Circumventing the blood-brain barrier: Local delivery of cyclosporin A stimulates stem cells in stroke-injured rat brain

Journal of Controlled Release

Volumn 215, Issue , 2015, Pages 1-11

  Tuladhar, Anup ^a,b   Morshead, Cindi M ^a,b   Shoichet, Molly S ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Blood brain barrier; Cyclosporin A; Drug delivery; Hydrogel; Neural stem progenitor cell; Stroke

Indexed keywords

BLOOD; CELL PROLIFERATION; CELLS; CYTOLOGY; DRUG DELIVERY; DRUG DOSAGE; HYDROGELS; RATS; TISSUE;

BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; CYCLOSPORIN A; NEURAL STEM/PROGENITOR CELLS; POLY LACTIC-CO-GLYCOLIC ACID; PROGENITOR CELL; PROLIFERATING CELLS; STROKE;

STEM CELLS;

CYCLOSPORIN A; DRUG CARRIER; HYALURONIC ACID; METHYLCELLULOSE; POLYGLACTIN; CYCLOSPORIN; HYDROGEL; IMMUNOSUPPRESSIVE AGENT; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN SIZE; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG EXPOSURE; DRUG PENETRATION; DRUG RELEASE; DRUG TISSUE LEVEL; HYDROGEL; HYDROPHOBICITY; IMMUNOSUPPRESSIVE TREATMENT; LATERAL BRAIN VENTRICLE; MALE; MICROENCAPSULATION; MOTOR CORTEX; NONHUMAN; OSMOTIC MINIPUMP; PARTICLE SIZE; PRIORITY JOURNAL; RAT; STEM CELL; SUSTAINED DRUG RELEASE; ANIMAL; BRAIN INFARCTION; CELL COUNT; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG FORMULATION; LONG EVANS RAT; METABOLISM; PATHOLOGY; STROKE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN INFARCTION; CELL COUNT; CYCLOSPORINE; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; HYALURONIC ACID; HYDROGELS; IMMUNOSUPPRESSIVE AGENTS; LACTIC ACID; LATERAL VENTRICLES; MALE; METHYLCELLULOSE; POLYGLYCOLIC ACID; RATS; RATS, LONG-EVANS; STEM CELLS; STROKE;

EID: 84938563630     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.07.023     Document Type: Article

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