Heat shock protein-70 (Hsp-70) suppresses paraquat-induced neurodegeneration by inhibiting JNK and caspase-3 activation in Drosophila model of Parkinson's disease

PLoS ONE

Volumn 9, Issue 6, 2014, Pages

  Shukla, Arvind Kumar ^a,d   Pragya, Prakash ^a,d   Chaouhan, Hitesh Singh ^a,c   Tiwari, Anand Krishna ^b   Patel, Devendra Kumar ^a   Abdin, Malik Zainul ^d   Chowdhuri, Debapratim Kar ^a  

^a CSIR INDIAN INSTITUTE OF TOXICOLOGY RESEARCH   (India)

^b Indian Institute of Advanced Research   (India)

^c ACADEMY OF SCIENTIFIC AND INNOVATIVE RESEARCH ACSIR   (India)

^d HAMDARD UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; HEAT SHOCK PROTEIN 70; PARAQUAT; STRESS ACTIVATED PROTEIN KINASE; DROSOPHILA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME INHIBITION; HOMEOSTASIS; LOCOMOTION; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL RATE; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; MOTOR ACTIVITY; PARKINSONIAN DISORDERS; PHYSIOLOGY; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASE 3; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; HSP70 HEAT-SHOCK PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MOTOR ACTIVITY; OXIDATIVE STRESS; PARAQUAT; PARKINSONIAN DISORDERS; UP-REGULATION;

EID: 84902331740     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0098886     Document Type: Article

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