Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease

BMB Reports

Volumn 48, Issue 7, 2015, Pages 395-400

  Eom, Seon Ae ^a   Kim, Dae Won ^b   Shin, Min Jea ^a   Ahn, Eun Hee ^a   Chung, Seok Young ^a,e   Sohn, Eun Jeong ^a   Jo, Hyo Sang ^a   Jeon, Su Jeong ^c   Kim, Duk Soo ^c   Kwon, H Y Hyeok Yil ^a   Cho, Sung Woo ^d   Han, Kyu Hyung ^a   Park, Jinseu ^a   Eum, Won Sik ^a   Choi, Soo Young ^a  

^a Hallym University   (South Korea)

^b Gangneung Wonju National University   (South Korea)

^c Soonchunhyang University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

^e Shaker High School   (United States)

Author keywords

Dopaminergic neuron; Parkinson's disease; PEP 1 Catalase; Protein therapy; ROS

Indexed keywords

ANIMALIA;

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; HYBRID PROTEIN; NEUROPROTECTIVE AGENT; PEP-1-CATALASE FUSION PROTEIN;

ANIMAL; BRAIN; C57BL MOUSE; CELL DEATH; CELL LINE; CELL SURVIVAL; DISEASE MODEL; DOPAMINERGIC NERVE CELL; DRUG EFFECTS; GENETIC TRANSDUCTION; HUMAN; ISOLATION AND PURIFICATION; MALE; METABOLISM; PARKINSON DISEASE; PATHOLOGY; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ANIMALS; BRAIN; CELL DEATH; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; HUMANS; MALE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TRANSDUCTION, GENETIC;

EID: 84938587131     PISSN: 19766696     EISSN: 1976670X     Source Type: Journal    
DOI: 10.5483/BMBRep.2015.48.7.197     Document Type: Article

References (30)

1. Moore DJ, West AB, Dawson VL and Dawson TM (2005) Molecular pathophysiological of Parkinson's disease. Annu Rev Neurosci 28, 57-87
2. Dawson TM and Dawson VL (2003) Molecular pathways of neurodegeneration in Parkinson'sdisease. Science 302, 819-822
3. Chinta SJ and Andersen JK (2008) Redox imbalance in Parkinson'sdisease. Biochim Biophys Acta 1780, 1362-1367
4. Hunot S and Hirsch EC (2003) Neuroinflammatory processes in Parkinson's disease. Ann Neurol 53, S49-S60
5. Dauer W and Przedborski S (2003) Parkinson's disease:mechanisms and models. Neuron 39, 889-909
6. Henchcliffe C and Beal MF (2008) Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat Clin Pract Neurol 4, 600-609
7. Halliwell B and Gutteridge JM (1990) Role of free radicals and catalytic metal ions in human diseases: an overview. Methods Enzymol 186, 1-85
8. van den Berg A and Dowdy SF (2011) Protein transduction domain delivery of therapeutic macromolecules. Curr Opin Biotechnol 22, 888-893
9. Kubo E, Fatma N, Akagi Y, Beier DR, Singh SP and Singh DP (2008) TAT-mediated PRDX6 protein transduction protects against eye lens epithelial cell death and delays lens opacity. Am J Physiol Cell Physiol 294, C842-C855
10. Kim MJ, Jeong HJ, Kim DW et al (2014) PEP-1-PON1 protect regulates inflammatory response in Raw 264.7 macrophages and ameliorates inflammation in a TPA-induced animal model. PLoS One 9, e86034
11. Ahn EH, Kim DW, Shin MJ et al (2013) Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress through increasing its transduction efficiency. BMB Rep 46, 561-566
12. An JJ, Eum WS, Kwon HS et al (2013) Protective effects of skin permeable epidermal and fibroblast growth factor against ultraviolet-induced skin damage and human skin wrinkles. J Cosmet Dermatol 12, 287-295
13. Ahn EH, Kim DW, Shin MJ et al (2013) PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model. Free Radic Biol Med 55, 36-45
14. Kwon SW, Sohn EJ, Kim DW et al (2011) Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model. Biochem Biophys Res Commun 411, 354-359
15. Shin MJ, Kim DW, Lee YP et al (2014) Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury. Free Radic Biol Med 67, 195-210
16. Kim SY, Sohn EJ, Kim DW et al (2011) Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice. J Invest Dermatol 131, 1477-1485
17. Kim DW, Lee SH, Ku SK et al (2013) Transduced PEP-1-FK506BP ameliorates corneal injury in Botulinum toxin A-induced dry eye mouse model. BMB Rep 46, 124-129
18. Kim DW, Jeong HJ, Kang HW et al (2009) Transduced human PEP-1-catalase fusion protein attenuates ischemic neuronal damage. Free Radic Biol Med 47, 941-952
19. Mates M (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153, 83-104
20. Wadia JS and Dowdy SF (2002) Protein transduction technology. Curr Opin Biotechnol 13, 52-56
21. Kaul S, Kanthasamy A, Kitazawa M, Anantharam V and Kanthasamy AG (2003) Caspase-3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells: relevance to oxidative stress n dopaminergic degeneration. Eur J Neurosci 18, 1387-1401
22. Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y and Chu CT (2007) Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium- induced cell death. Am J Pathol 170, 75-86
23. Choi WS, Canzoniero LM, Sensi SL et al (1999) Characterization of MPP+-induced cell death in a dopaminergic neuronal cell line : role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins. Exp Neurol 159, 274-282
24. Hu S, Han R, Mak S and Han Y (2011) Protection against 1-methyl-4-phenyl pyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells. J. Ethnopharmacol 135, 34-42
25. Choi WS, Yoon SY, Oh TH, Choi EJ, O'Malley KL and Oh YJ (1999) Two distinct mechanisms are involved in 6-hydroxydopamine- and MPP+-induced dopaminergic neuronal cell death: role of caspases, ROS, and JNK. J Neurosci Res 57, 86-94
26. Martin HL, Mounsey RB, Mustafa S, Sathe K and Teisma P (2012) Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease. Exp Neurol 235, 528-538
27. Fuenzalida K, Quintanilla R, Ramos P et al (2007) Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces apoptosis. J Biol chem 282, 37006-37015
28. Hashimoto R, Yu J, Koizumi H, Ouchi Y and Okabe T (2012) Ginsenoside Rb1 prevents MPP+-induced apoptosis in PC12 cells by stimulating estrogen receptors with consequent activation of ERK1/2, Akt and inhibition of SAPK/ JNK, p38 MAPK. Evid Based Complement Alternat Med Med 2012, 693717
29. Burke RE (2007) Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways:two approaches with therapeutic potential in the treatment of neurodegenerative disease. Pharmacol Ther 114, 261-277
30. Shukla AK, Pragya P, Chaouhan HS et al (2014) Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegenration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease. PLoS One 9, e98886