequential phosphorylation of Tau by glycogen synthase kinase-3beta and protein kinase A at Thr212 and Ser214 generates the Alzheimer-specific epitope of antibody AT100 and requires a paired-helical-filamentlike conformation. Eur J Biochem 252: 542–552
-
(1998)
Eur J Biochem
, vol.252
, pp. 542-552
-
-
Zheng-Fischhofer, Q.1
Biernat, J.2
Mandelkow, E.M.3
-
72
-
-
40449087334
-
Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
-
Wen Y, Planel E, Herman M et al (2008) Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. J Neurosci 28:2624–2632
-
(2008)
J Neurosci
, vol.28
, pp. 2624-2632
-
-
Wen, Y.1
Planel, E.2
Herman, M.3
-
73
-
-
33748746596
-
Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk 5
-
Vandebroek T, Terwel D, Vanhelmont T et al (2006) Microtubule binding and clustering of human Tau-4R and Tau-P301L proteins isolated from yeast deficient in orthologues of glycogen synthase kinase-3beta or cdk 5. J Biol Chem 281:25388–25397
-
(2006)
J Biol Chem
, vol.281
, pp. 25388-25397
-
-
Vandebroek, T.1
Terwel, D.2
Vanhelmont, T.3
-
74
-
-
78349245542
-
Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast
-
Vanhelmont T, Vandebroek T, De Vos A et al (2010) Serine-409 phosphorylation and oxidative damage define aggregation of human protein tau in yeast. FEMS Yeast Res 10:992–1005
-
(2010)
FEMS Yeast Res
, vol.10
, pp. 992-1005
-
-
Vanhelmont, T.1
Vandebroek, T.2
De Vos, A.3
-
75
-
-
0037465354
-
Tau polymerization: Role of the amino terminus
-
Gamblin TC, Berry RW, Binder LI (2003) Tau polymerization: role of the amino terminus. Biochemistry 42:2252–2257
-
(2003)
Biochemistry
, vol.42
, pp. 2252-2257
-
-
Gamblin, T.C.1
Berry, R.W.2
Binder, L.I.3
-
76
-
-
77957871737
-
Alzheimer’s proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer’s disease
-
Bobba A, Petragallo VA, Marra E et al (2010) Alzheimer’s proteins, oxidative stress, and mitochondrial dysfunction interplay in a neuronal model of Alzheimer’s disease. Int J Alzheimers Dis 621870, 11 pg
-
(2010)
Int J Alzheimers Dis
, pp. 11
-
-
Bobba, A.1
Petragallo, V.A.2
Marra, E.3
-
77
-
-
75949083202
-
Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates
-
Martinez A, Portero-Otin M, Pamplona R et al (2010) Protein targets of oxidative damage in human neurodegenerative diseases with abnormal protein aggregates. Brain Pathol 20:281–297
-
(2010)
Brain Pathol
, vol.20
, pp. 281-297
-
-
Martinez, A.1
Portero-Otin, M.2
Pamplona, R.3
-
78
-
-
38849150935
-
Mitochondrial oxidative stress causes hyperphosphorylation of tau
-
Melov S, Adlard PA, Morten K et al (2007) Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS One 2:e536
-
(2007)
Plos One
, vol.2
-
-
Melov, S.1
Adlard, P.A.2
Morten, K.3
-
79
-
-
42049116923
-
Alzheimer disease and the role of free radicals in the pathogenesis of the disease
-
Moreira PI, Santos MS, Oliveira CR et al (2008) Alzheimer disease and the role of free radicals in the pathogenesis of the disease. CNS Neurol Disord Drug Targets 7:3–10
-
(2008)
CNS Neurol Disord Drug Targets
, vol.7
, pp. 3-10
-
-
Moreira, P.I.1
Santos, M.S.2
Oliveira, C.R.3
-
80
-
-
0039604509
-
A yeast mutant lacking mitochondrial manganese- superoxide dismutase is hypersensitive to oxygen
-
Van Loon AP, Pesold-Hurt B, Schatz G (1986) A yeast mutant lacking mitochondrial manganese- superoxide dismutase is hypersensitive to oxygen. Proc Natl Acad Sci U S A 83:3820–3824
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 3820-3824
-
-
Van Loon, A.P.1
Pesold-Hurt, B.2
Schatz, G.3
-
81
-
-
0026784158
-
A single-stranded DNA binding protein required for mitochondrial DNA replication in S. Cerevisiae is homologous to E. Coli SSB
-
Van Dyck E, Foury F, Stillman B et al (1992) A single-stranded DNA binding protein required for mitochondrial DNA replication in S. cerevisiae is homologous to E. coli SSB. EMBO J 11:3421–3430
-
(1992)
EMBO J
, vol.11
, pp. 3421-3430
-
-
Van Dyck, E.1
Foury, F.2
Stillman, B.3
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